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1.
J Phys Chem Lett ; 14(20): 4796-4802, 2023 May 25.
Article in English | MEDLINE | ID: mdl-37191100

ABSTRACT

The surface charge of an open water surface is crucial for solvation phenomena and interfacial processes in aqueous systems. However, the magnitude of the charge is controversial, and the physical mechanism of charging remains incompletely understood. Here we identify a previously overlooked physical mechanism determining the surface charge of water. Using accurate charge measurements of water microdrops, we demonstrate that the water surface charge originates from the electrostatic effects in the contact line vicinity of three phases, one of which is water. Our experiments, theory, and simulations provide evidence that a junction of two aqueous interfaces (e.g., liquid-solid and liquid-air) develops a pH-dependent contact potential difference Δϕ due to the longitudinal charge redistribution between two contacting interfaces. This universal static charging mechanism may have implications for the origin of electrical potentials in biological, nanofluidic, and electrochemical systems and helps to predict and control the surface charge of water in various experimental environments.

2.
Annu Int Conf IEEE Eng Med Biol Soc ; 2022: 1565-1568, 2022 07.
Article in English | MEDLINE | ID: mdl-36086199

ABSTRACT

In this paper, a broadband microwave device for cell poration is presented, that enables the analysis of the relation between frequency, electrical field strengths and temperature for a successful cell poration. Electromagnetic-thermal coupled simulations in the frequency range from 1 GHz to 10 GHz show that the device reaches electrical field strengths of 100 V/cm and temperatures lower then 40°C. Electroporation experiments with adherent C2C12 mouse myoblast cells show successful uptake of an anti-histone γ -H2A.X nanobody at a frequency of 10 GHz. This MWP device allows the fast electro-poration of adherent cells. After 15 min, the cells show uptake of γ -H2A.X-specific nanobody while most of them survived.


Subject(s)
Electroporation , Microwaves , Animals , Electricity , Mice , Temperature
3.
J Am Coll Health ; 70(7): 1959-1963, 2022 10.
Article in English | MEDLINE | ID: mdl-33258751

ABSTRACT

ObjectivesAs food insecurity among college students in the United States continues to rise, large quantities of food are wasted on college campuses. This paper presents a simple, low-cost approach to address both issues, using an electronic learning management system to connect college students with good quality excess food. Participants: Students at a small East Coast urban university. Methods: Using the MAP-IT framework, a university-wide food rescue system was developed to alert students to obtain food. Results: During the first twelve months of implementation, 451 students enrolled to receive announcements. 78% of students reported satisfaction with the food obtained. Conclusions: This program was successful in providing students with access to desirable food that would otherwise have been wasted.


Subject(s)
Refuse Disposal , Students , Cross-Sectional Studies , Educational Technology , Food , Food Insecurity , Food Supply , Humans , United States , Universities
4.
Aliment Pharmacol Ther ; 54(6): 742-754, 2021 09.
Article in English | MEDLINE | ID: mdl-34323292

ABSTRACT

BACKGROUND: Poor dietary intake is associated with the development of malnutrition, micronutrient deficiencies, anaemia and osteoporosis in individuals with inflammatory bowel disease. While trials are underway to manipulate the diet of people with IBD, there has been no comprehensive systematic review of the dietary intake of adults with IBD. AIMS: To conduct a systematic evaluation and meta-analysis of the dietary intake of adults with IBD, including macronutrients, micronutrients and food group data. METHODS: CINAHL, Embase, Medline and Scopus were searched from 1 January 2000 to 25 September 2020 for cohort, case-control or cross-sectional studies that reported usual dietary intake in adults. Data were pooled and reported as weighted mean intake for: all adults with IBD; Crohn's disease; ulcerative colitis; active disease; remission; males; females. A random-effects meta-analysis model compared intake with healthy individuals. RESULTS: Forty studies were identified and 19 were included in the meta-analysis. All subgroups of adults with IBD consumed inadequate energy (mean intake in adults with IBD 1980 ± 130 kcal), fibre (14 ± 4 g), folate (246 ± 33 mg) and calcium (529 ± 114 mg) per day. Intake of breads and cereals, legumes, fruit, vegetables and dairy were inadequate. Compared to healthy individuals, adults with IBD consume significantly less dietary fibre (SMD -0.59; 95% CI: -0.73, -0.46). CONCLUSIONS: This review provides improved clarity about the dietary intake of adults with IBD. Future attention is required to improve diet quality and increase understanding of factors influencing dietary intake in IBD.


