ABSTRACT
A fully automated system for computer supported analysis of cardiovascular parameters on the basis of impedance technique, which is confined to the analysis of relative changes of stroke volume and cardiac output, has been developed and tested. The evaluation showed good agreement between automatic and manual calculation. As the whole computational procedure is done by software, which is written in a common language (BASIC), a maximum of flexibility and portability is guaranteed. Estimation of relative changes of stroke volume and cardiac output as well as peripheral blood flow is possible without any manual interaction. Extension from physiological measurement of healthy individuals to clinical application has been started.
Subject(s)
Cardiac Output , Cardiography, Impedance/methods , Diagnosis, Computer-Assisted/methods , Plethysmography, Impedance/methods , Programming Languages , Signal Processing, Computer-Assisted , Software Validation , Stroke Volume , Evaluation Studies as Topic , Humans , Microcomputers , Reproducibility of Results , Vascular ResistanceABSTRACT
In vitro studies were conducted into Psoroptes (Ps.) cuniculi larvae and nymphs of undefined age and gender. 30 males and females were involved in each of the experiments. Evidence was found the life expectancy of mites exposed to daily UV irradiation for 1, 2, 3, 4 or 5 minutes was reduced with significance, as compared to non-irradiated mites or to those with only one irradiation of the same length. Developmental stages of Ps. cuniculi responded in differentiated ways to the same dose rate, when applied by one single extended or fractionated shorter irradiation. Fractionated irradiation was more often survived by females than one single extended irradiation, whereas earlier death occurred to larvae following exposure to fractionated irradiation. Mange mites were not eliminated from rabbits with moderate ear mange by fractionated locally delimited in vivo irradiation, up to 16 applications of 10 minutes each or 6 or 9 applications of 10, 20 or 40 minutes each, with one-week intervals in between. Ear mange was clinically re-manifested, after irradiations had been discontinued.
Subject(s)
Mite Infestations/radiotherapy , Mites/radiation effects , Ultraviolet Rays , Animals , Chemical Fractionation , Female , Larva/radiation effects , Male , Nymph/radiation effects , RabbitsABSTRACT
Electrodes were implanted into the rat hippocampus in both hemispheres for increasing periods of up to 60 days, and the effects of trauma and electrical stimulation of enzymes controlling cell metabolism in the region of implantation were examined and assessed in relation to studies on humans. In the unstimulated hippocampus as a control, enzyme changes were mainly confined to a narrow area of tissue damage surrounding the electrode. The enzyme changes in response to trauma varied widely; some enzymes controlling tissue respiration showed early and rapid changes, increasing in hyperactive, swollen glial cells and vascular endothelium and decreasing in nerve cells and neuropile. Acid phosphatase activity also increased rapidly in glial cells; other phosphate-releasing enzymes increased more gradually with time. A turning point in these chages was apparent between 25 and 40 days, followed by a reversion to more normal levels at 60 days. Electrical stimulation of the hippocampus in the contralateral hemisphere produced no detectable enzyme changes from those of the unstimulated hippocampus.
