ABSTRACT
The aim of the present study was to develop the first life tables for the dog population of the Autonomous City of Buenos Aires by constructing life expectancy tables. Data on canines received for final disposal at the Luis Pasteur Zoonosis Institute of the Autonomous City of Buenos Aires from January 2018 to December 2021 were used to prepare the life tables. Of the 11,429 dogs that died in that period, the overall life expectancy at birth was 11.88 years (95% CI = 11.37-12.39). There was no difference in life expectancy at birth by sex or by pure versus cross breeds. According to neuter status, life expectancy at birth in neutered (13.98 years) was significantly higher than in entire (11.46 years) (p-value = 0.00001). Life tables varied according to the breed studied, with the Pekingese having the highest life expectancy at birth 16.42 years (95% CI: 15.87-16.98), and the Pit bull having the lowest life expectancy at birth 10.13 years (95% CI: 9.58-10.68). The current study provides useful information for veterinary professionals and pet owners and is a valuable tool for planning and developing effective health policies.
Subject(s)
Life Expectancy , Animals , Dogs , Argentina/epidemiology , Male , Female , Life TablesABSTRACT
En los últimos años la positividad en el diagnóstico de rabia en quirópteros de la Ciudad de Buenos Aires se duplicó, pasando de 2.33% promedio entre 2014-2017, a 4,68% promedio del 2018 al 2021.En este Informe se analiza el comportamiento temporal de rabia en murciélagos de esta ciudad para proporcionar un pronóstico de positividad esperada para los próximos meses.
Subject(s)
Humans , Animals , Rabies/diagnosis , Rabies/prevention & control , Rabies/epidemiology , Chiroptera/immunology , Epidemiological Monitoring/veterinary , Viral Zoonoses/prevention & control , EpidemiologyABSTRACT
El objetivo del presente informe es exponer la situación actual de la vacunación antirrábica de la Ciudad de Buenos Aires, con el fin de realizar una planificación estratégica de prevención y control de la enfermedad. Se utilizaron datos sobre vacunación realizada por veterinarias privadas estimados a partir de la venta de talonarios por parte del Consejo Profesional de Médicos Veterinarios (CPMV); así como la vacunación realizada por los efectores públicos de salud: Instituto de Zoonosis Luis Pasteur (IZLP) y Mascotas de la Ciudad (MC).
Subject(s)
Rabies/prevention & control , Rabies/epidemiology , Rabies Vaccines/administration & dosage , Rabies Vaccines/supply & distribution , Immunization Programs/supply & distribution , Immunization Programs/statistics & numerical dataABSTRACT
The present study aimed to evaluate the impact caused by the 2016 World Health Organization (WHO) diagnostic classification of gliomas in 139 patients studied in Argentina. Formalin-fixed paraffin-embedded tissues were used for histological and immunohistochemical analysis [glial fibrillary acidic protein, KI67, synaptophysin and isocitrate dehydrogenase (IDH)1-R132H]. DNA from formalin-fixed paraffin-embedded tissues was used for molecular analysis: 1p/19q co-deletion and mutation status of the IDH gene. These experiments were performed by direct Sanger sequencing and multiplex ligation-dependent probe amplification. According to the new classification, diagnoses included oligodendroglioma IDH-mutant and 1p/19q co-deletion (4.20%), anaplastic oligodendroglioma IDH-mutant and 1p/19q co-deletion (2.52%), diffuse astrocytoma IDH-mutant (6.72%), diffuse astrocytoma IDH-wild type (1.68%), anaplastic astrocytoma IDH-mutant (5.04%), anaplastic astrocytoma IDH-wild type (8.40%), glioblastoma IDH-mutant (5.88%) and glioblastoma IDH-wild type (65.56%). Regarding tumor histology, 60% of oligodendrogliomas, 35% of astrocytoma and 100% of unclassified gliomas were re-classified, while glioblastomas maintained their initial classification. Additionally, the present study evaluated the prognostic value of the histological grade for the 2007 and 2016 WHO classifications of gliomas. The histological subgroup associated with longer overall survival (OS) was grade II glioma (OS-2007WHO, 35.6 months; and OS-2016WHO, 47.7 months). Glioblastoma was the subgroup associated with a poor outcome (OS-2007WHO, 10.4 months; and OS-2016WHO, 11.1 months). The present study evaluated the OS of tumor grade subgroups with respect to their IDH status. For all subgroups, IDH-mutant tumors were associated with an improved prognosis compared with IDH-wild type tumors. The results suggested that the incorporation of molecular biomarkers in the new WHO classification improves tumor characterization and prognostic value of the subgroups.