Subject(s)
Colitis, Ulcerative , Crohn Disease , Inflammatory Bowel Diseases , Adult , Cross-Sectional Studies , Eating , Female , Humans , Male
5.
J Fam Violence ; 35(5): 405-416, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32655209

ABSTRACT

PURPOSE: This study examined the moderating role of household chaos in indirect pathways involving domestic violence (DV), parenting practices (punitive discipline and responsive), and preschool children's internalizing and externalizing symptoms. We hypothesized that high levels of household chaos would amplify links between domestic violence and parenting difficulties, and that parenting difficulties would in turn predict child behavior problems. METHOD: Participants in this multimethod (survey, semi-structured interview, child protection records) study included 274 preschool children (M age = 50.86 months) and their primary caregivers who were assessed in the home at two time-points spaced 6 months apart. Child welfare documentation of moderate-severe maltreatment within the last 6 months was present for 52% of children, 44% were in households characterized by DV, and most families qualified for public assistance. Hypotheses were tested using path analysis with manifest variables within a structural equation modeling framework. RESULTS: All models provided excellent fit to the data. DV was associated with punitive discipline practices only when household chaos was high. Punitive discipline practices in turn predicted greater child externalizing symptoms 6 months later. Follow-up analyses revealed that the moderating role of chaos was specific to DV, rather than general to other forms of adversity (child maltreatment, lifetime contextual stressors, traumatic events). This interaction between DV and chaos was salient even when controlling for exposure to other adversities and demographic covariates. CONCLUSIONS: Results point to multiple potential targets of intervention that may ultimately buffer children from the risk posed by experiencing DV in the home.

6.
Article in German | MEDLINE | ID: mdl-31802152

ABSTRACT

BACKGROUND AND AIM: Reasons for lower use of medical services by children and adolescents with migration background have not yet been investigated. The aim is therefore to identify factors that are related to the utilization of outpatient medical care and subjective patient satisfaction as well as explain differences according to migration background. METHODS: On the basis of the "German Health Interview and Examination Survey for Children and Adolescents" (KiGGS, baseline study: 2003-2006), in which 17,640 children and adolescents participated, prevalences with 95% confidence intervals as well as multivariate binary logistic regression analyzes on the relationship between migration background, country of origin, the use of outpatient medical care services in the last 12 months, and satisfaction with the last medical treatment were calculated. RESULTS: Children up to age 13 with two-sided migration background had lower utilization of specialist doctors compared to those without migration background (OR = 0.64 [0.56-0.74]). However, among the 14- to 17-year-olds, the utilization did not differ significantly (OR = 0.79 [0.60-1.03]). The lower use of outpatient medical care is associated with a shorter length of stay and limited German language skills. In addition, parents from Poland and the former Soviet Union are less likely to be very satisfied with the last outpatient treatment of their 0­ to 13-year-old child, even after adjustments for German language skills and length of stay. CONCLUSION: To make it easier for children with migration background to access specialist services, it is important to reduce language barriers in outpatient medical care and to promote processes of intercultural opening.


Subject(s)
Outpatients , Personal Satisfaction , Transients and Migrants/statistics & numerical data , Adolescent , Child , Child, Preschool , Cross-Sectional Studies , Germany , Health Surveys , Humans , Infant , Infant, Newborn , USSR
7.
Article in German | MEDLINE | ID: mdl-31529190

ABSTRACT

BACKGROUND: Even though 36.5% of children and adolescents living in Germany have a migration background (MB), data on the health of this population is scarce. With population-based data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017), reliable statements can be given. METHODS: Data from KiGGS Wave 2 is used in order to report on general health status, mental health, and the distribution of allergic diseases among children and adolescents aged 3-17 years (n = 13,568). To determine overweight, standardized measurements of body weight and height (n = 3463) were used. In addition to the MB (none/one-sided/two-sided), the socioeconomic status (SES) is considered. In multivariate analyses among children and adolescents with MB, SES and the parents' duration of stay in Germany were included. RESULTS: Participants with a two-sided MB show lower prevalence of neurodermatitis (3.5% vs. 6.9%) and ADHS (2.0% vs. 5.1%) than those without a migration background and higher prevalence of fair to poor general health status (6.1% vs. 3.9%). Children and adolescents with a two-sided migration background are more often affected by overweight than those without migration background (22.1% vs. 12.2%). After considering SES, the chances of a diagnosed neurodermatitis and ADHS remain higher and the chances for overweight are lower in children and adolescents with a migration background than among those without migration background. If only children with MB are considered, SES and partially the parents' duration of stay in Germany are associated with health outcomes. CONCLUSION: Differences in the general health status of children and adolescents with and without MB vary depending on the observed indicators. The heterogeneity of children and adolescents with MB, e.g. regarding SES and parents' duration of stay, should be considered when planning and implementing measures of health promotion.


