Prevalence of Intoxicating Substance Use Before or During Sex Among Young Adults: A Systematic Review and Meta-Analysis.

Drug use before or during sex is a high-risk sexual behavior associated with adverse health risks and outcomes, such as increasing the likelihood of overdoses and of acquiring sexually-transmitted diseases. This systematic review and meta-analysis of three scientific databases examined the prevalence of the use of intoxicating substances, those tending to excite or stupefy the user on a psychoactive level, before or during sex, among young adults (18-29 years old). A total of 55 unique empirical studies met the inclusion criteria (48,145 individuals; 39% males), were assessed for risk of bias using the tools of Hoy et al. (2012), and were analyzed via a generalized linear mixed-effects model. The results produced a global mean prevalence of this sexual risk behavior of 36.98% (95% CI: 28.28%, 46.63%). Nonetheless, significant differences were identified between different intoxicating substances, with the use of alcohol (35.10%; 95% CI: 27.68%, 43.31%), marijuana (27.80%; 95% CI: 18.24%, 39.92%), and ecstasy (20.90%; 95% CI: 14.34%, 29.45%) significantly more prevalent than that of cocaine (4.32%; 95% CI: 3.64%, 5.11%), heroin (.67%; 95% CI: .09%, 4.65%), methamphetamine (7.10%; 95% CI: 4.57%, 10.88%), and GHB (6.55%; 95% CI: 4.21%, 10.05%). Moderator analyses showed that the prevalence of alcohol use before or during sex differed according to geographical sample origin, and increased as the proportion of ethnic whites in samples increased. The remaining demographic (e.g., gender, age, reference population), sexual (e.g., sexual orientation, sexual activity), health (e.g., drug consumption, STI/STD status), methodological (e.g., sampling technique), and measurement (e.g., timeframe) variables that were examined did not moderate prevalence estimates. Implications for sexual development interventions were discussed.

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis.

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated towards Trypanosoma cruzi and Trichomonas vaginalis. Thiosemicarbazide 31 showed the best trypanocidal profile (epimastigotes), similar to benznidazole (BZ): IC50 (31)=28.72 µM (CL-B5 strain) and 33.65 µM (Y strain), IC50 (BZ)=25.31 µM (CL-B5) and 22.73 µM (Y); it lacked toxicity over mammalian cells (CC50 > 256 µM). Thiosemicarbazones 49, 51 and 63 showed remarkable trichomonacidal effects (IC50 =16.39, 14.84 and 14.89 µM) and no unspecific cytotoxicity towards Vero cells (CC50 ≥ 275 µM). Selenoisosters 74 and 75 presented a slightly enhanced activity (IC50=11.10 and 11.02 µM, respectively). Hydrogenosome membrane potential and structural changes were analysed to get more insight into the trichomonacidal mechanism.

Measurement Invariance and Latent Mean Differences Between American, Spanish and Chinese Adolescents Using the Social Anxiety Scale for Adolescents (SAS-A).

BACKGROUND: Social anxiety is one of the most prevalent disorders among adolescents (Stein et al., 2017). The main aim of this study was to analyze the equivalence of scores on the Social Anxiety Scale for Adolescents (SAS-A) using structural equation modeling and identify differences in latent means of social anxiety in China, Spain, and the USA. METHOD: Random sampling was used to recruit participants, which included 536 Chinese (46% girls), 1,178 Spanish (55.3% girls) and 866 North American (55.1% girls) adolescents. The participants' ages ranged between 14 and 17 years old. RESULTS: The SAS-A three-factor correlated model of social anxiety remained invariant between the Spanish and North American adolescents, but results could not be replicated in the Chinese adolescents [M2 = ΔS-Bχ² (Δdf, p) = 4732.56 (36, < .01)]. Analyses of latent differences between Spain and the USA showed that Spanish adolescents had higher scores than North Americans for Fear of Negative Evaluation (TS = -9.630; d = .44) and for Social Avoidance and General Anxiety towards people (TS = -2.717; d = .12). CONCLUSIONS: The results are interpreted according to the cultural traits of individualism-collectivism and self-construal, and practical implications are discussed.

