ABSTRACT
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Subject(s)
Humans , Female , Aged , Lupus Erythematosus, Discoid/diagnosis , Anti-Bacterial Agents/administration & dosage , Hydroxychloroquine/administration & dosage , Lupus Erythematosus, Cutaneous/complications , Lupus Erythematosus, Discoid/therapy , Scalp/drug effects , Scalp/pathology , Biopsy , Photosensitivity Disorders/complications , Diagnosis, DifferentialSubject(s)
Collagen Diseases/diagnosis , Hodgkin Disease/complications , Skin Diseases/diagnosis , Adjustment Disorders/etiology , Adult , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/therapeutic use , Collagen Diseases/etiology , Collagen Diseases/pathology , Female , Hodgkin Disease/drug therapy , Hodgkin Disease/pathology , Humans , Neoplasm Staging , Pruritus/diagnosis , Pruritus/etiology , Skin Diseases/pathology , Treatment OutcomeABSTRACT
El síndrome de POEMS es una rara alteración multisistémica caracterizada por polineuropatía (P), organomegalia (O), endocrinopatía (E), discrasia sanguínea con paraproteína (M) y lesiones cutáneas (S, skin) cuya etiopatogenia no se conoce por completo. Este síndrome paraneoplásico puede asociarse a lesiones óseas que típicamente son osteoscleróticas o líticas con un reborde esclerótico y que suelen ser negativas en la gammagrafía ósea. Se presenta el caso de un varón de 37 años con diversas manifestaciones del síndrome POEMS que en las pruebas de imagen mostraba lesiones óseas características de mieloma osteoesclerótico que se confirmaron mediante biopsia ósea (AU)
POEMS syndrome is a rare multisystemic disorder characterized by polyneuropathy (P), organomegaly (O), endocrinopathy (E), blood dyscrasia with M-protein band (M), and skin changes (S). The pathogenesis of POEMS syndrome is not completely understood. This paraneoplastic syndrome may be associated to bone lesions that are characteristically sclerotic or lytic with sclerotic halo and negative at bone scintigraphy. We report a case of a 37-year-old man with several manifestations of POEMS syndrome who presented bone lesions characteristic of osteosclerotic myeloma confirmed by bone biopsy (AU)
Subject(s)
Humans , Male , Adult , POEMS Syndrome/diagnosis , POEMS Syndrome/surgery , Biopsy/methods , Osteosclerosis/complications , Osteosclerosis , Multiple Myeloma/complications , Multiple Myeloma/diagnosis , POEMS Syndrome/physiopathology , POEMS Syndrome , Multiple MyelomaABSTRACT
POEMS syndrome is a rare multisystemic disorder characterized by polyneuropathy (P), organomegaly (O), endocrinopathy (E), blood dyscrasia with M-protein band (M), and skin changes (S). The pathogenesis of POEMS syndrome is not completely understood. This paraneoplastic syndrome may be associated to bone lesions that are characteristically sclerotic or lytic with sclerotic halo and negative at bone scintigraphy. We report a case of a 37-year-old man with several manifestations of POEMS syndrome who presented bone lesions characteristic of osteosclerotic myeloma confirmed by bone biopsy.
Subject(s)
POEMS Syndrome , Adult , Humans , Male , POEMS Syndrome/diagnosisABSTRACT
Gastrointestinal stromal tumors (GIST) appear in the abdominal cavity in less than 5% of patients. We present two cases of extraintestinal GIST attended in our service and treated with imatinib mesylate. We review the current treatment of these neoplasms with targeted therapies.
Subject(s)
Gastrointestinal Stromal Tumors/pathology , Pelvis/pathology , Adult , Aged , Female , Gastrointestinal Stromal Tumors/diagnostic imaging , Gastrointestinal Stromal Tumors/surgery , Humans , Laparotomy , Pelvis/diagnostic imaging , Pelvis/surgery , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Los tumores del estroma gastrointestinal se presentan fuera del tubo digestivo en menos del 5% de los casos. Presentamos 2 casos de tumores del estroma gastrointestinal extraintestinales atendidos en nuestro servicio y tratados con imatinib mesilato. Revisamos la situación actual del tratamiento de dichas neoplasias con terapias dirigidas
Gastrointestinal stromal tumors (GIST) appear in the abdominal cavity in less than 5% of patients. We present two cases of extraintestinal GIST attended in our service and treated with imatinib mesylate. We review the current treatment of these neoplasms with targeted therapies