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Rev. Asoc. Esp. Neuropsiquiatr ; 34(122): 375-382, abr.-jun. 2014.
Article in Spanish | IBECS | ID: ibc-121962

ABSTRACT

Introducción: La encefalitis límbica esuna enfermedad autoinmune y con frecuencia paraneoplásica,caracterizada por síntomas neuropsiquiátricosy asociada con frecuencia a diferentes tumorescomo el cáncer de células pequeñas de pulmón, timoma,teratoma testicular o cáncer de mama. Se hanidentificado varios autoanticuerpos, uno de los cualeses anti-NMDAR, asociado con más frecuencia a teratomaovárico y síntomas psiquiátricos en pacientesjóvenes. Caso clínico: Una paciente de 14 años conalucinaciones auditivas, problemas de lenguaje, agitación,movimientos anormales y pobre respuesta aantipsicóticos es finalmente diagnosticada de encefalitisanti-NMDAR, encontrando y tratando despuésen ella un teratoma ovárico. Discusión: La encefalitisanti-NMDAR es tratada con frecuencia primero porpsiquiatras por su presentación con cambios de personalidad,alucinaciones, agitación etc. Los psiquiatrasdeberíamos conocer esta enfermedad autoinmune paradar a los pacientes un correcto y temprano diagnósticoy tratamiento (AU)


Introduction: Limbic encephalitis isan autoimmune and often paraneoplastic disorder,characterized by neuropsychiatric symptoms andfrequently associated with several tumors such assmall cell lung cancer, thymoma, testicular teratomaor breast cancer. Several autoantibodies havebeen identified linked to limbic encephalitis, i.e.the anti-NMDAR, frequently associated with ovarianteratoma and psychiatric symptoms in youngpatients. Case report: A 14-year-old girl with auditoryhallucinations, speech problems, agitation,abnormal movements and poor response to antipsychoticswas diagnosed of anti-NMDAR encephalitis,and there after an ovarian teratoma wasdetected and treated. Discussion: Anti-NMDARencephalitis is often first treated by psychiatristsbecause of its presentation with personality changes,hallucinations, agitation etc. Psychiatristsshould consider this autoimmune disorder in orderto give patients correct and early diagnosis andtreatment (AU)


Subject(s)
Humans , Female , Adolescent , Limbic Encephalitis/complications , Limbic Encephalitis/diagnosis , Psychotic Disorders/complications , Psychotic Disorders/diagnosis , Teratoma/complications , Teratoma/psychology , Autoimmune Diseases/complications , Autoimmune Diseases/diagnosis , Language Disorders/complications , Limbic Encephalitis/physiopathology , Limbic Encephalitis/therapy , Hallucinations/complications , Hallucinations/diagnosis , Psychomotor Agitation/complications , Psychomotor Agitation/psychology , Affective Disorders, Psychotic/epidemiology , Affective Disorders, Psychotic/prevention & control , Immunotherapy/methods , Immunotherapy
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