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Signalling and pharmacological properties of the P2Y receptor.

Harden, T K; Sesma, J I; Fricks, I P; Lazarowski, E R.

Acta Physiol (Oxf) ; 199(2): 149-60, 2010 Jun.

Article in English | MEDLINE | ID: mdl-20345417

ABSTRACT

The P2Y(14) receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators.

Subject(s)

Protein Isoforms/metabolism , Receptors, Purinergic P2/metabolism , Signal Transduction/physiology , Animals , Epithelial Cells/metabolism , Gastrointestinal Tract/metabolism , HL-60 Cells , Humans , Immune System/physiology , Mitogen-Activated Protein Kinases/metabolism , Protein Isoforms/genetics , Receptors, Purinergic P2/genetics , Uridine Diphosphate/metabolism , Uridine Diphosphate Sugars/metabolism

ABSTRACT

Subject(s)

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