ABSTRACT
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10-8) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL by heavy menstrual bleeding in 3409 cases and 199,171 female controls reveals genome-wide significant associations at three of the 29 UL loci: 5p15.33 (TERT), 5q35.2 (FGFR4) and 11q22.3 (ATM). Four loci identified in the meta-analysis are also associated with endometriosis risk; an epidemiological meta-analysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a history of endometriosis. These findings increase our understanding of genetic contribution and biology underlying UL development, and suggest overlapping genetic origins with endometriosis.
Subject(s)
Endometriosis/genetics , Leiomyoma/genetics , Uterine Neoplasms/genetics , Adult , Ataxia Telangiectasia Mutated Proteins/genetics , Endometriosis/epidemiology , Female , Forkhead Box Protein O1/genetics , Forkhead Box Protein O1/metabolism , Genome-Wide Association Study , Humans , Leiomyoma/complications , Leiomyoma/epidemiology , Mendelian Randomization Analysis , Menorrhagia/etiology , Middle Aged , Polymorphism, Single Nucleotide , Proportional Hazards Models , Receptor, Fibroblast Growth Factor, Type 4/genetics , Signal Transduction , Telomerase/genetics , Uterine Neoplasms/complications , Uterine Neoplasms/epidemiology , White People/geneticsABSTRACT
A technique describing the application of an autopolymerizing silastic material for the fabrication of a customized interpositional alloplastic implant for TMJ gap arthroplasty has been presented. The implant is easily stabilized, shows no adverse tissue reaction, and remains undisplaced under function. The implant is quickly constructed and accurately adapted to the bony architecture of the temporal bone and condylar segments.
Subject(s)
Ankylosis/surgery , Arthroplasty/methods , Prostheses and Implants , Silicone Elastomers , Temporomandibular Joint Disorders/surgery , Adult , Female , HumansABSTRACT
Etomidate, a nonnarcotic, nonbarbiturate hypnotic agent, was assessed in a group of 20 patients requiring general anesthesia for outpatient oral surgical procedures. Changes in mean blood pressure, heart rate, and transcutaneous oxygen tension (PtcO2) were examined following the intravenous administration of etomidate for the induction and maintenance of general anesthesia. Clinical evidence of pain on injection, myoclonic muscle activity, apnea, nausea, and emesis were documented. A postoperative questionnaire evaluated levels of amnesia and acceptance of the drug by the patient and surgeon. No significant (P less than 0.05) change in PtcO2 occurred during etomidate infusion; however, a statistically significant but clinically insignificant change did occur in mean blood pressure and heart rate. Although myoclonic muscle activity, pain on injection, and nausea and vomiting were documented, the subjective evaluation of this agent by patient and surgeon was favorable.
Subject(s)
Anesthesia, Dental , Anesthesia, Intravenous , Etomidate , Adolescent , Adult , Blood Pressure/drug effects , Consumer Behavior , Etomidate/adverse effects , Etomidate/pharmacology , Female , Heart Rate/drug effects , Humans , Male , Memory/drug effects , Oxygen/bloodSubject(s)
Carcinoma, Squamous Cell/diagnosis , Gingival Neoplasms/diagnosis , Neoplasms, Multiple Primary/diagnosis , Periodontal Diseases/diagnosis , Carcinoma, Squamous Cell/pathology , Diagnostic Errors , Gingival Neoplasms/pathology , Humans , Male , Middle Aged , Mouth Floor/pathology , Mouth Neoplasms/pathology , Neoplasms, Multiple Primary/pathology , Periodontal Diseases/pathology , Tongue Neoplasms/pathologyABSTRACT
A root-end induction procedure was used to treat a nonvital tooth with an open apex. This procedure was relatively fast and simple and did not require special instruments or medicaments. The procedure improved the prognosis of the involved tooth and reduced the trauma associated with surgical endodontic treatment.