ABSTRACT
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Subject(s)
Humans , Male , Female , Young Adult , Middle Aged , Aged , Photopheresis/methods , Graft Rejection/therapy , Kidney Transplantation/adverse effects , Retrospective Studies , Risk Factors , Creatinine/blood , Treatment Outcome , Reproducibility of ResultsABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Solitary Pulmonary Nodule/diagnostic imaging , Solitary Pulmonary Nodule/microbiology , Kidney Transplantation/adverse effects , Cryptococcosis/diagnostic imaging , Cryptococcosis/complications , Tomography, X-Ray ComputedSubject(s)
Graft Rejection/therapy , Kidney , Photopheresis/methods , Transplant Recipients , Chronic Disease , Female , Humans , Immunity, Cellular , Kidney Transplantation , Male , Middle Aged , Retrospective Studies , Young AdultABSTRACT
Introducción: Ciertos polimorfismos de los genes de la miosina no muscular de tipo IIA (MYH9) y de la apolipoproteína L1 (APOL1) se han asociado con la enfermedad renal crónica (ERC) en distintas poblaciones. Este estudio evaluó la asociación entre los polimorfismos rs2032487 de MYH9 y rs73885319 de APOL1 con la ERC avanzada asociada a diabetes tipo 2 en una población de Gran Canaria. Material y métodos: Los polimorfismos se genotiparon en 152 pacientes con ERC avanzada (filtrado glomerular estimado [FGe] < 30 ml/min/1,73 m2) secundaria a diabetes tipo 2, 110 pacientes con diabetes tipo 2 con evolución ≥ 20 años sin ERC avanzada (FGe ≥ 45 ml/min/1,73 m2 y ausencia de proteinuria) y 292 hemodonantes sanos de más de 50 años sin ERC ni diabetes. Resultados: La frecuencia del alelo de riesgo de rs2032487 fue de 10,7% entre pacientes con diabetes y ERC avanzada, 7,1% en aquellos con diabetes sin ERC avanzada y 6,1% en los sujetos sanos, alcanzándose diferencias significativas entre el primer y el tercer grupo (P = 0,015). El 78,5% de los sujetos con ERC avanzada eran homocigotos para el alelo protector, frente al 87,9% en los otros dos grupos (P = 0,015 y P = 0,016, respectivamente). La frecuencia del alelo de riesgo del polimorfismo rs73885319 no superó el 0,5% en ninguno de los tres grupos. Conclusiones: Estos datos sugieren que el polimorfismo rs2032487 se asocia con la ERC avanzada asociada a diabetes tipo 2 en la población de Gran Canaria
Introduction: Certain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain). Patients and methods: Polymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) secondary to T2DM, 110 patients with T2DM onset ≥ 20 years before without advanced CKD (eGFR ≥ 45 mL/min/1.73 m2 and no proteinuria), and 292 healthy blood donors over 50 years of age without CKD or diabetes. Results: The frequency of the risk allele for rs2032487 was 10.7% in patients with diabetes and advanced CKD, 7.1% in those with diabetes but without advanced CKD, and 6.1% in healthy subjects, with significant differences between the first and third groups (P = .015). Among subjects with advanced CKD, 78.5% were homozygous for the protective allele, as compared to 87.9% in the other two groups (P = .015 and P = .016 respectively). The frequency of the risk allele for the rs73885319 polymorphism did not exceed 0.5% in any of the three groups. Conclusions: These data suggest that polymorphism rs2032487 is associated to advanced CKD related to T2DM in the population of Gran Canaria
Subject(s)
Humans , Male , Adult , Middle Aged , Aged , Polymorphism, Single Nucleotide , Renal Insufficiency, Chronic/genetics , Diabetes Mellitus, Type 2/genetics , Genetic Predisposition to Disease , Renal Insufficiency, Chronic/complications , Glomerular Filtration Rate , Diabetic Retinopathy/diagnosis , Genotyping Techniques , Odds Ratio , 28599ABSTRACT
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Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Diuretics/therapeutic use , Metformin/pharmacokinetics , Acidosis, Lactic/chemically induced , Metformin/adverse effects , Renal Dialysis/methods , Diuretics/pharmacokineticsSubject(s)
