ABSTRACT
BACKGROUND: Congenital glioblastoma (cGBM) is a brain tumor very rarely observed in newborns and young infants, and differs in several respects from glioblastoma (GBM) of childhood and adulthood. Our aim was the presentation of a cGBM case with 14 days of postnatal survival at the Pediatric Oncology Center of the Markusovszky University Teaching Hospital in 2004. We investigated formalin-fixed, paraffin-embedded autoptic tumor samples of the newborn by immunohistochemical and molecular genetic (FISH and pyrosequencing) methods. We found polysomy of chromosome 2 and 5' deletion of the ALK gene in the glioma cells by ALK FISH. This result indicates the importance of molecular analyses in the diagnostic evaluation of cGBM, and raises the possibility of a personalized, targeted therapy (crizotinib, alectinib).
Subject(s)
Brain Neoplasms , Glioblastoma , Adult , Brain Neoplasms/genetics , Brain Neoplasms/therapy , Crizotinib , Glioblastoma/congenital , Glioblastoma/genetics , Glioblastoma/pathology , Humans , Infant, Newborn , Receptor Protein-Tyrosine Kinases/geneticsSubject(s)
Cryptococcosis/microbiology , Cryptococcus , Dermatomycoses/microbiology , Facial Dermatoses/microbiology , Hand Dermatoses/microbiology , Scalp Dermatoses/microbiology , Aged, 80 and over , Antifungal Agents/therapeutic use , Cryptococcosis/diagnosis , Dermatomycoses/diagnosis , Facial Dermatoses/diagnosis , Fluconazole/therapeutic use , Hand Dermatoses/diagnosis , Humans , Male , Scalp Dermatoses/diagnosisABSTRACT
Authors present a rare manifestation of the temporal arteritis, wich caused initial diagnostic difficulties, but it responded well for corticosteroid treatment. The features of the disease, pathogenesis, possible therapy are briefly summarized beside the description of clinical course. Orv. Hetil., 2017, 158(2), 77-80.