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BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.

Acosta-Medina, Aldo A; Kemps, Paul G; Zondag, Timo C E; Abeykoon, Jithma P; Forma-Borst, Jelske; Steenwijk, Eline C; Feijen, Elizabeth A M; Teepen, Jop C; Bennani, N Nora; Schram, Susan M; Shah, Mithun V; Davidge-Pitts, Caroline; Koster, Matthew J; Ryu, Jay H; Vassallo, Robert; Tobin, W Oliver; Young, Jason R; Dasari, Surendra; Rech, Karen; Ravindran, Aishwarya; Cleven, Arjen H G; Verdijk, Robert M; van Noesel, Carel J M; Balgobind, Brian V; Bouma, Gerrit Joan; Saeed, Peerooz; Bramer, Jos A M; de Groen, Ruben A L; Vermaat, Joost S P; van de Sande, Michiel A J; Smit, Egbert F; Langerak, Anton W; van Wezel, Tom; Tonino, Sanne H; van den Bos, Cor; van Laar, Jan A M; Go, Ronald S; Goyal, Gaurav; van Halteren, Astrid G S.

Blood ; 142(18): 1570-1575, 2023 11 02.

Article in English | MEDLINE | ID: mdl-37595284

ABSTRACT

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

Subject(s)

Histiocytosis, Langerhans-Cell , Neoplasms, Second Primary , Humans , Adult , Neoplasms, Second Primary/epidemiology , Neoplasms, Second Primary/genetics , Proto-Oncogene Proteins B-raf/genetics , Retrospective Studies , Incidence , Histiocytosis, Langerhans-Cell/epidemiology , Histiocytosis, Langerhans-Cell/genetics , Histiocytosis, Langerhans-Cell/pathology , Mutation

ABSTRACT

Subject(s)

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