ABSTRACT
Introduction: Hospital pharmacists are increasingly playing a critical role in the care of patients with multiple sclerosis (MS). However, little is known about their preferences and perspectives towards different attributes of disease-modifying therapies (DMTs). The objective of this research was to assess pharmacists´ preferences for DMT efficacy attributes. Methods: A multicenter, non-interventional, cross-sectional, web-based study was conducted. Preventing relapses, delaying disease progression, controlling radiological activity, and preserving health-related quality of life (HRQoL) and cognition were the attributes selected based on a literature review and a focus group with six hospital pharmacists. Conjoint analysis was used to determine preferences in eight hypothetical treatment scenarios, combining different levels of each attribute and ranking them from most to least preferred. Results: Sixty-five hospital pharmacists completed the study (mean age: 43.5 ± 7.8 years, 63.1% female, mean years of professional experience: 16.1 ± 7.4 years). Participants placed the greatest preference on delaying disease progression (35.7%) and preserving HRQoL (21.6%) and cognition (21.6%). Importance was consistent in all groups of pharmacists stratified according to demographic characteristics, experience, research background, and volume of patients seen per year. Conclusions: Understanding which treatment characteristics are meaningful to hospital pharmacists may help to enhance their synergistic role in the multidisciplinary management of patients with MS.
ABSTRACT
PURPOSE: Adherence to disease-modifying treatments is essential in order to maximize the beneficial effects of treatment for multiple sclerosis (MS). There are numerous treatments that have been approved. Treatment selection is essential in patient adherence. In addition, patient preference plays an increasingly significant role in treatment decision-making. This study aims to evaluate the degree of adherence, along with other variables that may influence this adherence, in Spain. METHODS: A cross-sectional study was conducted with 157 MS patients with disease-modifying treatments. Adherence was assessed using the Morisky Green scale, and other related factors were measured using a questionnaire that addressed demographics, disease characteristics, global perception of pathology, impact of medication on patient's life, and treatment decision-making. RESULTS: The adherence rate was 71% and was associated with the following variables: older age, more treatments received, time to diagnosis 5-10 years, absence of exacerbations, better cognitive status, being married/in a union, clear information about the disease, and higher treatment satisfaction. The main cause for non-compliance was forgetfulness (27%). CONCLUSION: The adherence rate is acceptable. It is widely known that treatment satisfaction is related to adherence. In our study, patients' level of satisfaction was higher with oral treatments. However, oral administration showed a greater lack of adherence. The main cause of lack of adherence was forgetfulness. In relation to other variables, cognitive status and family support showed a correlation with treatment adherence.
ABSTRACT
Los 13 y 14 años del ciclo vital humano son muy sensibles al entorno, por lo que los procesos migratorios y los cambios de condiciones de vida asociados pueden incidir en mayor medida. El objetivo del estudio es caracterizar la situación somática y nutricional de la población adolescente inmigrante de Madrid con la objetividad de la valoración bioantropométrica. Se han evaluado 519 adolescentes escolarizados no nacidos en España. Los muestreos se efectuaron en los centros escolares públicos de la Comunidad de Madrid y se realizaron los siguientes grupos: Muestra control española (38,9%), América Latina (50,9%), Norte de África (4,5%), Asia (3,8%) y Europa del Este (1,9%). La situación ponderal es de Normopeso para el total de la muestra, salvo en los varones de Europa del Este (Sobrepeso). El patrón alimentario reflejó una frecuencia diaria de ingestas de 3,73±0,91, siendo la comida más representada la cena. La calidad de la dieta medida por KidMed mostró que el 10,2% seguía una dieta de baja calidad, el 58,6% presenta una dieta mejorable y el 31,2% óptima. Las mayores puntuaciones se encontraron en el colectivo Magrebí y las más bajas en el Asiático. En todos los grupos se encontró una tendencia al aumento de la ingesta de fruta y verdura en España.
The 13 and 14 years of human life cycle are very sensitive to environment, so that migration and changes in living conditions related may influence further. The aim of this study is to characterize the nutritional and somatic status of the immigrant adolescent population of Madrid with the objectivity of bioanthropometric assessment. 519 adolescent students not born in Spain were evaluated. The sample was taken in the public schools of the Community of Madrid and conducted the following groups: Spanish control sample (38.9%), Latin America (50.9%), Magreb (4.5%), Asia (3.8%) and Eastern Europe (1.9%). The situation is Normal weight for the total sample, except in boys of Eastern Europe (Overweight). The pattern reflected a daily dietary intake of 3.73 ± 0.91, being the dinner the most represented food. The diet quality as measured by KidMed showed that 10.2% followed a low quality diet, 58.6% have a better diet and 31.2% optimal. Higher scores were found in the Magreb group and lowest in Asia. In all groups showed a trend towards increased consumption of fruit and vegetables in Spain.