Subject(s)
Health Status , Social Class , Adolescent , Adolescent Health , Child , Child Health/statistics & numerical data , Child, Preschool , Cross-Sectional Studies , Germany , Health Surveys , Humans , Prevalence , Socioeconomic Factors
8.
Nutr Clin Pract ; 34(5): 657-665, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31074906

ABSTRACT

Malnutrition has been documented in approximately one-third of patients in developed countries on hospital admission and is associated with negative clinical outcomes. The need to identify and intervene in at-risk patients is critical to minimize these negative outcomes. A consensus approach for diagnosing and documenting malnutrition in hospitalized adult and pediatric patients was published jointly by the Academy of Nutrition and Dietetics (Academy) and the American Society for Parenteral and Enteral Nutrition (ASPEN) in 2012 and 2014, respectively. The purpose of this paper is to review the available literature on the usability, feasibility, validity, and reliability of both the adult and pediatric consensus malnutrition diagnostic approaches, as well as to evaluate their use in studying clinical outcomes. In adults, abstracts and published studies have shown the diagnostic tool is a usable, feasible, and reliable method for the identification of severe and non-severe or moderate malnutrition. In pediatrics, only 1 published study to date used the pediatric malnutrition indicators, indicating the need to demonstrate that the tool is feasible, valid, and reliable. Both the adult and pediatric tools have shown significant correlation with negative clinical outcomes in malnourished patients, including increased mortality, increased hospital length of stay (adults), increased complications (pediatrics), and increased hospital readmissions. Further large-scale studies are needed to evaluate the feasibility, usability, validity, and reliability of both the adult and pediatric malnutrition diagnostic approaches.


Subject(s)
Dietetics/standards , Malnutrition/diagnosis , Nutrition Assessment , Nutritional Support/standards , Outcome Assessment, Health Care/standards , Academies and Institutes , Adult , Child , Consensus , Feasibility Studies , Female , Humans , Male , Reproducibility of Results , Societies, Medical
9.
J Adolesc Young Adult Oncol ; 8(3): 243-253, 2019 06.
Article in English | MEDLINE | ID: mdl-30785806

ABSTRACT

Background: Timeliness is one of the fundamental yet understudied quality metrics of cancer care. Little is known about cancer treatment delay among adolescent and young adult (AYA) cancer patients. This study assessed cancer treatment delay, with a specific focus on facility transfer and diagnosis/treatment interval. Methods: Based on MultiCare Health System's (MHS's) institutional cancer registry data of AYA patients diagnosed during 2006-2015, this study analyzed patient demographics, insurance, clinical characteristics, and time of diagnosis and treatment initiation. Chi-squared tests, cumulative hazard estimates, and Cox proportional regression were used for univariable analysis. Multivariate regression models were used to test the association between care transfer and days of interval or prolonged delay, controlling for baseline parameters. Results: Of 840 analytic AYA cases identified, 457 (54.5%) were both diagnosed and treated within MHS. A total of 45.5% were either diagnosed or treated elsewhere. Mean and median intervals for treatment initiation were 27.03 (95% CI = 21.94-33.14) and 8.00 days (95% CI = 5.00-11.00), respectively, with significant differences between patients with and without facility transfer. Transfer was significantly correlated with longer length of diagnosis-to-treatment interval. Treatment delay, ≥1 week, was associated with transfer, female sex, older age, no surgery involvement, and more treatment modalities. Treatment delay, ≥4 weeks, was associated with transfer, female sex, no insurance, and no surgery involvement. Conclusion: In a community care setting, the diagnosis-to-treatment interval is significantly longer for transferred AYA cancer patients than for patients without a transfer. Future studies are warranted to explore the prognostic implications and the reasons for delays within specific cancer types.


