ABSTRACT
UNLABELLED: In this retrospective study, the efficiency of the postoperative follow-up regimen was evaluated in patients, radically operated for cancer of the colon or cancer of the rectum. The follow-up regimen consisted of clinical examination, including sigmoidoscopy every six months, supplemented by an X-ray of the colon every year. Two-hundred and eighty-nine patients were included in the study. Twenty-three local recurrences and 19 new malignant tumors were diagnosed 20 and 13 months (mean) after the primary operation, respectively. About one third of the local recurrences and half of the new malignant tumors were diagnosed at the planned follow-ups. Among these patients, a significantly higher success rate as regards radical operation was observed at the second operation. IN CONCLUSION: more frequent follow-ups during the first two years after the primary operation are recommended in order to improve early diagnosis.
Subject(s)
Colonic Neoplasms/surgery , Neoplasm Recurrence, Local/diagnosis , Rectal Neoplasms/surgery , Aged , Colonic Neoplasms/diagnosis , Female , Follow-Up Studies , Humans , Male , Rectal Neoplasms/diagnosis , Retrospective StudiesABSTRACT
Ten patients for elective cholecystectomy were studied pre-, per-and postoperatively. All had neurolept anesthesia. Plasma concentrations of beta-TG, TXB2 and 5-HT and intraplatelet 5-HT were measured. Aggregation to ADP was recorded. Serum cortisol concentration was used as index of the stress response, showing peroperative increase and postoperative decrease. Closely related to this we observed a significant increase in P--beta-TG and P-TXB2 with postoperative normalization in 6 patients without complications. P--5-HT had a peak peroperatively and remained elevated postoperatively. A negative correlation between P--5-HT and decreasing intraplatelet 5-HT postoperatively was observed. High postoperative levels of P--5-HT seem to be related to low arterial PO2 and pulmonary dysfunction. In 3 patients with complications a second increase in P--beta-TG, P-TXB2 and partly in P--5-HT was found. Platelets were temporarily refractory to ADP immediately following surgery and showed increased aggregability postoperatively. We conclude that platelets are activated in surgical stress.