ABSTRACT
BACKGROUND: Pancreatic intraductal papillary mucinous neoplasms (IPMN), morphologically resembling colonic adenomas, often have an indefinable malignant potential. We used a monoclonal antibody (MAb) raised against colonic adenomas, Adnab-9, to identify patients with a better prognosis. METHODS: We assessed Adnab-9-labeled sections of these neoplasms from 50 patients, 13 pancreatic adenocarcinomas, and 32 colonic adenomas using standard immunohistochemical techniques. RESULTS: 26% of the IPMNs labeled with Adnab-9 as compared to 0% of pancreatic ductal cancers or surrounding benign tissues, (p < 0.001) and 53% of adenomas (p < 0.025). Labeling in IPMNs was usually seen in the noninvasive epithelium suggesting that Adnab-9 is a premalignant marker in these lesions. Labeling of invasive IPMN's identified a group of patients with a superior overall survival (p = 0.027). CONCLUSION: Adnab-9 labeling-characteristics appear similar for both IPMNs and adenomatous polyps, suggesting that they are analogous lesions. Adnab-9 labeling may also be a useful prognostic marker for invasive intraductal papillary mucinous neoplasms.
Subject(s)
Adenocarcinoma, Mucinous/metabolism , Adenocarcinoma, Mucinous/pathology , Antibodies, Monoclonal , Pancreatic Neoplasms/metabolism , Pancreatic Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Defensins/metabolism , Female , Humans , Immunohistochemistry , Male , Middle Aged , PrognosisABSTRACT
INTRODUCTION: Fine needle aspirations (FNAs) and endoscopic retrograde cholangiopancreatography (ERCP)-guided brushings (BRUSH) are useful tools in the differentiation between malignant and benign disease of the pancreas. Once the decision to obtain a cytologic confirmation of one's clinical suspicion is made, the interpretation of the findings, especially an equivocal or negative cytology finding, can be unclear. This study seeks to evaluate the utility of cytologic studies in the evaluation of a patient with suspected pancreatic malignancy. METHODS: A retrospective review of 224 cytologic reports, including 174 FNAs and 50 BRUSHs, from all pancreatic FNAs and BRUSHs performed between January 1989 and June 1995, was performed. Subsequent confirmation of the cytologic diagnosis was made either by histologic or strict clinical criteria. RESULTS: Forty-three percent of the cytologic reports were read as malignant, all others reported as suspicious, atypical, or negative. All cytology studies read as malignant and all FNAs reported as suspicious were histologically or clinically confirmed to be malignant. Of those reported as atypical or negative, 55% and 49% were confirmed to be malignant. Both FNA and BRUSH were 100% specific, 75% sensitive, and 80% accurate. CONCLUSIONS: We conclude that a cytological diagnosis of malignant or suspicious is reliable and useful for further therapy planning in the patient suspected to have a pancreatic malignancy. The reason for the cytologic tests was a strong clinical suspicion, therefore, a high incidence of cancer was found in the patients with atypical or negative readings. A diagnosis of atypical or negative is equivocal and requires further diagnostic maneuvers, frequently including surgery, to make the definitive diagnosis.
Subject(s)
Pancreas/pathology , Pancreatic Neoplasms/pathology , Biopsy, Needle , Cholangiopancreatography, Endoscopic Retrograde , Humans , Predictive Value of Tests , Retrospective StudiesABSTRACT
A case of locally extensive perianal Paget's disease is presented. Initial wide local excision, guided by frozen sections, was inadequate. Multiple punch biopsies subsequently revealed extensive circumferential involvement of the anoderm by Paget's disease, making wide local excision difficult. Therefore, the patient was treated with combined chemoradiotherapy (5000 cGy, 5-fluorouracil, and mitomycin C). Fourteen months after treatment, the patient had a complete response.
Subject(s)
Anus Neoplasms/drug therapy , Anus Neoplasms/radiotherapy , Paget Disease, Extramammary/drug therapy , Paget Disease, Extramammary/radiotherapy , Aged , Anus Neoplasms/pathology , Combined Modality Therapy , Fluorouracil/therapeutic use , Humans , Male , Mitomycin , Mitomycins/therapeutic use , Paget Disease, Extramammary/pathology , Radiotherapy DosageABSTRACT
The case of a 34-year-old kidney transplant patient who developed carcinoma in situ of the cervix after immunosuppressive therapy with azathioprine is reported. A few case reports and studies of this association have appeared previously in the literature, in addition to many reports associating azathioprine treatment with other malignant tumors. This report reemphasizes this association and the need for close surveillance of patients undergoing immunosuppressive therapy. The pertinent literature on the association of chronic use of immunosuppressive agents with the subsequent development of malignant tumors is briefly reviewed.