Subject(s)
Neoplasms/therapy , Adolescent , Adult , Child , Female , Humans , Male , Neoplasms/pathology , Prognosis , Retrospective Studies , Time Factors , Young Adult
10.
BMC Health Serv Res ; 18(1): 755, 2018 Oct 03.
Article in English | MEDLINE | ID: mdl-30285753

ABSTRACT

BACKGROUND: It is aspired in the German healthcare system that general practitioners (GPs) act as initial contact for patients and guide through at all steps of medical treatment. This study aims at identifying factors associated with the odds of having no GP within the general population and especially among people with migration background. METHODS: This cross-sectional analysis was based on the "German Health Interview and Examination Survey for Adults" (DEGS1) conducted by the Robert Koch Institute. Descriptive analyses as well as multiple logistic regression models were performed to analyse the impact of a migration background, age, gender, residential area, socioeconomic status (SES) and other factors on having no GP among 7755 participants. RESULTS: 9.5% of the total study population and 14.8% of people with a migration background had no GP, especially men, adults living in big cities and without chronic diseases. The odds of not having a GP were higher for people with a two-sided migration background (aOR: 1.90, 95% CI: 1.42-2.55). Among the population with a migration background, particularly young adults, men, people living in big cities and having a private health insurance showed higher odds to have no GP. CONCLUSIONS: It is necessary to investigate the causes of the differing utilization of healthcare of people with a migration background and, if necessary, to take measures for an equal access to healthcare for all population groups. Further research needs to be done to evaluate how to get young people into contact with a GP.


Subject(s)
Chronic Disease/therapy , Emigration and Immigration/statistics & numerical data , General Practitioners/supply & distribution , Patient Acceptance of Health Care/statistics & numerical data , Adolescent , Adult , Chronic Disease/epidemiology , Epidemiologic Methods , Female , Germany/epidemiology , Humans , Male , Social Class , Young Adult
11.
J Health Monit ; 3(1): 126-142, 2018 Mar.
Article in English | MEDLINE | ID: mdl-35586177

ABSTRACT

In the context of health monitoring at the Robert Koch Institute, the baseline study of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) surveyed a sample of children and adolescents with a migration background according to their share within the general population through extensive measures. Owing to less comprehensive efforts, this was not accomplished in the follow-up KiGGS Wave 1 study. For KiGGS Wave 2, the objective therefore was, through targeted measures, to increase the willingness of children and adolescents with a migration background to participate in the survey. This article describes the approaches to include children and adolescents with a migration background, the operationalisation of migration-specific variables and the effectiveness of field visits prior to the actual survey as a tool to increase the willingness of these groups to participate in the survey. Furthermore, data on participation and the sample of children and adolescents with a migration background in the cross-sectional KiGGS Wave 2 study is presented. Overall, 2,994 children with a migration background aged 0 to 17 years took part in KiGGS Wave 2. In the weighted sample this corresponds to 11.8% (n=1,436) with a one-sided and 17.0% (n=1,558) with a two-sided migration background. In sum, the share of children and adolescents surveyed with a migration background (28.8%) is almost that of their share in Microcensus 2013 (31.2%). Compared to children and adolescents without a migration background, barely any differences exist in age and gender distribution, while differences are seen regarding social status; children with a two-sided migration background are significantly more often found in the low social status group. In the sample, the most often represented countries of origin were the countries of Central and South Europe, of the former Soviet Union and Turkey. Regarding the length of time parents had lived in Germany, around 40.1% of migrant families have been living in the country for over 20 years, whereas nearly one in five families has been in Germany for less than five years. A total of 12.2% of children and adolescents with a migration background migrated themselves. By implementing a comprehensive set of measures, the degree after weighting to which children and adolescents with a migration background were included in KiGGS Wave 2 is nearly commensurate to their share in the overall population.

