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s.l; s.n; 2005. 10 p. ilus, tab.
Non-conventional in English | Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1241662

ABSTRACT

Antimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum antimicrobial activity against bacteria, viruses, and fungi. These evolutionarily conserved peptides are usually positively charged and have both a hydrophobic and hydrophilic side that enables the molecule to be soluble in aqueous envirenments yet also enter lipid-rich membranes. Once in a target microbial membrane, the peptide kills target cel through diverse mechanisms. Cathelicidins and defensins are major groups of epidermal AMPs. Decreased levels of these peptides have been noted for patients with atopic dermatitis and Kostmann's syndrome, a congenital neutropenia. In addition to important antimicrobial properties, growing evidence indicates that AMPs alter the host immune response through receptor-dependent interactions. AMPs have been shown to be important in such diverse functions as angiogenesis, wound healing, and chemotaxis. As our knowledge of AMO biology expands, the precise role and relevance of these peptides will be better elucidated


Subject(s)
Humans , Anti-Infective Agents/pharmacology , Anti-Infective Agents/therapeutic use , Skin Diseases/drug therapy , Immunologic Factors/pharmacology , Immunologic Factors/therapeutic use , Skin/metabolism , Antimicrobial Cationic Peptides/pharmacology , Antimicrobial Cationic Peptides/physiology , Antimicrobial Cationic Peptides/therapeutic use
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