Subject(s)
Allergens/adverse effects , Araceae/adverse effects , Hypersensitivity/etiology , Adult , Female , Flowers , Humans , Plant Leaves , Plant StemsABSTRACT
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Subject(s)
Humans , Female , Adult , Allergens/adverse effects , Araceae/adverse effects , Hypersensitivity/etiology , Flowers , Plant Leaves , Plant StemsSubject(s)
Bites and Stings/diagnosis , Bites and Stings/therapy , Venoms/immunology , Venoms/therapeutic use , Anaphylaxis/diagnosis , Anaphylaxis/etiology , Anaphylaxis/immunology , Anaphylaxis/therapy , Animals , Bites and Stings/immunology , Desensitization, Immunologic/methods , Female , Humans , Immunotherapy/methods , Middle Aged , Wasps/immunologyABSTRACT
Aniseed is a spice native to the eastern Mediterranean region. Cases of simultaneous hypersensitivity to celery, mugwort pollen, and spices of the Umbelliferae family have been described as the celery-mugwort-spices syndrome. We report a case of aniseed-induced tongue angioedema. Skin prick tests to foods proved positive only to aniseed. Serum-specific immunoglobulin (Ig) E determination by enzyme allergosorbent test was 0.4 kU/L to aniseed extract and 0.6 kU/L to tare and cumin seeds. The molecular mass of the IgE-binding proteins studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) immunoblotting revealed a broad IgE-binding band of 12.9-13.7 kd in aniseed and tare extract assays and a broad band of 15-17.5 kd in cumin extract. This is the first case of type I hypersensitivity due to aniseed liqueur ingestion reported. SDS-PAGE immunoblotting study showed a broad specific IgE-binding band of 12.9-13.7 kd when aniseed extract was incubated with the patient's serum; this band might correspond to the protein responsible for the described symptoms.