ABSTRACT
El aislamiento social, preventivo y obligatorio (ASPO) es una medida excepcional que el Gobierno Nacional adopta en un contexto crítico. Con el fin de proteger la salud pública frente a la propagación de la Covid-19, se dispuso que todas las personas que habitan, o se encuentren temporalmente, en las jurisdicciones donde rige esta normativa deberán permanecer en sus domicilios habituales, sólo pudiendo realizar desplazamientos mínimos e indispensables para aprovisionarse de artículos de limpieza, medicamentos y alimentos (Decreto Nacional 297/2020). En la Ciudad de Autónoma de Buenos Aires (CABA) rige desde el 20 de marzo el ASPO, y se ha ido flexibilizando a lo largo del tiempo. En este contexto se modificaron conductas, actividades e incluso asistencia a los centros de salud para consultas no relacionadas con Covid-19. En este informe pretendemos dar cuenta de la situación en relación a la denuncia de accidentes por mordeduras de animales de compañía. (AU)
Subject(s)
Humans , Animals , Male , Female , Cats , Dogs , Rabies/prevention & control , Social Isolation , Bites and Stings/prevention & control , Bites and Stings/veterinary , Bites and Stings/epidemiology , Accidents, Home/statistics & numerical data , Pets , Animals, DomesticABSTRACT
BACKGROUND: Development of rapid diagnostic tests for tuberculosis is a global priority. A whole proteome screen identified Mycobacterium tuberculosis antigens associated with serological responses in tuberculosis patients. We used World Health Organization (WHO) target product profile (TPP) criteria for a detection test and triage test to evaluate these antigens. METHODS: Consecutive patients presenting to microscopy centers and district hospitals in Peru and to outpatient clinics at a tuberculosis reference center in Vietnam were recruited. We tested blood samples from 755 HIV-uninfected adults with presumptive pulmonary tuberculosis to measure IgG antibody responses to 57 M. tuberculosis antigens using a field-based multiplexed serological assay and a 132-antigen bead-based reference assay. We evaluated single antigen performance and models of all possible 3-antigen combinations and multiantigen combinations. RESULTS: Three-antigen and multiantigen models performed similarly and were superior to single antigens. With specificity set at 90% for a detection test, the best sensitivity of a 3-antigen model was 35% (95% confidence interval [CI], 31-40). With sensitivity set at 85% for a triage test, the specificity of the best 3-antigen model was 34% (95% CI, 29-40). The reference assay also did not meet study targets. Antigen performance differed significantly between the study sites for 7/22 of the best-performing antigens. CONCLUSIONS: Although M. tuberculosis antigens were recognized by the IgG response during tuberculosis, no single antigen or multiantigen set performance approached WHO TPP criteria for clinical utility among HIV-uninfected adults with presumed tuberculosis in high-volume, urban settings in tuberculosis-endemic countries.
Subject(s)
Antigens, Bacterial/immunology , Immunoglobulin G/immunology , Mycobacterium tuberculosis/immunology , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/immunology , Adolescent , Adult , Female , Humans , Immunoglobulin G/blood , Male , Middle Aged , Peru , Reproducibility of Results , Serologic Tests/methods , Serologic Tests/standards , Tuberculosis, Pulmonary/epidemiology , Young AdultABSTRACT
In Argentina, data on the presence of members of the genus Bartonella is scarce. To increase knowledge about these zoonotic pathogens in this country, the presence and variability of Bartonella spp. was investigated in cats and dogs from Buenos Aires. Bartonella spp. was detected in 17.8% of cats, while all dogs tested negative by PCR and Reverse Line Blot. B. henselae was the most frequent species, being detected in 11.9% (14/101), while B. clarridgeiae was found in only 5.9% (6/101) of the cats. Afterwards, B. henselae isolates and positive blood samples were characterized by Multiple Locus Sequence Typing (MLST) and Multiple Locus Variable Number Tandem Repeats Analysis (MLVA). As result, four different MLST sequence types (ST) and eight MLVA profiles were identified. ST 1 was the most frequent variant found in cats, followed by ST 8. Interestingly, some of the MLVA profiles that were detected in this study have been previously associated with human disease, and represents a potential risk of infection. Veterinarians and physicians should consider the presence of these emerging pathogens in their diagnostic routine.
Subject(s)
Bartonella Infections/veterinary , Bartonella/classification , Bartonella/genetics , Cat Diseases/microbiology , Animals , Argentina , Bartonella Infections/microbiology , Cats , Dogs , Minisatellite Repeats , Multilocus Sequence Typing , Polymerase Chain Reaction/veterinaryABSTRACT
Intestinal metastases from lung cancer are exceptional and even more rare is their manifestation before the primary tumor. The clinical manifestation may require surgical resection because of intestinal perforation, hemorrhage, intestinal obstruction or partial blockage as in the case that we report. Survival in the few cases reported, is low and generally does not exceed 20 weeks, regardless of the treatment performed. We report the case of a jejuno-jejunal intussusception manifested by occlusive syndrome and gastrointestinal bleeding due to the metastasis of an adenosquamous lung carcinoma.