ABSTRACT
BACKGROUND: The present study aims to evaluate the influence of alveolar recruitment strategy (ARS) and positive end-expiratory pressure (PEEP) combined with autoflow on respiratory mechanics, the oxygen index (OI), pulmonary shut [Qs/Qt(%)], and the concentrations of IL-6 and TNF-α in venous blood after surgery in obese patients who experienced thoracic surgery with one-lung ventilation (OLV). METHODS: A total of 36 obese patients with ASAII-III degree, who experienced selective pulmonary lobectomy, were within 36-74 years old, and had a BMI of 30-40 kg/m2, were randomly divided into two groups: control group (C group) and protective ventilation group (P group). In the P group, ARS was given once when OLV began. Then, ventilation at 7 mmHg of PEEP and autoflow were given. The Ppeak before OLV (T1), at 30 minutes after OLV (T2), and at the 5 minutes after two-lung ventilation (TLV) (T3), and the changes of Pplat and Cdyn were recorded. Then, arteriovenous blood was drawn at T1, T2, T3 and T4 (6 hours after the operation), blood-gas indicators, including SPO2, PaCO2 and PaO2, were measured, and the value of Qs/Qt(%) was calculated. Afterwards, venous blood was collected at T1 and T5 (18 hours after surgery), and the concentrations of IL-6 and TNF-α were detected. The clinical pulmonary infection score (CPIS) was determined at the first day and seventh day after the operation. RESULTS: In both groups, Cdyn and OI decreased, while Pplat, Ppeak and Qs/Qt(%) increased (P<0.05) at T2, when compared with those at T1. At T2 and T3, Pplat and Ppeak decreased (P<0.05) in the P group, when compared with the C group. At T2, T3 and T4, OI increased (P<0.05) in the P group, when compared with the C group. At T2, T3 and T4, PaCO2 and Qs/Qt(%) decreased in the P group, when compared with the C group. The concentrations of IL-6 and TNF-α decreased in the P group, when compared with the C group. CONCLUSIONS: The ventilation model of ARS and PEEP combined with autoflow can better reduce airway pressure and the production of injurious inflammatory cytokines in blood in obese patients. Furthermore, it can reduce Qs/Qt during and at 6 hours after thoracotomy, improve OI and maintain the acid-base balance of the internal environment, which may be applied in clinical work. This brings new enlightenment and needs to be clarified through further studies.
ABSTRACT
OBJECTIVE: To compare the effectiveness of lung isolation among double-lumen endotracheal tube, Univent blocker and bronchial blocker during thoracic surgical anesthesia. METHODS: A total of 120 patients undergoing elective thoracic surgery were enrolled. They were intubated with Mallinckrodt DLT (DLT group, n = 40), Univent blocker (UNI group, n = 40) and Coopdech bronchial blocker (BB group, n = 40) after intravenous anesthesia induction. The following parameters were recorded:(1) time to initially position the assigned tube; (2) changes of mean arterial pressure (MAP) and heart rate (HR) at 5 min post-intubation; (3) lung collapse scores; (4) frequency of malpositions; (5) airway press and blood gas change during one lung ventilation (OLV); (6)postoperative sore throat at 24 h postoperation. RESULTS: No statistical difference existed in positioning three types of endotracheal tubes. But MAP and HR were higher at post-intubation in DLT group compared with the other 2 groups. No difference existed among the lung isolation devices in lung collapse scores at 5/10 min after pleural opening. As compared with the UNI and BB groups, Ppeak and Pplat increased while compliance decreased in DLT group during OLV. Statistical differences existed in tube malpositions among three groups (n = 4, DLT; n = 5, UNI; n = 8, BB). The incidence of postoperative sore throat was significantly higher in DLT group (70%) than the other two groups (37.5%, UNI; 22.5%, BB). CONCLUSION: As compared with DLT, Univent and Coopdech bronchial blocker may reduce the airway injury and improve the compliance during OLV. But there is a higher intraoperative incidence of tube malposition.