1.
Blood Cancer J
; 7(3): e542, 2017 03 10.
Article
in English
| MEDLINE
| ID: mdl-28282031
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Granulocyte Colony-Stimulating Factor/administration & dosage , Hematopoietic Stem Cell Mobilization , Heterocyclic Compounds/administration & dosage , Leukemia, Myeloid, Acute/therapy , Stem Cell Transplantation , Adolescent , Adult , Aged , Autografts , Benzylamines , Cyclams , Cytarabine/administration & dosage , Etoposide/administration & dosage , Female , Humans , Male , Middle Aged , Mitoxantrone/administration & dosage
2.
Bioconjug Chem
; 8(1): 49-56, 1997.
Article
in English
| MEDLINE
| ID: mdl-9026035
ABSTRACT
meso-Tris(4-pyridyl)[[(omega-hydroxyhexamethylene)carbamoyl]phenyl ] porphyrin was converted to its H-phosphonate derivative and conjugated using solid phase synthesis with the 5'-hydroxyl group of deoxyribonucleotides d(TCTTCCCA) and d(T)12. These conjugates were transformed into their (N-methylpyridiniumyl)porphyrin analogs in the reaction with methyl iodide. A 532 nm laser beam was utilized to photoactivate both types of the conjugates in the presence of the target 22-mer and 16-mer oligonucleotides. Photoactivation of porphyrin-oligonucleotide conjugates resulted in site-specific DNA modification characterized by a main reaction site size of approximately 5 bases.