12.
Surg Obes Relat Dis ; 13(5): 727-741, 2017 May.
Article in English | MEDLINE | ID: mdl-28392254

ABSTRACT

BACKGROUND: Optimizing postoperative patient outcomes and nutritional status begins preoperatively. Patients should be educated before and after weight loss surgery (WLS) on the expected nutrient deficiencies associated with alterations in physiology. Although surgery can exacerbate preexisting nutrient deficiencies, preoperative screening for vitamin deficiencies has not been the norm in the majority of WLS practices. Screening is important because it is common for patients who present for WLS to have at least 1 vitamin or mineral deficiency preoperatively. OBJECTIVES: The focus of this paper is to update the 2008 American Society for Metabolic and Bariatric Surgery Nutrition in Bariatric Surgery Guidelines with key micronutrient research in laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy, biliopancreatic diversion, and biliopancreatic diversion/duodenal switch. METHODS: Four questions regarding recommendations for preoperative and postoperative screening of nutrient deficiencies, preventative supplementation, and repletion of nutrient deficiencies in pre-WLS patients have been applied to specific micronutrients (vitamins B1 and B12; folate; iron; vitamins A, E, and K; calcium; vitamin D; copper; and zinc). RESULTS: Out of the 554 articles identified as meeting preliminary search criteria, 402 were reviewed in detail. There are 92 recommendations in this update, 79 new recommendations and an additional 13 that have not changed since 2008. Each recommendation has a corresponding graded level of evidence, from grade A through D. CONCLUSIONS: Data continue to suggest that the prevalence of micronutrient deficiencies is increasing, while monitoring of patients at follow-up is decreasing. This document should be viewed as a guideline for a reasonable approach to patient nutritional care based on the most recent research, scientific evidence, resources, and information available. It is the responsibility of the registered dietitian nutritionist and WLS program to determine individual variations as they relate to patient nutritional care.


Subject(s)
Avitaminosis/prevention & control , Bariatric Surgery/methods , Micronutrients/deficiency , Nutritional Support/methods , Vitamins/administration & dosage , Humans , Micronutrients/administration & dosage , Nutritional Status
13.
J Pediatr Endocrinol Metab ; 30(3): 327-332, 2017 Mar 01.
Article in English | MEDLINE | ID: mdl-28236628

ABSTRACT

BACKGROUND: Knowledge concerning energy metabolism in Turner syndrome (TS) is lacking. We compared the resting energy expenditure per fat-free mass (REE/FFM) in TS with other girls with short stature treated with growth hormone (GH) and age-related controls. METHODS: We measured prospectively REE by spirometry under fasting conditions in the morning in 85 short prepubertal girls at the start of GH treatment. Diagnoses were TS (n=20), GH deficiency (GHD) (n=38) and small for gestational age (SGA) short stature (n=27). Additionally, 20 age-related controls were studied. Mean ages were 8.3 (TS), 7.1 (GHD), 6.9 (SGA) and 8.5 years (controls). Mean heights were -2.90 (TS), -3.32 (GHD), -3.69 (SGA) and -0.03 standard deviation scores (SDS) (controls). FFM was measured by bioelectrical impedance analysis (BIA). RESULTS: At the start of GH girls with TS showed insignificantly higher REE per FFM (REE/FFM) (mean±SD; 65±9 kcal/kg×day) than did the other female patients (62±9 kcal/kg×day) (p>0.23). The healthy controls had significantly lower REE/FFM (35±4 kcal/kg×day) (p<0.001). Follow-up examination of the patients after 6 or 12 months revealed decreasing REE/FFM in TS (62±9 kcal/kg×day) resulting in comparable REE/FFM in all three patient groups. CONCLUSIONS: At baseline short girls with TS had insignificantly higher REE/FFM than short children with SGA or GHD, but in follow-up this difference was not detectable any more. Future studies are necessary to understand this observation.


Subject(s)
Basal Metabolism/physiology , Body Height/physiology , Dwarfism/physiopathology , Energy Metabolism/physiology , Infant, Small for Gestational Age/metabolism , Turner Syndrome/physiopathology , Basal Metabolism/drug effects , Body Composition/drug effects , Body Height/drug effects , Case-Control Studies , Child , Child, Preschool , Dwarfism/complications , Dwarfism/drug therapy , Energy Metabolism/drug effects , Female , Follow-Up Studies , Human Growth Hormone/analogs & derivatives , Human Growth Hormone/therapeutic use , Humans , Infant , Prognosis , Prospective Studies , Turner Syndrome/complications , Turner Syndrome/drug therapy
14.
Curr Dev Nutr ; 1(5): e000620, 2017 May.
Article in English | MEDLINE | ID: mdl-29955702

