ABSTRACT
The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (-)-3,4,5-trimethoxyphenyl beta-D-glucopyranoside (3), (+)-syringaresinol beta-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.
Subject(s)
Anisoles , Antineoplastic Agents, Phytogenic/analysis , Plants, Medicinal/analysis , Animals , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Chemical Phenomena , Chemistry , Humans , KB Cells/drug effects , Leukemia P388/pathology , Plant Extracts/analysis , Plant Extracts/pharmacology , Propylene Glycols/isolation & purification , Propylene Glycols/pharmacology , Tumor Cells, Cultured/drug effectsABSTRACT
PIP: Literature on the phytochemical study of plant estrogens is reviewed. The coumestans reportedly have a greater degree of estrogenic activity than the isoflavones. Diethylstilbestrol is the prototype of the synthetic silbene derivatives. Of the natural stilbenes, only rhaponticin possesses estrogenic activity, though this is not firmly established. 6, 4'-dihydroxyflavone has also been reported to have estrogenic activity. Coumestrol and genistein have been shown to compete with 17beta-estradiol for binding sites in the uterus of young rabbits. Vinblastine, demecolene, and podophyllotoxin posses known cyto toxic, antifertility properties. Naturally occurring steroid estrogens, estrogenic isoflavins, coumestans, plants with reported estrogenic activity, and cytotoxic agents with antifertility properties are listed along with their plant sources.^ieng