Dengue fever outbreaks in Eritrea, 2005-2015: A case for strengthening surveillance, control and reporting.

BACKGROUND: The geographic distribution and burden of dengue is increasing globally. This study aims to evaluate dengue outbreaks and to substantiate the need for strengthened surveillance, reporting and control in Eritrea. METHODS: Data from two cross-sectional dengue epidemic investigations in 2005 and 2010 were analyzed. Samples were tested for dengue virus-specific IgM and IgG antibodies using capture enzyme-linked immunosorbent assays. Dengue vectors' breeding attributes were characterized and epidemic risk indices determined. National routine surveillance weekly reports from 2005 to the second quarter of 2015 were analyzed for spatiotemporal trends. RESULTS: Dengue outbreaks increased in Eritrea from 2005 to 2015 with clinical presentation varying markedly among patients. The house and container indices for Aedes aegypti were 40 and 39.6 % respectively, with containers having A. aeqypti varying significantly (P < 0.04). Serum from 33.3 % (n = 15) and 88 % (n = 26) of clinical dengue cases in Aroget sub-Zoba (district) of Gash Barka Zoba (region) contained anti-DENV IgM antibody in 2005 and 2006, respectively. The national surveillance data from 2005 to 2015 indicate an overall spatiotemporal increase of dengue fever. CONCLUSIONS: The increase in dengue outbreaks has been confirmed in Eritrea and necessitates strengthening of surveillance and health worker and laboratory capacity, as well as targeted vector control interventions.

Underestimation of prevalence of raised blood sugar from history compared to biochemical estimation: support for the WHO rule of halves in a population based survey in Eritrea of 2009.

To ascertain the prevalence of diabetes mellitus from history and biochemical estimation so as to attest the WHO Rule of halves in a lean population. A population based national survey on diabetes mellitus was carried out in 2009. History and fingerpicks blood analysis were examined according to recommended procedures of the WHO STEPwise approach and the WHO recommended automated machine to compare the two modalities of estimating diabetes prevalence. Over 6000 people with a response rate of 95 % and a prevalence of raised blood glucose of 5.0 %. The prevalence from history of raised blood sugar was 2.2 %. Less than half (47 %) of the persons with high blood glucose were aware of their status with less than half on treatment. Of those on treatment less than half (30 %) were well controlled. Prevalence of raised fasting blood glucose was more than double that estimated from history, with less than half of the people aware of their status and of those on treatment nearly half are under good control. The underestimation of the disease through history supports the WHO rule of halves and calls for the use of biochemical tests when estimating prevalence of diabetes in the general population or at least doubling the rate from history alone.

Consolidating strategic planning and operational frameworks for integrated vector management in Eritrea.

BACKGROUND: Contemporary malaria vector control relies on the use of insecticide-based, indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs). However, malaria-endemic countries, including Eritrea, have struggled to effectively deploy these tools due technical and operational challenges, including the selection of insecticide resistance in malaria vectors. This manuscript outlines the processes undertaken in consolidating strategic planning and operational frameworks for vector control to expedite malaria elimination in Eritrea. CASE DESCRIPTION: The effort to strengthen strategic frameworks for vector control in Eritrea was the 'case' for this study. The integrated vector management (IVM) strategy was developed in 2010 but was not well executed, resulting in a rise in malaria transmission, prompting a process to redefine and relaunch the IVM strategy with integration of other vector borne diseases (VBDs) as the focus. The information sources for this study included all available data and accessible archived documentary records on malaria vector control in Eritrea. Structured literature searches of published, peer-reviewed sources using online, scientific, bibliographic databases, Google Scholar, PubMed and WHO, and a combination of search terms were utilized to gather data. The literature was reviewed and adapted to the local context and translated into the consolidated strategic framework. DISCUSSION: In Eritrea, communities are grappling with the challenge of VBDs posing public health concerns, including malaria. The global fund financed the scale-up of IRS and LLIN programmes in 2014. Eritrea is transitioning towards malaria elimination and strategic frameworks for vector control have been consolidated by: developing an integrated vector management (IVM) strategy (2015-2019); updating IRS and larval source management (LSM) guidelines; developing training manuals for IRS and LSM; training of national staff in malaria entomology and vector control, including insecticide resistance monitoring techniques; initiating the global plan for insecticide resistance management; conducting needs' assessments and developing standard operating procedure for insectaries; developing a guidance document on malaria vector control based on eco-epidemiological strata, a vector surveillance plan and harmonized mapping, data collection and reporting tools. CONCLUSION: Eritrea has successfully consolidated strategic frameworks for vector control. Rational decision-making remains critical to ensure that the interventions are effective and their choice is evidence-based, and to optimize the use of resources for vector control. Implementation of effective IVM requires proper collaboration and coordination, consistent technical and financial capacity and support to offer greater benefits.