Measurement Invariance and Latent Mean Differences Between American, Spanish and Chinese Adolescents Using the Social AnxietyScale for Adolescents (SAS-A) / Análisis de Invarianza y Diferencias de Medias Latentes Entre Adolescentes Americanos, Españoles y Chinos Usando la Escala deAnsiedad Social para Adolescentes (SAS-A)

Background: Social anxiety is one of the most prevalent disorders amongadolescents (Stein et al., 2017). The main aim of this study was to analyzethe equivalence of scores on the Social Anxiety Scale for Adolescents(SAS-A) using structural equation modeling and identify differences inlatent means of social anxiety in China, Spain, and the USA. Method:Random sampling was used to recruit participants, which included 536Chinese (46% girls), 1,178 Spanish (55.3% girls) and 866 North American(55.1% girls) adolescents. The participants’ ages ranged between 14 and17 years old. Results: The SAS-A three-factor correlated model of socialanxiety remained invariant between the Spanish and North Americanadolescents, but results could not be replicated in the Chinese adolescents[M2 = ΔS-Bχ2 (Δdf, p) = 4732.56 (36, < .01)]. Analyses of latent differencesbetween Spain and the USA showed that Spanish adolescents had higherscores than North Americans for Fear of Negative Evaluation (TS = -9.630;d = .44) and for Social Avoidance and General Anxiety towards people(TS = -2.717; d = .12). Conclusions: The results are interpreted accordingto the cultural traits of individualism-collectivism and self-construal, andpractical implications are discussed.

Antecedentes: la ansiedadsocial es uno de los trastornos con mayor prevalencia en adolescentes(Stein et al., 2017). Así, el propósito principal de este estudio fue analizarla invarianza de la Escala de Ansiedad Social para Adolescentes (SAS-A) mediante un modelo de ecuaciones estructurales y examinar las diferenciasde medias latentes en ansiedad social en adolescentes de China, España y EE.UU. Método: los participantes se seleccionaron a través de muestreoaleatorio: 534 chinos (46% chicas), 1.178 españoles (55,3% chicas) y866 norteamericanos (55,1% chicas), con edades comprendidas entre los14 y 17 años. Resultados: las puntuaciones del modelo de tres factorescorrelacionados de ansiedad social de la SAS-A resultaron invariantesentre adolescentes españoles y norteamericanos, pero estos resultados nofueron replicados en adolescentes chinos [M2 = ΔS-Bχ2 (Δdf, p) = 4732.56(36, < .01)]. El análisis de medias latentes entre España y EE.UU. mostróque los adolescentes españoles manifestaban niveles más altos de Miedoante las evaluaciones negativas (TS = -9.630; d = .44) y Evitación social yansiedad general hacia las personas (TS = -2.717; d = .12).Conclusiones: estos hallazgos fueron interpretados atendiendo al de individualismo-colectivismo y las concepciones culturales de la propia persona, analizandosus implicaciones prácticas.

Factor Invariance of the Trait Meta-Mood Scale-24 in a Sample of Chilean Adolescents.

The purpose of this study is to adapt the Trait Meta-Mood Scale-24 (TMMS-24; Fernández-Berrocal, Extremera, & Ramos, 2004, Spanish short version of the TMMS, Salovey, Mayer, Goldman, Turvey, & Palfai, 1995) to the Chilean adolescent population (13-17 years), analyzing the psychometric properties of the instrument through confirmatory factor analyses, factor invariance analysis, and latent mean differences. For this purpose, a sample of 3,255 secondary and high school students, between 12 and 18 years old (M = 15.28, SD = 1.24), were recruited. The results confirm the measurement invariance and structure of TMMS-24 scores by sex and age. The results of the latent mean analysis show the existence of significant differences associated with sex and age in the TMMS-24 attention to feelings factor. The adequate psychometric properties of the TMMS-24 show that it is valid for the Chilean adolescent population, thus covering the existing gap in this context.

Self-Description Questionnaire II (versión breve): evidencia de fiabilidad y validez en una muestra de adolescentes chilenos / Self-Description Questionnaire II (short version): evidence of reliability and validity in a sample of chilean adolescents

El objetivo de este estudio fue analizar la fiabilidad y validez de las puntuaciones de la versión breve del Self-Description Questionnaire II (SDQ-II-S) en población chilena. La muestra se compuso de 1255 adolescentes chilenos, con un rango de edad de 13 a 17 años (M=15.10; DT=1.30). El análisis factorial confirmatorio corroboró la estructura original de 11 factores correlacionados del SDQ-II-S. La multidimensionalidad del cuestionario también fue avalada por la pequeña magnitud de las correlaciones entre los 11 factores (M = 0.26). Los coeficientes alfa de Cronbach variaron desde 0.70 hasta 0.84, y se destacó una adecuada fiabilidad. Para profundizar en el análisis de la validez de constructo del SDQ-II-S, se relacionaron las puntuaciones de las diferentes escalas con puntuaciones en medidas de ansiedad (Inventario de Ansiedad Estado-Rasgo) y autoeficacia (Escala de Autoeficacia Percibida Específica de Situaciones Académicas). Los resultados pusieron de manifiesto que estos cuestionarios permiten analizar constructos diferenciados aunque relacionados. Los datos de este trabajo destacan que el SDQ-II-S presenta adecuadas propiedades psicométricas en población chilena, contrarrestando las carencias existentes en lo que respecta a la evaluación del autoconcepto, y resaltan interesantes aplicaciones tanto en el ámbito aplicado como en el de la investigación.