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Basic Clin Pharmacol Toxicol ; 115(5): 417-22, 2014 Nov.
Article in English | MEDLINE | ID: mdl-24690162

ABSTRACT

In this study, we leveraged on complete nationwide prescription data for the total adult population in Iceland (N = 227,000) to examine how attention-deficit/hyperactivity disorder (ADHD) drugs have been used over the past decade. In particular, we aimed to describe the prevalence, incidence and duration of use of stimulants and atomoxetine, among adults (≥19 years) in Iceland, with regard to sex, age, type of drug and specialty of the prescribing physician. Our results indicate that the 1-year period prevalence of ADHD drug use rose, from 2.9 to 12.2 per 1000 adults between 2003 and 2012, with the most pronounced increases among young adults (19-24 years). The annual incidence increased 3 times, similarly among men and women. Extended-release methylphenidate formulations were the most commonly used ADHD drugs. Specialists in psychiatry initiated treatment in 79% of new adult ADHD drug users. The proportion of users still receiving treatment after 1 year varied from 43.0% (19-24 years), 57.2% (25-49 years) to 47.5% (50+ years). After 3 years, the corresponding proportions still on treatment were 12.4%, 24.5% and 24.3%, and after 5 years 7.9%, 15.9% and 16.8%. These results of increasing ADHD drug use and short treatment durations call for further investigation of the quality of treatment regimens for adults with ADHD and better follow-up of patients treated with ADHD drugs.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Central Nervous System Stimulants/therapeutic use , Practice Patterns, Physicians'/statistics & numerical data , Propylamines/therapeutic use , Adult , Age Factors , Atomoxetine Hydrochloride , Central Nervous System Stimulants/administration & dosage , Female , Humans , Iceland , Male , Methylphenidate/administration & dosage , Methylphenidate/therapeutic use , Middle Aged , Practice Patterns, Physicians'/trends , Prevalence , Propylamines/administration & dosage , Time Factors , Young Adult
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