Results of a rapid assessment of avoidable blindness (RAAB) in Eritrea.

PURPOSE: To collect baseline data for planning of the National Blindness Prevention & Control Program and for monitoring future achievements. METHODS: Sixty six clusters of 50 people were selected from a sampling frame that included all 2,593 villages in Eritrea (population 3.56 million). Within each selected village, 50 eligible people aged 50+ years were selected. All eligible participants underwent visual acuity (VA) measurement followed by examination by an ophthalmologist if the presenting VA (PVA) was less than 6/18. RESULTS: Three thousand one hundred sixty three of the 3300 eligible persons were examined (coverage 95.9%). The adjusted prevalence of blindness (PVA < 3/60 in the better eye) in the survey population was 7.5% (95% confidence interval [CI]: 6.2-8.8%), bilateral severe visual impairment (PVA < 6/60 to ≥ 3/60 in the better eye) 3.0% (95% CI: 2.3-3.7%) and of bilateral moderate visual impairment (PVA < 6/18 to ≥ 6/60 in the better eye) 10.5% (95% CI: 9.1-11.9%). Of all bilateral blindness 55% was due to cataract. The adjusted cataract surgical coverage (percentage of people requiring cataract surgery that have had surgery) was 68% for blind people and 41% for blind eyes. Cataract surgery outcome was poor (PVA < 6/60) in 39% of all eyes operated in the past. CONCLUSIONS: The prevalence of blindness was high compared to recent surveys in Africa. Visual outcome after cataract surgery potentially could be improved by more detailed pre-operative examination, coaching of surgeons, and provision of adequate optical correction, including routine monitoring of visual outcome after cataract surgery. The development of intervention programs for refractive error and glaucoma should be considered.

Prevalence of tobacco use in Eritrea: results from a noncommunicable disease risk factor survey.

The prevalence of noncommunicable diseases in Eritrea is increasing. Tobacco use is a recognized risk factor for most of these diseases, especially cardiovascular disease. No data have been published on tobacco use in Eritrea. The present study sought to establish the prevalence of tobacco smoking in Eritrea. The World Health Organization STEPwise approach was used for the survey, conducted in 2004 on a random national sample size of 2,460 subjects (response rate = 93.7%). The prevalence of tobacco smoking in the general population was 8.1%; the prevalence was 15% among men, compared with 0.6% among women. Prevalence rates were higher in those older than 45 years of age. The prevalence of tobacco smoking was higher among Muslims (11.4%) than Orthodox Christians (5.8%), and among alcohol drinkers (10.2%) than nondrinkers (6.6%). The majority of tobacco users (89.3%) used commercially available cigarettes. A study on knowledge, attitudes, and practices regarding tobacco use is needed to determine the behavioral factors leading to tobacco smoking among the vulnerable groups.

Roll back malaria--an African success story in Eritrea.

BACKGROUND: High morbidity and mortality from malaria in Africa prompted the Abuja Declaration by African Heads of State in 2000. The goal set in the declaration for 2010 was to reduce malaria mortality by 50%. Countries were therefore expected to ensure that 60% of people suffering from malaria had access to treatment, that 60% of those at risk received intermittent prophylaxis, and that 60% of people in high-risk groups were using insecticide-treated nets (ITNs) by 2005. In 1999 Eritrea introduced malaria policies, strategies and multi-level interventions targeting households, communities and health facilities. OBJECTIVES: To assess Eritrea's progress towards meeting the Abuja Declaration goal, targets and key determinants. METHODS: A retrospective study was undertaken using data from the Health Management Information System (HMIS) and reports of annual reviews. Correlation and regression analysis were used to assess associations between selected variables. RESULTS: The incidence rate for malaria decreased from 6000/100000 in 1998 to 1100/100000 in 2003, representing > 80% decline in morbidity. The cumulative number of ITNs distributed increased from 50000 in 1998 to 685000 in 2003. The ITN impregnation rate increased from 15% to > 70% during the same period. Indoor residual spraying increased from 7444 kg to 41157 kg of insecticide in 2004 resulting in the protected population increasing from 117017 to 244315 respectively. The number of health workers recruited and trained rose from 936 to 4118. There was a strong correlation between the malaria incidence rate, distribution of ITNs (R2 = 0.76) and the total number of health workers trained (R2 = 0.72). The association was consistent in regression analysis (beta = -0.05, p = 0.03 for ITNs, and beta = -0.249, p = 0.05 for trained health workers). CONCLUSION: Within 5 years Eritrea met the Abuja Declaration objectives through multiple vector-control methods, case management and surveillance.