ABSTRACT

Background: Reduced rank regression (RRR) is an approach to identify dietary patterns associated with biochemical markers and risk of type 2 diabetes (T2D). Objective: We aimed to derive dietary patterns associated with adiponectin, leptin, C-reactive protein (CRP), and triglycerides (TGs) and to examine the prospective associations of these patterns with T2D risk in 5 ethnic/racial groups with differences in T2D rates. Methods: The Multiethnic Cohort (MEC) included 215,831 African-American, Japanese-American, Latino, Native Hawaiian, and white adults living in Hawaii and California who completed a validated quantitative food-frequency questionnaire in 1993-1996. T2D status was based on self-report with confirmation by administrative data. Serum CRP and TGs and plasma adiponectin and leptin were measured ∼10 y after baseline in a subset (n = 10,008) of participants. RRR was applied to dietary data and biomarker information of 10,008 MEC participants in the combined population and in each ethnic/racial group. RRR-derived dietary patterns, simplified by removal of foods that were not found to be important, were subsequently evaluated for association with T2D risk in 155,316 cohort members (8687 incident T2D cases diagnosed by 2010) by using Cox proportional hazards regression. Results: Combining ethnic/racial groups, we identified a dietary pattern low in processed and red meat, sugar-sweetened beverages, diet soft drinks, and white rice and high in whole grains, fruit, yellow-orange vegetables, green vegetables, and low-fat dairy that was inversely associated with CRP, TGs, and leptin and positively related to adiponectin. Comparing extreme tertiles, the dietary pattern predicted a 16-28% significantly lower T2D risk in the combined study population and also separately in African Americans, Japanese Americans, Latinos, Native Hawaiians, and whites. Ethnicity-specific derived patterns varied only modestly from the overall pattern and resulted in comparable associations with T2D. Conclusion: This identified dietary pattern may lower T2D risk through its impact on adipokines, by lowering chronic inflammation and dyslipidemia across 5 ethnic/racial groups.

15.
J Health Monit ; 2(1): 22-42, 2017 Mar.
Article in English | MEDLINE | ID: mdl-37151305

ABSTRACT

The wars and devastation of recent years have driven many people to flee their homes. Great numbers of asylum seekers and refugees have sought protection in Europe. In 2015 and 2016 alone, over one million people applied for asylum in Germany. This has posed a great challenge for Germany's healthcare provision facilities. The health of asylum seekers and refugees and the provision of their healthcare is therefore an important issue in terms of public health. The first part of this article describes the extent and legal framework of immigration to Germany during the past two years. The second part then discusses the issue of health and medical care for asylum seekers and refugees. Until now, no representative data on the health of this population exists. Studies so far have all relied on a small number of cases and been limited to particular regions and are therefore hard to compare. Moreover, there are no sufficiently standardised medical examinations during initial reception across all German federal states. Relevant findings suggest an urgent need to take action in the fields of mental health, chronic diseases and the provision of care to children of asylum seekers. A review of the data available proves the need for a national and systematic collection of valid data as a basis for adequate preventive and medical care. Different initiatives currently aim to improve the data collection basis in Germany. Over time, these new initiatives will significantly improve the data available on the health situation of asylum seekers and refugees in Germany. Once politics and broader society take these findings into account, this should contribute to an objective debate and evidence-based decisions.

16.
J Health Monit ; 2(Suppl 3): 2-27, 2017 Sep.
Article in English | MEDLINE | ID: mdl-37377941

ABSTRACT

The fieldwork of the second follow-up to the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) was completed in August 2017. KiGGS is part of the Robert Koch Institute's Federal Health Monitoring. The study consists of the KiGGS cross-sectional component (a nationally representative, periodic cross-sectional survey of children and adolescents aged between 0 and 17) and the KiGGS cohort (the follow-up into adulthood of participants who took part in the KiGGS baseline study). KiGGS collects data on health status, health-related behaviour, psychosocial risk and protective factors, health care and the living conditions of children and adolescents in Germany. The first interview and examination survey (the KiGGS baseline study; undertaken between 2003 and 2006; n=17,641; age range: 0-17) was carried out in a total of 167 sample points in Germany. Physical examinations, laboratory analyses of blood and urine samples and various physical tests were conducted with the participants and, in addition, all parents and participants aged 11 or above were interviewed. The first follow-up was conducted via telephone-based interviews (KiGGS Wave 1 2009-2012; n=11,992; age range: 6-24) and an additional sample was included (n=4,455; age range: 0-6). KiGGS Wave 2 (2014-2017) was conducted as an interview and examination survey and consisted of a new, nationwide, representative cross-sectional sample of 0- to 17-year-old children and adolescents in Germany, and the second KiGGS cohort follow-up. The completion of the cross-sectional component of KiGGS Wave 2 means that the health of children and adolescents in Germany can now be assessed using representative data gained from three study waves. Trends can therefore be analysed over a period stretching to over ten years now. As the data collected from participants of the KiGGS cohort can be individually linked across the various surveys, in-depth analyses can be conducted for a period ranging from childhood to young adulthood and developmental processes associated with physical and mental health and the associated risk and protective factors can be explored. As such, KiGGS Wave 2 expands the resources available to health reporting, as well as policy planning and research, with regard to assessing the health of children and adolescents in Germany.