Acidosis, Lactic/chemically induced , Diuretics/adverse effects , Hypoglycemic Agents/adverse effects , Metformin/adverse effects , Acidosis, Lactic/metabolism , Acidosis, Lactic/therapy , Acute Kidney Injury/physiopathology , Acute Kidney Injury/therapy , Aged , Contraindications, Drug , Diuretics/administration & dosage , Diuretics/metabolism , Female , Humans , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/metabolism , Male , Metformin/administration & dosage , Metformin/metabolism , Renal DialysisABSTRACT
Background: Frailty is an aging-associated state of increased vulnerability, which raises the risk of adverse outcomes. Chronic kidney disease is associated with higher prevalence of frailty. Our aim was to estimate frailty prevalence in a hemodialysis population and its influence on short-term outcomes. Design: Observational prospective longitudinal study of 277 prevalent hemodialysis patients. Frailty was estimated through the Edmonton Frail Scale (EFS). Demographic and clinical data, comorbidity index, and laboratory parameters were recorded. A 29-month follow-up was conducted on mortality, including hospitalization, and visits to hospital emergency services in the first 12 months of this period. Results: According to the EFS, 82 patients (29.6%) were frail, 53 (19.1%) were vulnerable, and 142 (51.3%) were non-frail. During follow-up, 58.5% frail patients, 30.2% vulnerable, and 16.2% non-frail ones died (p < .005). In the analysis of survival using an adjusted Cox model, a higher hazard of mortality was observed in frail than in non-frail patients (HR 2.34; 95% CI 1.39-3.95; p = .001). During follow-up the hospitalization rate was 852 episodes/1000 patient-years for frail patients, 784 episodes/1000 patient-years for vulnerable patients, and 417 episodes/1000 patient-years for non-frail patients (p = .0005). The incidence ratio of visits to emergency services was 3216, 1735, and 1545 visits/1000 patient-years for each group (p < .001). Conclusions: Hemodialysis patients present high frailty prevalence. Frailty is associated with poor short-term outcomes and higher rates of mortality, visits to hospital emergency services, and hospitalization.
Subject(s)
Frailty/epidemiology , Renal Dialysis/adverse effects , Renal Insufficiency, Chronic/complications , Aged , Emergency Service, Hospital/statistics & numerical data , Female , Frail Elderly/statistics & numerical data , Frailty/diagnosis , Frailty/etiology , Geriatric Assessment , Hospitalization/statistics & numerical data , Humans , Longitudinal Studies , Male , Middle Aged , Prevalence , Prospective Studies , Renal Insufficiency, Chronic/mortality , Renal Insufficiency, Chronic/therapy , Survival AnalysisABSTRACT
INTRODUCTION: Certain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain). PATIENTS AND METHODS: Polymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR]<30mL/min/1.73 m2) secondary to T2DM, 110 patients with T2DM onset ≥ 20 years before without advanced CKD (eGFR ≥ 45mL/min/1.73 m2 and no proteinuria), and 292 healthy blood donors over 50 years of age without CKD or diabetes. RESULTS: The frequency of the risk allele for rs2032487 was 10.7% in patients with diabetes and advanced CKD, 7.1% in those with diabetes but without advanced CKD, and 6.1% in healthy subjects, with significant differences between the first and third groups (P=.015). Among subjects with advanced CKD, 78.5% were homozygous for the protective allele, as compared to 87.9% in the other two groups (P=.015 and P=.016 respectively). The frequency of the risk allele for the rs73885319 polymorphism did not exceed 0.5% in any of the three groups. CONCLUSIONS: These data suggest that polymorphism rs2032487 is associated to advanced CKD related to T2DM in the population of Gran Canaria.
