ABSTRACT
Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-ß1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-ß1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations. TGF-ß1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with fibrotic diseases. Dogs with diabetes mellitus and fibrotic diseases have significantly increased TGF-ß1 serum concentrations compared to healthy controls. Some dogs with diabetes mellitus showed increased expression of TGF-ß1 receptor in lens capsule. Based on our observations we can conclude that TGF-ß1 elevation in dogs with diabetes mellitus may induces complications of the disease and may participates on lens alteration.