ABSTRACT
A case of "epithelioid angiomatosis" detected in a homosexual patient with positive seric HIV is presented. The skin lesions cytoplasm rich, closed y clumped together, with scanty stromal compound. Warthin-Starry staining [correction of tintions] did not show Bacillus causing "cat scratch disease". We review and analyse the features of this type of proliferation in patients infected with HIV.
Subject(s)
Angiomatosis/complications , HIV Infections/complications , HIV-1 , Skin Neoplasms/diagnosis , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/diagnosis , Acquired Immunodeficiency Syndrome/pathology , Adult , Angiomatosis/diagnosis , Angiomatosis/pathology , HIV Infections/diagnosis , HIV Infections/pathology , HIV Seropositivity/complications , HIV Seropositivity/pathology , Homosexuality , Humans , Male , Neurosyphilis/complications , Neurosyphilis/pathology , Skin/pathology , Skin Neoplasms/pathologyABSTRACT
A man with previous addiction to parenteral drugs presented infection by human immunodeficiency virus (HIV) with persistent generalised lymph node enlargement. Sixteen months after diagnosis, he developed intermediate-grade lymphoma of the stomach. Partial response was achieved by chemotherapy, and the patient presented pulmonary and meningeal tuberculosis which led him to exitus.
Subject(s)
AIDS-Related Complex/complications , Lymphoma, Non-Hodgkin/etiology , Stomach Neoplasms/etiology , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bleomycin/administration & dosage , Cyclophosphamide/administration & dosage , Dexamethasone/administration & dosage , Doxorubicin/administration & dosage , Humans , Leucovorin/administration & dosage , Lymphoma, Non-Hodgkin/drug therapy , Male , Methotrexate/administration & dosage , Opportunistic Infections/complications , Stomach Neoplasms/drug therapy , Substance-Related Disorders/complications , Tuberculosis, Miliary/complications , Vincristine/administration & dosageABSTRACT
In 24 cases of thrombopenic purpura associated with human immunodeficiency virus infection the clinical, immunological and therapeutic features were evaluated. Thrombopenia resulted in clinical manifestations in 20 patients. Splenomegaly was found in only one fourth of patients. Antiplatelet antibodies were found in 9 patients, and thrombopenia was associated with anemia in 37% of cases and with leukopenia in 21%. Bone marrow examination showed megakaryocyte hyperplasia in two thirds of the patients. The major immunological abnormalities were an inverted helper/suppressor T lymphocytes ratio, a reduction in the number of helper T lymphocytes, polyclonal hypergammaglobulinemia, and increased serum concentrations of circulating immunocomplexes. The different therapeutic modalities, steroids, vincristine, danatrol and plasma exchange, resulted in short responses; only two patients had normal platelet counts. The median follow-up was 14 months; during this time three patients fulfilled the criteria of acquired immunodeficiency syndrome.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Purpura, Thrombocytopenic/complications , Acquired Immunodeficiency Syndrome/diagnosis , Adult , Female , Follow-Up Studies , Humans , Male , Plasma Exchange , Prednisone/therapeutic use , Purpura, Thrombocytopenic/diagnosis , Purpura, Thrombocytopenic/therapy , Time Factors , Vincristine/therapeutic useABSTRACT
An immunoradiometric assay was used to determine the presence of p29 protein in 68 breast cancer cyTOSOLS. The p29 values ranged from 0 to 1123 U/mg, with a mean value of 127 +/- 28.7 U/mg. Using a cutoff point of 20 U/mg the frequency of p29 positive tumors was about 55%. A quantitative and qualitative relation was found between p29 and estrogen receptor (ER), but not between p29 and progesterone receptor (PR). Discordance between p29 and ER status was found in 13 out of 68 tumors. Both the frequency of p29 positive tumors and the p29 values were significantly higher in postmenopausal than in premenopausal women, in a similar way to ER but different from PR. There was no difference in p29 content between primary tumor and metastasis. We did not find any relation among p29 primary tumors content and axillary lymph nodes involvement or tumor size.