Subject(s)
Apolipoprotein L1/genetics , Diabetes Mellitus, Type 2/genetics , Diabetic Nephropathies/genetics , Myosin Heavy Chains/genetics , Polymorphism, Genetic , Renal Insufficiency, Chronic/etiology , Aged , Aged, 80 and over , Diabetes Mellitus, Type 2/complications , Female , Humans , Male , Middle Aged , SpainABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Aged , Frail Elderly/statistics & numerical data , Renal Dialysis , Prognosis , Renal Insufficiency, Chronic/epidemiology , Frailty/epidemiology , Follow-Up Studies , Frailty/mortality , Sarcopenia/complicationsABSTRACT
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Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Kidney Failure, Chronic/drug therapy , Kidney Failure, Chronic/etiology , Leptospirosis/complications , Leptospirosis/microbiology , Kidney Failure, Chronic/epidemiology , Renal Dialysis , Immunoglobulin M/analysis , Enzyme-Linked Immunosorbent Assay , Leptospira/isolation & purificationSubject(s)
Acute Kidney Injury/microbiology , Leptospirosis/complications , Aged , Female , Humans , Leptospirosis/diagnosis , Male , Middle Aged , Young AdultABSTRACT
OBJECTIVE: To study whether the score proposed by the International Society of Renal Nutrition and Metabolism to define the protein energy wasting (PEW) syndrome has diagnostic validity in patients undergoing dialysis. DESIGN AND METHODS: Cross-sectional study including 468 prevalent hemodialysis patients from Canary Islands, Spain. Individual PEW syndrome criteria and the number of PEW syndrome categories were related to other objective markers of PEW using linear and logistic regression analyses: subjective global assessment, handgrip strength, bioimpedance-assessed body composition, and levels of high-sensitivity C-reactive protein. RESULTS: Study participants (34% women) had a median age of 66 years, 37 months of maintenance dialysis, and 50% were diabetics. About 23% of patients had PEW (≥3 PEW categories), and 68% were at risk of PEW (1-2 PEW categories). Low prealbumin was the most frequently found derangement (52% of cases), followed by low albumin (46%), and low protein intake (35%). Across higher number of PEW syndrome categories, patients showed a longer dialysis vintage and had lower creatinine, triglycerides, and transferrin (P for trend <.001 for all). All nutritional assessments not included in the PEW definition worsened across higher number of PEW categories. In multivariable regression analyses, there was a linear inverse relationship between muscle and fat mass as well as handgrip strength with the number of PEW syndrome categories. Likewise, the proportion of subjective global assessment-defined malnutrition and serum concentration of C-reactive protein gradually increased despite adjustment for confounders (P for trend <.05 for all). CONCLUSION: The PEW score reflects systemic inflammation, malnutrition and wasting among dialysis patients and may thus be used for diagnostic purposes.
Subject(s)
Protein-Energy Malnutrition/complications , Protein-Energy Malnutrition/diagnosis , Protein-Energy Malnutrition/physiopathology , Renal Dialysis , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/therapy , Aged , C-Reactive Protein , Cross-Sectional Studies , Electric Impedance , Female , Hand Strength/physiology , Humans , Male , Middle Aged , Prevalence , SpainABSTRACT
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Subject(s)
Humans , Female , Pregnancy , Kidney Diseases/complications , Pregnancy Complications/diagnosis , Pregnancy Complications/physiopathology , Nephrolithiasis/complications , Antiphospholipid Syndrome/complications , Renal Plasma Flow/physiology , Glomerular Filtration Rate/physiology , Proteinuria/diagnosisABSTRACT
BACKGROUND/AIMS: Different biochemical abnormalities of metabolic bone disease have been associated with anemia of chronic kidney disease (CKD), mainly in hemodialysis patients. However, all of these abnormalities are closely inter-related and their individual effect on the development of anemia is uncertain. This study was aimed to assess the relationship between anemia and a set of metabolic bone disease biomarkers in a cohort of adult patients with advanced non-dialysis-dependent CKD. METHODS: The sample consisted of 382 patients submitted to a Nephrology Unit for evaluation of advanced CKD in a tertiary hospital from Gran Canaria during 3 years. Associations between anemia and serum levels of calcium (albumin-corrected), phosphorus, PTH, 25-hydroxivitamin D (25(OH)D3) and alkaline phosphatase were analyzed by using logistic regression models with adjustment for other demographic, clinical and biochemical covariates potentially related to anemia and to bone mineral metabolism. RESULTS: Serum levels of calcium and 25(OH)D3 (negatively) and phosphorus (positively) were significantly associated with anemia in an unadjusted logistic regression model. In a fully adjusted multivariable model, the OR for anemia was 0.29 (95% CI 0.16-0.49; p < 0.0001) for every 1 mg/dl increase in serum calcium and 2.19 (95% CI 1.55-3.15; p < 0.001) for every 1 mg/dl increase in serum phosphorus. Female sex and lower serum albumin levels were also independently associated with anemia. The inclusion of albumin in the adjusted model displaced the significance of 25(OH)D3. CONCLUSIONS: Circulating levels of calcium and phosphorus are strongly linked to anemia in patients with advanced non-dialysis CKD.
Subject(s)
Anemia/blood , Anemia/etiology , Calcium/blood , Phosphorus/blood , Renal Insufficiency, Chronic/blood , Renal Insufficiency, Chronic/complications , Aged , Biomarkers/blood , Bone Diseases, Metabolic/blood , Bone Diseases, Metabolic/complications , Calcifediol/blood , Cohort Studies , Female , Humans , Male , Middle AgedABSTRACT
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