ABSTRACT
The review provides information about the features of the sensitivity of thymocytes, lymphoid organs' cells and T-lymphocytes of peripheral blood to the hormones secreted by anterior pituitary gland's cells: growth hormone, thyrotropin, adrenocorticotropic hormone, prolactin and ß-endorphin. Some aspects of the T-lymphocytes's response to humoral signals from the hypophysis are shown in the article. Also the pituitary hormones' role in the regulation of proliferation, differentiation, and cytokine production of T-lymphocytes in normal and pathological conditions of the organism being discussed.
Subject(s)
Adrenocorticotropic Hormone/pharmacology , Growth Hormone/pharmacology , Pituitary Gland, Anterior/metabolism , Prolactin/pharmacology , Thymocytes/drug effects , Thyrotropin/pharmacology , beta-Endorphin/pharmacology , Adrenocorticotropic Hormone/genetics , Adrenocorticotropic Hormone/immunology , Animals , Cell Differentiation/drug effects , Cell Proliferation/drug effects , Gene Expression Regulation , Growth Hormone/genetics , Growth Hormone/immunology , Humans , Leukocytes, Mononuclear/cytology , Leukocytes, Mononuclear/drug effects , Leukocytes, Mononuclear/immunology , Primary Cell Culture , Prolactin/genetics , Prolactin/immunology , Signal Transduction , Thymocytes/cytology , Thymocytes/immunology , Thyrotropin/genetics , Thyrotropin/immunology , beta-Endorphin/genetics , beta-Endorphin/immunologyABSTRACT
Total RNA from the bone marrow of healthy donor rats was injected to experimental rats 6 h, 2 h, or 30 min prior to a single γ-irradiation in the sublethal dose of 6 Gy. Injection total RNA 30 min prior to the exposure most effectively restored erythropoiesis in experimental animals. In 5 days, reticulocyte count in these animals 30-fold surpassed the control (injection of 0.9% NaCl). In 12 days, the content of new erythroblastic islands in the bone marrow in rats injected with the total RNA 2 h or 30 min prior to irradiation increased significantly and erythropoiesis recovery activation was observed.
Subject(s)
Erythropoiesis/drug effects , RNA/administration & dosage , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/administration & dosage , Animals , Animals, Outbred Strains , Bone Marrow Cells/drug effects , Bone Marrow Cells/physiology , Drug Evaluation, Preclinical , Erythropoiesis/radiation effects , Gamma Rays , Male , Radiation Injuries, Experimental/blood , RatsABSTRACT
The review presents facts telling about the involvement of RNA of lymphocytes into regulation of proliferation and differentiation of cells in various tissues. There are considered: transport mechanisms of exogenous RNAs in cells, the role of non-coding RNAs molecules in the regulation of embryonic and postnatal morphogenesis. The long non-coding RNAs and microRNAs of T-lymphocytes are characterized, also there is made a comparative analysis of different microR-NAs expression in T cells and the regulatory effects of these molecules in reparative processes. There are described the RNA technologies, stimulating the anti-tumor immunity and regeneration of damaged tissues used in clinical practice, and also the perspectives of creating new treatments based on the use of RNA preparations.
Subject(s)
Cell Communication/physiology , Cell Differentiation/physiology , Cell Proliferation/physiology , Lymphocytes/metabolism , RNA, Untranslated/metabolism , Regeneration/physiology , Animals , Humans , Lymphocytes/cytologyABSTRACT
Lympnoici regulation, in aciaition to ensuring tne protection of tne antigen, is aimecl at maintaining a qualitative, quantitative, structural and functional integrity of the body. T-lymphocytes and growth factors are involved in cell proliferation, differentiation, and tissue and organ regeneration. Lymphocyte's, sensitivity to homeostasis changes and their morphogenetic function are connected with a large number of receptors to bioactive substances and with their ability to syn- thesize and secrete hormones and tissue growth factors. At the same time tissue growth factors are involved in the development of thymocytes, in the differentiation of T helper and cytotoxic lymphocytes. Growth factors modulate the functions of Thl, Th2, Treg, Thl7, Th9. The important aspects of the interaction of T cells and EGF, TGF-P, FGF, VEGF, PlGF, HGF/SF in normal and pathological conditions are shown in this review.
Subject(s)
Intercellular Signaling Peptides and Proteins/metabolism , T-Lymphocytes/metabolism , Animals , Humans , Intercellular Signaling Peptides and Proteins/genetics , T-Lymphocytes/cytology , T-Lymphocytes/physiologyABSTRACT
Total RNA, isolated from rat spleen's lymphoid cells during the period of hematopoietic tissue's reparative regeneration, has a remarkable activating effect on the processes of erythroblastic islet formation in vivo and in vitro. Total RNA, isolated from normal rat spleen's lymphoid cells, restores depressed erythropoiesis in erythroblastic islets up to physiological level.
