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1.
Am J Alzheimers Dis Other Demen ; 27(1): 33-40, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22296910

ABSTRACT

This article describes a pilot project involving training, case consultations, and administrative coaching over a period of 1 year aimed at introducing palliative care in 2 nursing homes among 31 residents with advanced dementia. Resident outcomes that examined numerous clinical measures were assessed at 3 points in time. Changes in the knowledge and attitudes of 80 staff members and 33 family members who participated in the multimodal intervention were also assessed at 3 points in time. Limited improvements were demonstrated on measures for residents, staff members, and family members at the first nursing home (site 1) and significant improvements were demonstrated at the other nursing home (site 2). Top leadership turned over 3 times at site 1 which limited the integration of palliative care, whereas leadership of site 2 remained stable. Implications for implementing a program of palliative care in nursing homes are discussed.


Subject(s)
Caregivers , Dementia/nursing , Nursing Homes , Nursing Staff , Palliative Care , Adult , Aged , Aged, 80 and over , Alzheimer Disease/nursing , Attitude of Health Personnel , Family , Humans , Middle Aged , Pilot Projects
3.
AACN Clin Issues ; 16(3): 291-301, 2005.
Article in English | MEDLINE | ID: mdl-16082232

ABSTRACT

The endogenous opioid system is one of the most studied innate pain-relieving systems. This system consists of widely scattered neurons that produce three opioids: beta-endorphin, the met- and leu-enkephalins, and the dynorphins. These opioids act as neurotransmitters and neuromodulators at three major classes of receptors, termed mu, delta, and kappa, and produce analgesia. Like their endogenous counterparts, the opioid drugs, or opiates, act at these same receptors to produce both analgesia and undesirable side effects. This article examines some of the recent findings about the opioid system, including interactions with other neurotransmitters, the location and existence of receptor subtypes, and how this information drives the search for better analgesics. We also consider how an understanding of the opioid system affects clinical responses to opiate administration and what the future may hold for improved pain relief. The goal of this article is to assist clinicians to develop pharmacological interventions that better meet their patient's analgesic needs.


Subject(s)
Analgesics, Opioid/therapeutic use , Opioid Peptides/drug effects , Opioid Peptides/physiology , Pain , Analgesics, Opioid/pharmacology , Drug Administration Schedule , Drug Tolerance/physiology , Humans , Neurons, Afferent/drug effects , Neurons, Afferent/physiology , Opioid Peptides/classification , Pain/drug therapy , Pain/physiopathology , Peripheral Nerves/drug effects , Peripheral Nerves/physiopathology , Receptors, Opioid/classification , Receptors, Opioid/drug effects , Receptors, Opioid/physiology , Spinal Cord/drug effects , Spinal Cord/physiopathology , Substance Withdrawal Syndrome/etiology , Substance Withdrawal Syndrome/prevention & control
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