1.
Yao Xue Xue Bao
; 42(12): 1271-81, 2007 Dec.
Article
in Chinese
| MEDLINE
| ID: mdl-18338640
ABSTRACT
A novel inhibitor series for matrix metalloproteinases (MMPs) were designed and synthesized. Using succinate and malonate as zinc binding groups and long hydrophobic substituents to bind with S1' pockets, the compounds showed micromolar inhibition and selectivity for MMP-2 over others. And we found a better activity compound. It is a chance to find a better precursor of MMP-2 inhibitors with activity and bioavailability by further optimization of compounds.