Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Cell Host Microbe ; 23(4): 485-497.e5, 2018 04 11.
Article in English | MEDLINE | ID: mdl-29649442

ABSTRACT

Plants employ cell-surface pattern recognition receptors (PRRs) to detect pathogens. Although phytohormones produced during PRR signaling play an essential role in innate immunity, a direct link between PRR activation and hormone regulation is unknown. EFR is a PRR that recognizes bacterial EF-Tu and activates immune signaling. Here we report that EFR regulates the phytohormone jasmonic acid (JA) through direct phosphorylation of a receptor-like cytoplasmic kinase, BIK1. The BIK1 structure revealed that the EFR-phosphorylated sites reside on a uniquely extended loop away from the BIK1 kinase core domain. Phosphomimetic mutations of these sites resulted in increased phytohormones and enhanced resistance to bacterial infections. In addition to its documented plasma membrane localization, BIK1 also localizes to the nucleus and interacts directly with WRKY transcription factors involved in the JA and salicylic acid (SA) regulation. These findings demonstrate the mechanistic basis of signal transduction from PRR to phytohormones, mediated through a PRR-BIK1-WRKY axis.


Subject(s)
Arabidopsis Proteins/metabolism , Gene Expression Regulation, Plant , Plant Growth Regulators/biosynthesis , Plant Immunity , Protein Serine-Threonine Kinases/metabolism , Receptors, Pattern Recognition/metabolism , Transcription Factors/metabolism , Arabidopsis/physiology , Bacterial Infections/immunology , Cyclopentanes/metabolism , Immunity, Innate , Oxylipins/metabolism , Phosphorylation , Plant Diseases/immunology , Protein Binding , Protein Processing, Post-Translational , Signal Transduction
SELECTION OF CITATIONS
SEARCH DETAIL
...