A steep decline of malaria morbidity and mortality trends in Eritrea between 2000 and 2004: the effect of combination of control methods.

BACKGROUND: Malaria is a huge public health problem in Africa that is responsible for more than one million deaths annually. In line with the Roll Back Malaria initiative and the Abuja Declaration, Eritrea and other African countries have intensified their fight against malaria. This study examines the impact of Eritrea's Roll Back Malaria Programme: 2000-2004 and the effects and possible interactions between the public health interventions in use. METHODS: This study employed cross-sectional survey to collect data from households, community and health facilities on coverage and usage of Insecticide-Treated Nets (ITNs), Indoor Residual Spraying (IRS), larvicidal activities and malaria case management. Comparative data was obtained from a similar survey carried out in 2001. Data from the Health Management Information System (HMIS) and reports of the annual assessments by the National Malaria Control Programme was used to assess impact. Time series model (ARIMA) was used to assess association. RESULTS: In the period 2000-2004, approximately 874,000 ITNs were distributed and 13,109 health workers and community health agents were trained on malaria case management. In 2004, approximately 81% households owned at least one net, of which 73% were ITNs and 58.6% of children 0-5 years slept under a net. The proportion of malaria cases managed by community health agents rose from 50% in 1999 to 78% in 2004. IRS coverage increased with the combined amount of DDT and Malathion used rising from 6,444 kg, in 2000 to 43,491 kg, in 2004, increasing the population protected from 117,017 to 259,420. Drug resistance necessitated regimen change to chloroquine plus sulfadoxine-pyrimethamine. During the period, there was a steep decline in malaria morbidity and case fatality by 84% and 40% respectively. Malaria morbidity was strongly correlated to the numbers of ITNs distributed (beta = -0.125, p < 0.005) and the amount (kg) of DDT and Malathion used for IRS (beta = -2.352, p < 0.05). The correlation between malaria case fatality and ITNs, IRS, population protected and annual rainfall was not statistically significant. CONCLUSION: Eritrea has within 5 years attained key Roll Back Malaria targets. ITNs and IRS contributed most to reducing malaria morbidity.

Prevalence of non-communicable disease risk factors in Eritrea.

OBJECTIVE: To establish the baseline prevalence rates for non-communicable disease risk factors in Eritrea. STUDY DESIGN: A cross-sectional survey was conducted among all the ethnic groups in Eritrea with the WHO STEPwise approach. Hypertension was defined as blood pressure > or = 140/90 mm Hg or a person on medication for hypertension, while diabetes based on medical history of the disease. Of the targeted sample size of 2460, 2352 responded. Respondents were distributed among the six regions of the country proportional to population size. A multistage cluster sampling technique was used. Males and females from 15 to 64 years of age were studied. MAIN OUTCOME MEASURES: Prevalence rates of hypertension, diabetes mellitus, obesity, smoking, alcohol consumption, physical inactivity, and low vegetable and low fruit consumption. RESULTS: Prevalence rate of daily smoking of 7.2% with variations among age, sex, religion and regions. A high prevalence of low fruit and low vegetable intake was observed at 84.7% and 50.6% respectively. Alcohol drinking was 39.6%. Level of physical activity was high (90%). The prevalence of obesity was low at 3.3%. The prevalence of hypertension in the general population was 16%, while 2.2% were known diabetic patients. More than 80% of the hypertensive persons were not aware of their condition. No significant rural/urban or sex difference was seen in hypertension prevalence. CONCLUSION: The baseline data are useful for developing interventions designed to prevent and control NCDs in Eritrea.