ABSTRACT
Monkeypox is a zoonotic viral disease. Monkeypox was first reported in humans about 54 years ago. Prior to the global outbreak, monkeypox was endemic to the rainforests of central and western African countries. In the last three years, increasing numbers of human monkeypox have been reported from various countries. Responding to the severity, monkeypox was declared a Public Health Emergency of International Concern by the World Health Organization. In the absence of approved drugs or clinical studies, repurposed drugs and therapeutic medical countermeasures effective against other orthopoxviruses have been utilized to treat severe human monkeypox cases. Currently, clinical trials are underway exploring the potential therapeutic effectiveness of tecovirimate in human monkeypox cases. Monoclonal antibodies, IFN-ß, resveratrol, and 15 triple-targeting FDA-approved drugs represent potential new drug targets for human monkeypox, necessitating further research.
ABSTRACT
Background: India is home to 69.2 million diabetics. For opportunistic screening of type 2 diabetes mellitus (DM), random capillary blood sugar (RBS) testing is used. Another method is Indian Diabetes Risk Score (IDRS), which is a simple and cost effective method for opportunistic screening of type 2 DM patients. The aim is to evaluate the screening test parameters of RBS testing and IDRS for opportunistic screening of undiagnosed type 2 DM patients. Materials and Methods: A cross-sectional study was done during February 2017 to August 2017 at a district hospital of Western Gujarat. A sample size of 317 patients was calculated using Buderer's formula. Systematic random sampling was used and every third patient was selected from the general Outpatient Department(OPD) attendees of 30 years or more. MS Excel and Epi Info v7.2 was used for statistical analysis. Screening parameters and accuracy of IDRS and RBS were calculated taking result of the oral glucose tolerance test as clinical reference. Results: The mean age of study participants was 50.9 (SD 12.17) years with 44.2% males and 55.8% females. Sensitivity and specificity of RBS was 72.4% and 69.1%. Sensitivity and specificity of IDRS was 93.1% and 29.0%. On simultaneous (parallel) screening by IDRS and RBS, sensitivity was 98.3% and specificity was 23.2%. In sequential screening, where IDRS was used followed by RBS, sensitivity was 67.2% and specificity was 74.9%. Conclusions: This study has found that sequential screening using a simple diabetes risk score like IDRS followed by RBS is having higher accuracy and reduced cost of opportunistic screening of type 2 diabetes. Adopting sequential screening using IDRS as first step of screening followed by RBS in those found as high risk by IDRS is recommended.
ABSTRACT
INTRODUCTION: During the COVID-19 pandemic, most educational institutions have opted for online education rather than traditional modes of education to protect their employees and students. Online education has been gaining momentum in almost all countries around the world. This coincides with the recently introduced competency-based medical education in India which has embraced online education. This poses a new challenge for the institutions involved, the instructors or teachers, and the students since they must adapt quickly to the new mode of learning. Online education requires teachers to improve their competency in three major areas; pedagogy, technology, and content knowledge. Some of the challenges include; lack of technological skill, poor time management and lack of infrastructure. As technology rapidly advances, health care education systems must also advance in tandem. To implement the new competency-based system and online education, the institutions and the individuals must realize the importance of online education, identify the barriers and quickly work on solutions for success. METHODS: This review was conducted based on various research papers on the topic of online medical education, the challenges faced by faculty members, and the opinion of students on this dilemma. Search terms included online medical education, COVID19, competency-based medical education. CONCLUSION: This review identified various challenges posed by online education on the current medical curriculum, faced by both faculty members and students, especially under the light of the Competency-Based Undergraduate Curriculum for Indian Graduates. Different solutions were proposed to overcome these challenges.
ABSTRACT
This article was migrated. The article was marked as recommended. Introduction: Students enter new environment in medical colleges at around 17 years of age directly from school which can be challenging. Therefore, in Graduate Medical Regulations 2018 of India, attempt has been made to orient medical learners to MBBS program and provide them with requisite knowledge, communication, technical and language skills through a month-long foundation program. The purpose of this study is to share learning and to document feedback and best practices that would enhance the value and structure of the program in coming years. Methodology: Descriptive evaluation of the foundation program implemented at a medical college located in western India as per the guidelines of the Curriculum Implementation Support Program (CISP). This program was implemented by all medical colleges under the ambit of Medical Council of India from August 2019. Teaching-Learning Methods:Interactive sessions and assessment mainly based on reflective writing or by verbal/written feedback. To help in program evaluation and refinementa pretested semi-structured questionnaire administered to the students and faculty to gather their perceptions about various aspects of the course on a Likert scale of 1-5; 5-Strongly agree, 4-Agree, 3-Uncertain, 2-Disagree, 1-Strongly Disagree and three open-ended questions at the end of the course . Data was entered into Microsoft Excel 2007 and descriptive statistics utilized for interpretation of perceptions, themes and direct quotation used in the analysis. Take Home Message: The enthusiasm, hard work and integrated effort by the faculty members who participated in the program were extremely important for the success of this course. It is learnt that the Foundation program highlights benefits, is a valuable vehicle for increasing students' overall confidence. There are challenges involved in operationalization viz; it requires more time and effort from faculty, at least in the initial phases of program development.
ABSTRACT
BACKGROUND: The first case of 2009 pandemic influenza A (H1N1) virus infection in India was reported in May, 2009 and in Saurashtra region in August, 2009. We describe the clinico-epidemiological characteristics of patients who were hospitalized with 2009 influenza A (H1N1) infection in Saurashtra region. MATERIALS AND METHODS: From September, 2009 to February, 2010, we observed 274 persons infected with 2009 influenza A (H1N1) virus who were admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features of the disease were closely monitored. RESULTS: Of 274 patients, median age was 29.5 years, and 51.5% were males. Only 1.1% patients had recent travel history to infected region. Median time of five days was observed from onset of illness to influenza A (H1N1) diagnosis, while median time of six days reported for hospital stay. All admitted patients received oseltamivir drug, but only 16.1% received it within two days of onset of illness. One fourth of admitted patients were expired. The most common symptoms were cough (96.7%), fever (92%), sore throat and shortness of breathing, and coexisting conditions including diabetes mellitus (9.9%), hypertension (8.8%), chronic pulmonary diseases (5.5%) and pregnancy (5.5%) (P<0.05). Pneumonia was reported in 93% patients with chest radiography. CONCLUSION: We have demonstrated that infection-related illness affects both children and adults with survival of 74% patients. The median time from onset of illness to virus detection with use of real-time RT-PCR is five days. Pregnancy is found as a significant (P<0.05) risk factor for severe disease.
