ABSTRACT
Objectives: In a context of COVID-19 vaccine shortages, this study sought to evaluate the safety and efficacy of receiving one dose of Gam-COVID-Vac rAd26 followed by a second COVID-19 vaccine dose of either Gam-COVID-Vac rAd5, ChAdOx1 nCoV-19 or BBIBP-CorV in a cohort of older adults. Study design: Single-centre, randomised, open label, non-inferiority trial. Methods: Adults aged ≥65 years who had received one dose of Gam-COVID-Vac rAd26 were randomised in a 1:1:1 ratio to receive a second-dose COVID-19 vaccination of either Gam-COVID-Vac rAd5, ChAdOx1 nCoV-19 or BBIBP-CorV. The primary outcome was the assessment of the humoral immune response to vaccination (i.e. antibody titres of SARS-CoV-2 spike protein at 28 days after second-dose vaccination). In addition, neutralising antibody titres at day 28 for the three schedules were measured. Results: Of 85 participants who were enrolled in the study between 26 and July 30, 2021, 31 individuals were randomised to receive Gam-COVID-Vac rAd5, 27 to ChAdOx1 nCoV-19 and 27 to BBIBP-CorV. The mean age of participants was 68.2 years (SD 2.9) and 49 (57.6%) were female. Participants who received Gam-COVID-Vac rAd5 and ChAdOx1 nCoV1-19 showed significantly increased anti-S titres at 28 days after second-dose vaccination, but this magnitude of difference was not observed for those who received BBIBP-CorV. The ratio between the geometric mean at day 28 and baseline within each group was 11.8 (6.98-19.89) among patients assigned to Gam-COVID-Vac rAd26/rAd5, 4.81 (2.14-10.81) for the rAd26/ChAdOx1 nCoV-19 group and 1.53 (0.74-3.20) for the rAd26/BBIBP-CorV group. All of the schedules were shown to be safe. Conclusions: The findings in this study contribute to the scarce information published on the safety and immunogenicity of Gam-COVID-Vac heterologous regimens and will help the development of guidelines and vaccine programme management.
ABSTRACT
Los resultados de la Encuesta Nacional de Nutrición y Salud 2004/2005 advirtieron que hay situaciones de inadecuación nutricional en todas las clases sociales. Tanto la promoción de la salud como la prevención y el tratamiento de estos problemas nutricionales son temas de salud pública. La Educación Alimentaria y Nutricional (EAN) es una herramienta efectiva y accesible como parte de programas promotores de salud orientados al desarrollo de prácticas alimentarias saludables. Se realizó un estudio longitudinal de tipo experimental, durante el período escolar marzo a diciembre de 2007, con 279 niños de 9 a 13 años de edad, de 5 colegios privados, de doble escolaridad, mixtos, de Zona Norte del Gran Buenos Aires y Capital Federal, que participaron de una intervención de EAN de un mes de duración. Se trabajó en cada oportunidad con grupos de aproximadamente 30 alumnos. El objetivo de esta intervención es determinar si la metodología de EAN aplicada es efectiva para la modificación de conocimientos, como un primer paso al acercamiento de estilos de vida.