ABSTRACT
Five polyketides, paralactonic acids A-E (1-5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1-5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.
Subject(s)
Anti-Bacterial Agents/chemistry , Ascomycota/chemistry , Chondrus/microbiology , Polyketides/chemistry , Anti-Bacterial Agents/isolation & purification , Japan , Molecular Structure , Polyketides/isolation & purification , Seaweed/microbiologyABSTRACT
The scandium sulfonate-based coordination polymer Sc2(BPDS)3, which is easily prepared by mixing scandium triisopropoxides and biphenyl-4,4'-disulfonic acid (BPDSA), is an air-stable and storable solid that effectively catalyzes the Friedel-Crafts reaction of indoles with aromatic aldehydes under heterogeneous conditions to afford various aryl(diindolyl)methanes. The catalyst can be reused without significant loss of activity after separation from the reaction mixture by simple centrifugation followed by drying.
Subject(s)
Aldehydes/chemistry , Arylsulfonates , Indoles/chemistry , Polymers , Scandium , Catalysis , Centrifugation , Drug Stability , Indoles/chemical synthesis , Organic Chemistry PhenomenaABSTRACT
Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined using a variety of spectroscopic methods. Compound 2 exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Aspergillus clavatus F 318a at a concentration of 50 µg per disk.
Subject(s)
Anti-Bacterial Agents/pharmacology , Antifungal Agents/pharmacology , Hypocreales/chemistry , Polyketides/chemistry , Anti-Bacterial Agents/chemistry , Antifungal Agents/chemistry , Aspergillus/drug effects , Japan , Magnetic Resonance Spectroscopy , Molecular Structure , Staphylococcus aureus/drug effects , Stereoisomerism , Wood/microbiologyABSTRACT
A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1-6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 µM (n = 2) and HL60 at 20 µM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 µM, respectively. Compound 6 was the most active with an IC50 of 4.6 µM on HeLa.
Subject(s)
Albizzia/metabolism , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Flavonoids/chemistry , Flavonoids/pharmacology , Steroids/chemistry , Steroids/pharmacology , Albizzia/chemistry , Benzopyrans/chemistry , Benzopyrans/isolation & purification , Benzopyrans/pharmacology , Cell Proliferation/drug effects , Drug Screening Assays, Antitumor/methods , Flavonoids/isolation & purification , HL-60 Cells , HeLa Cells , Humans , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Molecular Structure , Secondary MetabolismABSTRACT
Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig's base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
Subject(s)
Organic Chemicals/chemistry , Silica Gel/chemistry , Solvents/chemistry , Aldehydes/chemistry , Catalysis , Nitric Acid/chemistryABSTRACT
2-Trifluoromethyl-N-tosylaziridine reacted with various aldehydes in the presence of a catalytic amount of AgSbF(6) to provide the corresponding cis-4-trifluoromethyl-2-substituted-N-tosyl-1,3-oxazolidines with excellent regio- and stereoselectivity.
ABSTRACT
N-Methylation by sequential treatment of 5-tributylstannyl-4-fluoro-1H-pyrazole 1 with LDA and iodomethane regioselectively afforded the compound 2a in high yield. The addition reaction of 5-lithiated-4-fluoro-1H-pyrazole generated from 2a with a wide range of electrophiles allowed a facile introduction of different substituents at position 5 in good yields. The adduct 3d was efficiently converted to N-methyl-chromeno[2,3-d]pyrazol-9-one 9 in 3 steps.
Subject(s)
Pyrazoles/chemical synthesis , Magnetic Resonance Spectroscopy , Pyrazoles/chemistryABSTRACT
The palladium catalyzed cross-coupling reactions of aryl iodides and 5-tributylstannyl-4-fluoropyrazole prepared from fluoro(tributylstannyl)acetylene proceeded smoothly giving the corresponding 5-aryl-4-fluoropyrazole in good yields.
Subject(s)
Palladium/chemistry , Pyrazoles/chemistry , Acetone/analogs & derivatives , Acetone/chemistry , Catalysis , Hydrogen Bonding , Molecular StructureABSTRACT
A new and efficient chiral catalyst system, lanthanum-chiral BINOL-tris(4-fluorophenyl)phosphine oxide-cumene hydroperoxide, was developed for the epoxidation of alpha, beta-unsaturated ketones thus providing the corresponding epoxy ketones with excellent enantioselectivities (up to >99% ee) in good to excellent yields at room temperature.
ABSTRACT
A highly efficient and practical method for obtaining alpha,beta-epoxy ketones with high optical purities was developed. The chiral lanthanum complex self-organized in situ from lanthanum triisopropoxide, (R)-BINOL, triarylphosphine oxide, and alkyl hydroperoxide (1:1:1:1) was found to catalyze the epoxidation of alpha,beta-unsaturated ketones with tert-butyl hydroperoxide or cumene hydroperoxide at room temperature to give the corresponding epoxy ketones in high enantioselectivities (up to >99% enantiomeric excess (ee)). A remarkably high asymmetric amplification, a positive nonlinear effect, was observed in the epoxidation of chalcone, which strongly suggests the formation of a dinuclear peroxide-involved mu-complex as the active catalyst.