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1.
Rev Soc Bras Med Trop ; 36(2): 217-21, 2003.
Article in Portuguese | MEDLINE | ID: mdl-12806457

ABSTRACT

UNLABELLED: Evaluation of the renal involvement of visceral leishmaniasis (kala-azar) aiming at verifying clinical and laboratorial repercussions of the renal implication on VL. Laboratory analysis was performed of blood and urine samples collected immediately after confirming diagnosis through the finding of Leishmania in bone marrow. Two (18.1%) patient presented complications associated with kala-azar. Five patients (45.4%) presented macroscopic hematuria and one case (N 9) clinical manifestations compatible with an acute nephritis syndrome. Laboratorial data of urine exam showed: proteinuria in 10 (90.9%) patients, hematuria in 7 (63.6%) and leukocyturia in 6 (54.5%) cases. Nine (81.8%) patients presented high levels of microalbuminuria, characterizing glomerular lesion. The presence of proximal tubulopathy, measured through retinol binding protein observed in 5 (45.4%) cases. CONCLUSION: renal involvement was manifested in most subjects, contributing to the severity of the disease.


Subject(s)
Kidney Diseases/parasitology , Leishmaniasis, Visceral/complications , Adolescent , Adult , Albuminuria/parasitology , Animals , Bone Marrow/parasitology , Child , Child, Preschool , Female , Glomerular Filtration Rate , Hematuria/parasitology , Humans , Infant , Infant, Newborn , Leishmania donovani/isolation & purification , Male , Prospective Studies
2.
Rev. Soc. Bras. Med. Trop ; 36(2): 217-221, mar.-abr. 2003. tab
Article in Portuguese | LILACS | ID: lil-340899

ABSTRACT

Envolvimento da funçäo renal em pacientes com leishmaniose visceral (calazar). Apresenta-se estudo prospectivo de 11 pacientes com LV, com o intuito de verificar as repercussöes clínico-laboratoriais da funçäo renal na doença. Realizou-se análises laboratoriais das amostras de sangue e urina, colhidas logo após confirmaçäo diagnóstica, através do encontro de leishmanias no aspirado de médula óssea. Dois (18 por cento) pacientes apresentaram complicaçöes associadas a LV. Cinco (45,4 por cento) apresentaram hematúria macroscópica e em um caso (No.9) manifestaçöes clínicas compatíveis com síndrome nefrítica aguda. Os resultados dos exames de urina mostraram: proteinúria em 10 (90,9 por cento) pacientes, hematúria 7 (63,6 por cento) e leucocitúria em 6 (54,5 por cento) casos. Nove (81,8 por cento) pacientes apresentaram níveis elevados de microalbuminúria caracterizando lesäo glomerular. A presença de tubulopatia proximal medida através da proteína ligadora de retinol, foi observada em 5 (45,4 por cento) casos. Concluiu-se que o envolvimento renal se fez presente na maioria dos pacientes, contribuindo para a gravidade da doença


Subject(s)
Adolescent , Adult , Animals , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Kidney Diseases/parasitology , Leishmaniasis, Visceral/complications , Albuminuria/parasitology , Bone Marrow/parasitology , Glomerular Filtration Rate , Hematuria/parasitology , Leishmania donovani/isolation & purification , Prospective Studies
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