[Short-term efficacy and safety of Brolucizumab for neovascular age-related macular degeneration in the Russian Federation]. / Kratkosrochnye dannye effektivnosti i bezopasnosti primeneniya preparata «Brolutsizumab¼ pri lechenii neovaskulyarnoi vozrastnoi makulyarnoi degeneratsii na territorii Rossiiskoi Federatsii.

PURPOSE: To analyze the short-term efficacy and safety of Brolucizumab in the treatment of patients with neovascular age-related macular degeneration (nAMD). MATERIAL AND METHODS: This retrospective pilot study included 154 patients (51 males and 103 females, mean age 73.9±8.1 years). Among the 154 patients, 97 (63.0%) had previously been treated with anti-VEGF drugs and were included in this study due to continuing disease activity. All study patients underwent standard ophthalmological examination and optical coherence tomography at the initial visit as well as at each monthly visit. RESULTS: A total of 283 Brolucizumab injections were performed in two ophthalmic care centers. In total, 49.4%, 24.0%, 20.1%, 6.5% of patients received 1, 2, 3 and 4 injections, respectively. Central retinal thickness has significantly decreased from 301±79 to 230±41 µm (p<0.05) in the ophthalmic center of the Military Medical Academy (site 1), and from 418±102 to 217±50 µm (p<0.05) in the ophthalmic center of the Institute of the Human Brain (site 2). The prevalence of subretinal and sub-RPE fluid has decreased statistically significantly (p<0.05) in patients of both sites. Visual acuity has not changed significantly (p>0.05) in patients of both sites. One case of mild vitreitis was registered, it was successfully treated with topical steroids. CONCLUSIONS: Both treatment-naive nAMD patients and those with the disease remaining active despite anti-VEGF therapy showed a significant decrease in disease activity. In this short-term study, the cumulative risk of intraocular inflammation associated with brolucizumab therapy amounted to 0.65%.

[A model of primary open-angle glaucoma: manifestations and outcomes].

OBJECTIVE: To determine the expected duration of the disease and the age of the patients with different stages ofprimary open-angle glaucoma complicated by pseudoexfoliation syndrome (PES) and/or patients with pseudoexfoliation glaucoma (PEG). METHODS: The study protocol included data from 120 patients (50 males (41.7%), 70 females (58.3%)); 189 eyes; 102 right eyes; 87 left eyes). The first study group (28 patients, 44 eyes) comprised patients with suspected glaucoma. The second group (53 patients, 84 eyes) consisted ofpatients with early glaucoma. The third group (21 patient, 33 eyes) included patients with advanced glaucoma, the forth group (18 patients, 28 eyes) comprised patients with terminal glaucoma. Mean age of the patients at diagnosis was 61.6 (58.4; 66.9) years and 66.9 (63.4; 72.8) years at the endpoint visit in 2013. In all cases, diagnosis was made in accordance with the differential diagnostics system and confirmed by special diagnostic techniques. The database included data from 3 qualified examinations taking account of the results of tonometry and static automated perimetry. RESULTS: The mean expected age of the patients age at the onset of blindness was 75.1 years. The occurrence of the event was limited to a period of 6.1 years. Mean age at the time of possible glaucoma development was 59.58 (56.14; 64.36) years. The disease itself could develop within 3.24 (-5.38; -1.2) years prior to diagnosis. CONCLUSION: Studies for glaucoma diagnosis should be focused on the age group of 55-60 years. The degree of IOP reduction in patients with advanced glaucoma does not agree with the Russian glaucoma society recommendations which accounts for progression of the disease.

[Disorders of cerebral hemodynamics in workers of ore mining and processing enterprise].

Using Doppler technologies, the authors studied blood flow in carotid and vertebral basillary systems of brain circulation, in orbital and central retinal arteries among workers of major occupations in ore mining and processing enterprise, who are subjected to occupational hazards complex. Workers with length of service over 20 years appeared to have stenosis and occlusion of medial cerebral artery and basillary artery.

[Evaluating microcirculation state in eye conjunctiva of machinery construction industry workers].

Studies of microcirculation vessels disorders in workers exposed to occupational physical hazards remain topical problem. The authors studied changes in microcirculatory vessels of conjunctiva, through biomicroscopy and calibrometric angiographic parameters in the examinees, and determined significant changes - narrowed arterioles, RBC aggreggation sites - in the workers with long length of service.

[The eye analyzer in machine-building industry workers according to electrophysiological indices].

To study visual analyzer electrophysiological changes in workers exposed to occupational physical factors remains to be a topical problem. The authors investigated retinal electrosensitivity and optic nerve electrolability and performed electroretinography in this group of workers, which determined significant retinal functional changes typical of retinal metabolic disturbances in workers having a long service.

[Antitoxic properties of hepazan--a novel inducer of microsomal enzyme system]. / Antitoksicheskie svoistva novogo induktora mikrosomal'noi fermentnoi sistemy gepazana.

The antitoxic properties of hepazan (dihydrothiazolexanthine), a new inductor of the microsomal enzyme system (MES) of liver were studied in white mice with the MES disorder induced by P. Aeruginosa toxin. It was found that hepazan not only eliminates the toxin-induced depression, but also decreases the toxic effects of ketoconazole, digoxin, and propranolol under the toxinemia conditions.