ABSTRACT
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a clinical entity with specific features that impacts significantly on patient quality of life (QoL). CRSwNP is often associated with asthma and is difficult to control and manage despite pharmacological and/or surgical treatment. Omalizumab, a monoclonal anti-IgE antibody, has emerged as a putative therapeutic option. OBJECTIVE: To evaluate the effects of omalizumab on nasal polyp (NP) size and QoL assessed by Sino-Nasal Outcome Test-22 (SNOT-22) in patients with recalcitrant CRSwNP and mild asthma. METHODS: A multicenter retrospective analysis of patient data from the Community of Valencia (Spain) was performed. Adult patients with recalcitrant CRSwNP and comorbid mild asthma receiving compassionate use of omalizumab were included. NP size measured by total nasal endoscopic polyp score (TPS) and QoL evaluated through the SNOT-22 questionnaire were assessed at baseline and monthly over 12 months. An ordinal regression model was built to analyze the results. RESULTS: A total of 23 CRSwNP patients with a mean age (± SD) of 54.78 ± 9.46 years were included. Nineteen suffered from aspirin-exacerbated respiratory disease (AERD). In all patients, a significant and sustained reduction in TPS was observed over time, accompanied by improvements in QoL reflected in lower SNOT-22 scores. In the ordinal regression model, time but not total IgE, age or tissue eosinophilia impacted on NP size and SNOT-22 outcomes. Additionally, improvements in QoL were not explained by reductions in the size of polyps. CONCLUSION: Omalizumab was effective for the treatment of patients with recalcitrant CRSwNP and mild asthma, even when AERD was present, by reducing NP size and improving QoL; treatment time was a key factor. SNOT-22 improvements were not explained by decreases in TPS, indicating that omalizumab may be effective in all patients, regardless of polyp size.
Subject(s)
Asthma , Nasal Polyps , Rhinitis , Adult , Asthma/complications , Asthma/drug therapy , Asthma/epidemiology , Chronic Disease , Humans , Nasal Polyps/drug therapy , Omalizumab/therapeutic use , Quality of Life , Retrospective Studies , Rhinitis/drug therapy , Treatment OutcomeABSTRACT
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Subject(s)
Humans , Female , Aged , Hyoid Bone/abnormalities , Vocal Cord Paralysis/etiology , Pharynx/physiopathology , Deglutition Disorders/etiology , Diagnosis, DifferentialSubject(s)
Branchial Region/abnormalities , Deglutition Disorders/etiology , Hyoid Bone/abnormalities , Ligaments/abnormalities , Neck Pain/etiology , Ossification, Heterotopic/etiology , Aged , Branchial Region/diagnostic imaging , Branchial Region/embryology , Female , Head Movements , Humans , Hyoid Bone/diagnostic imaging , Hyoid Bone/embryology , Ligaments/diagnostic imaging , Ligaments/embryology , Ossification, Heterotopic/diagnostic imaging , Paresthesia/etiology , Syndrome , Tomography, X-Ray ComputedABSTRACT
Several histopathological modalities of tumours can grow in the rhinopharynx. Solitary extramedullary plasmocytoma (SEP) is a low frequent variety of low-grade lymphoma. The aim of this work is to present a new case of SEP localized in rhinopharynx and to perform a review of diagnostic and therapeutic protocols of these neoplasias. They must be taken into account in the differential diagnosis of nasopharyngeal tumours.
Subject(s)
Nasopharyngeal Neoplasms , Plasmacytoma , Aged , Humans , Male , Nasopharyngeal Neoplasms/diagnosis , Nasopharyngeal Neoplasms/therapy , Plasmacytoma/diagnosis , Plasmacytoma/therapyABSTRACT
La nasofaringe es el asiento de tumores de muy variada naturaleza. El plasmocitoma solitario extramedular (PSE) es una variante poco frecuente de linfoma de bajo grado, cuya localización a este nivel es muy rara. El objetivo de este trabajo es presentar un nuevo caso de PSE localizado a nivel de la amígdala tubárica y revisar los protocolos diagnósticos y terapéuticos de este tipo infrecuente de neoplasias que deben tenerse en cuenta en el diagnóstico diferencial de los tumores de nasofaringe (AU)
Several histopathological modalities of tumours can grow in the rhinopharynx. Solitary extramedullary plasmocytoma (SEP) is a low frequent variety of low-grade lymphoma. The aim of this work is to present a new case of SEP localized in rhinopharynx and to perform a review of diagnostic and therapeutic protocols of these neoplasias. They must be taken into account in the differential diagnosis of nasopharyngeal tumours (AU)
Subject(s)
Humans , Male , Aged , Plasmacytoma/pathology , Nasopharyngeal Neoplasms/pathology , Diagnosis, DifferentialABSTRACT
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