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15.
Actas Dermosifiliogr ; 108(7): e49-e52, 2017 Sep.
Article in English, Spanish | MEDLINE | ID: mdl-28407871

ABSTRACT

Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype-phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the disease may be present in the same patient or relatives. Histopathology reveals dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae. We report 3 new cases of this type of Darier disease triggered by injuries. Response to retinoid therapy was good.


Subject(s)
Darier Disease/etiology , Hand Injuries/complications , Acitretin/therapeutic use , Adult , Darier Disease/drug therapy , Darier Disease/genetics , Darier Disease/pathology , Dermatologic Agents/therapeutic use , Female , Humans , Isotretinoin/therapeutic use , Male , Middle Aged , Nails, Malformed/etiology , Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics , Seasons , Tretinoin/therapeutic use
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