ABSTRACT
EBV-positive diffuse large B-cell lymphoma (DLBCL) in elderly is a new entity included provisionally in the most recent WHO Classification of lymphoid neoplasms. It usually affects elderly patients and has a poor survival. The goal of this report was to evaluate clinical, endoscopic characteristics and survival of five patients with this entity and gastrointestinal afectation. From five cases, three cases had gastric infiltration, one ileon and one in cecum.
Subject(s)
Epstein-Barr Virus Infections/complications , Lymphoma, Large B-Cell, Diffuse/diagnosis , Adult , Aged , Aged, 80 and over , Cecal Neoplasms/diagnosis , Cecal Neoplasms/mortality , Cecal Neoplasms/virology , Female , Humans , Ileal Neoplasms/diagnosis , Ileal Neoplasms/mortality , Ileal Neoplasms/virology , Lymphoma, Large B-Cell, Diffuse/mortality , Lymphoma, Large B-Cell, Diffuse/virology , Male , Middle Aged , Retrospective Studies , Stomach Neoplasms/diagnosis , Stomach Neoplasms/mortality , Stomach Neoplasms/virologyABSTRACT
El Linfoma de Células Grandes B difuso del anciano asociado al Epstein Barr es una nueva entidad incluida provisionalmente en la más reciente clasificación de neoplasias linfoides de la WHO. Usualmente afecta ancianos y tiene pobre sobrevida. El objetivo de este reporte fue evaluar las característica clínicas, endoscópicas y sobrevida de cinco pacientes portadores de esta entidad y compromiso gastrointestinal. Tres casos tuvieron infiltración gástrica y dos casos tuvieron compromiso del ileón y el ciego.
EBV-positive diffuse large B-cell lymphoma (DLBCL) in elderly is a new entity included provisionally in the most recent WHO Classification of lymphoid neoplasms. It usually affects elderly patients and has a poor survival. The goal of this report was to evaluate clinical, endoscopic characteristics and survival of five patients with this entity and gastrointestinal afectation. From five cases, three cases had gastric infiltration, one ileon and one in cecum.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Epstein-Barr Virus Infections/complications , Lymphoma, Large B-Cell, Diffuse/diagnosis , Cecal Neoplasms/diagnosis , Cecal Neoplasms/mortality , Cecal Neoplasms/virology , Ileal Neoplasms/diagnosis , Ileal Neoplasms/mortality , Ileal Neoplasms/virology , Lymphoma, Large B-Cell, Diffuse/mortality , Lymphoma, Large B-Cell, Diffuse/virology , Retrospective Studies , Stomach Neoplasms/diagnosis , Stomach Neoplasms/mortality , Stomach Neoplasms/virologyABSTRACT
Introducción: El virus del papiloma humano (VPH) es un agente involucrado en la patogénesis del cáncer de cérvix. Varios reportes describen una asociación entre VPH y carcinoma escamoso de esófago (CEE). Objetivo: determinar la frecuencia de infección del PVH de alto riesgo y el CEE. Material y método: se realizó un estudio retrospectivo del universo de caso, n= 29 de CEE diagnosticados del 2003 al 2006 con estudio anatomopatológico en el Hospital Edgardo Rebagliati Martins, Lima, Perú. La muestras parafinadas fueron sometidas a PCR-RT para la detección de PVH 16,18,31,33 y 45 . Resultados: la edad media fue de 73 años, la relación masculino/femenino fue 3. Los estadios fueron : estadio I :1 caso; estadio II: 12 casos, estadio III:14 casos y estadio IV: 2 casos. No se detectó en ningún caso VPH de alto riesgo a pesar de emplear dos sondas diferentes. Conclusión: el VPH no fue detectado en CEE en el universo de casos estudiados.
Introduction: Human papilloma virus (HPV) is an agent involved in the pathophysiology of cervical cancer. Many reports describe an association between HPV and esophageal squamous-cell carcinoma (ESCC). Objective: The main objective of the study is to determine the frequency of high-risk HPV infection and ESCC. Material and method: A retrospective study including 29 ESCC cases with a histological and pathological diagnosis from 2003 to 2006 in Edgardo Rebagliati-Martins Hospital in Lima, Peru. Paraffin-mbedded tissue fragments underwent RT-PCR tests for detecting HPV types 16, 18, 31, 33, and 45. Results: Mean age of patients was 73 years, male to female ratio was 3. Stage I disease was found in one case; stage II disease in 12 cases, stage III disease in 14 cases, and stage IV in 2. No highrigh HPV was found in any of the samples studied, even though we used two different probes. Conclusion: HPV was not detected in ESCC in the population studied.