18.
Mil Med ; 181(5 Suppl): 191-8, 2016 05.
Article in English | MEDLINE | ID: mdl-27168572

ABSTRACT

PURPOSE: To examine the difference in bone health and body composition via blood biomarkers, bone mineral density, anthropometrics and dietary intake following deployment to Afghanistan among soldiers randomized to receive telehealth coaching promoting nutrition and exercise. METHODS: This was a prospective, longitudinal, cluster-randomized, controlled trial with repeated measures in 234 soldiers. Measures included heel bone scan for bone mineral density, blood biomarkers for bone formation, resorption, and turnover, body composition via Futrex, resting metabolic rate via MedGem, physical activity using the Baecke Habitual Physical Activity Questionnaire, and dietary intake obtained from the Block Food Frequency Questionnaire. RESULTS: There were significant increases in body fat (p = 0.00035), osteocalcin (0.0152), and sports index (p = 0.0152) for the telehealth group. No other statistically significant differences were observed between groups. Vitamin D intake among soldiers was ≤ 35% of the suggested Dietary Reference Intakes for age. CONCLUSIONS: A 9-month deployment to Afghanistan increased body fat, bone turnover, and physical activity among soldiers randomized to receive telehealth strategies to build bone with nutrition and exercise.


Subject(s)
Biomarkers/analysis , Exercise/psychology , Mentoring/standards , Military Personnel/psychology , Telemedicine/methods , Afghan Campaign 2001- , Alkaline Phosphatase/analysis , Alkaline Phosphatase/blood , Biomarkers/blood , Body Composition , Bone Density , Calcium/analysis , Calcium/blood , Diet/standards , Female , Humans , Insulin-Like Growth Factor I/analysis , Longitudinal Studies , Male , Mentoring/methods , Osteocalcin/analysis , Osteocalcin/blood , Prospective Studies , Risk Factors , Risk Management/methods , Self Report , Surveys and Questionnaires , Vitamin D/analogs & derivatives , Vitamin D/analysis , Vitamin D/blood , Warfare , Young Adult
20.
Nutrients ; 7(7): 5497-514, 2015 Jul 07.
Article in English | MEDLINE | ID: mdl-26198248

ABSTRACT

Reduced rank regression (RRR) is an innovative technique to establish dietary patterns related to biochemical risk factors for type 2 diabetes, but has not been applied in sub-Saharan Africa. In a hospital-based case-control study for type 2 diabetes in Kumasi (diabetes cases, 538; controls, 668) dietary intake was assessed by a specific food frequency questionnaire. After random split of our study population, we derived a dietary pattern in the training set using RRR with adiponectin, HDL-cholesterol and triglycerides as responses and 35 food items as predictors. This pattern score was applied to the validation set, and its association with type 2 diabetes was examined by logistic regression. The dietary pattern was characterized by a high consumption of plantain, cassava, and garden egg, and a low intake of rice, juice, vegetable oil, eggs, chocolate drink, sweets, and red meat; the score correlated positively with serum triglycerides and negatively with adiponectin. The multivariate-adjusted odds ratio of type 2 diabetes for the highest quintile compared to the lowest was 4.43 (95% confidence interval: 1.87-10.50, p for trend < 0.001). The identified dietary pattern increases the odds of type 2 diabetes in urban Ghanaians, which is mainly attributed to increased serum triglycerides.


Subject(s)
Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/etiology , Diet , Feeding Behavior , Urban Population , Adult , Biomarkers , Case-Control Studies , Female , Ghana/epidemiology , Humans , Logistic Models , Male , Middle Aged , Odds Ratio , Sensitivity and Specificity , Socioeconomic Factors , Surveys and Questionnaires , Urban Health
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