ABSTRACT
Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. We report two cases with stage IV breast cancer, aged 66 and 71 years, who developed sclerodermic skin lesions in their extremities after starting treatment with placlitaxel and nabplaclitaxel respectively.
Subject(s)
Antineoplastic Agents , Breast Neoplasms , Scleroderma, Systemic , Antineoplastic Agents/adverse effects , Breast Neoplasms/drug therapy , Bridged-Ring Compounds/adverse effects , Female , Humans , Scleroderma, Systemic/chemically induced , Scleroderma, Systemic/drug therapy , Taxoids/adverse effectsABSTRACT
Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle characterized by recurrent painful and inflamed lesions, predominantly affecting intertriginous regions. Due to its physical sequelae and impact on quality of life, we should be familiarized with this disease to make an appropriate diagnosis and implement an early treatment. This executive summary of the clinical guideline, elaborated by the hidradenitis suppurativa workgroup of the Chilean Society of Dermatology and Venereology (SOCHIDERM), reviews its definition, epidemiology, pathophysiology, risk factors, comorbidities, psycho-emotional impact, clinical presentation, diagnosis, classifications, ultrasonographic evaluation, and its medical and surgical treatments. Finally, a therapeutic approach algorithm is proposed.
Subject(s)
Humans , Hidradenitis Suppurativa/drug therapy , Hidradenitis Suppurativa/therapy , Quality of Life , Comorbidity , Chile , Risk FactorsABSTRACT
ABSTRACT Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. We report two cases with stage IV breast cancer, aged 66 and 71 years, who developed sclerodermic skin lesions in their extremities after starting treatment with placlitaxel and nabplaclitaxel respectively.
Los taxanos son agentes quimioterapéuticos cuyo uso se asocia a problemas dermatológicos tales como hiperpigmentación, síndrome manos-pies, paroniquia y onicolisis. La esclerodermia inducida por taxanos es rara, con pocos casos informados en la literatura. Informamos los casos de dos pacientes con cáncer de mama en estado IV, de 66 y 71 años, que desarrollaron lesiones esclerodérmicas en las extremidades después de ser tratadas con placlitaxel y nabplaclitaxel, respectivamente.
Subject(s)
Humans , Female , Scleroderma, Systemic/chemically induced , Scleroderma, Systemic/drug therapy , Breast Neoplasms/drug therapy , Antineoplastic Agents/adverse effects , Bridged-Ring Compounds/adverse effects , Taxoids/adverse effectsABSTRACT
Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle characterized by recurrent painful and inflamed lesions, predominantly affecting intertriginous regions. Due to its physical sequelae and impact on quality of life, we should be familiarized with this disease to make an appropriate diagnosis and implement an early treatment. This executive summary of the clinical guideline, elaborated by the hidradenitis suppurativa workgroup of the Chilean Society of Dermatology and Venereology (SOCHIDERM), reviews its definition, epidemiology, pathophysiology, risk factors, comorbidities, psycho-emotional impact, clinical presentation, diagnosis, classifications, ultrasonographic evaluation, and its medical and surgical treatments. Finally, a therapeutic approach algorithm is proposed.
Subject(s)
Hidradenitis Suppurativa , Chile , Comorbidity , Hidradenitis Suppurativa/drug therapy , Hidradenitis Suppurativa/therapy , Humans , Quality of Life , Risk FactorsABSTRACT
La hidradenitis supurativa es una enfermedad inflamatoria crónica del folículo piloso que se caracteriza por la aparición recurrente de lesiones inflamatorias dolorosas y profundas predominantemente en pliegues. Debido a sus secuelas físicas y en la calidad de vida, debemos estar familiarizados con esta enfermedad, a fin de poder realizar un diagnóstico oportuno e implementar un tratamiento precoz. Esta guía clínica, elaborada por el grupo de trabajo de hidradenitis supurativa de la Sociedad Chilena de Dermatología y Venereología (SOCHIDERM), revisa su definición, epidemiología, fisiopatogenia, factores de riesgo, comorbilidades, impacto psicoemocional, presentación clínica, diagnóstico, clasificaciones, evaluación ecográfica, y tratamientos médico y quirúrgico. Finalmente se propone un algoritmo de enfrentamiento terapéutico.
Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle characterized by recurrent painful and inflamed lesions, predominantly affecting intertriginous regions. Due to its physical sequelae and impact on life quality, we should be familiarized with this disease to make an appropriate diagnosis and implement an early treatment. This clinical guideline, elaborated by the hidradenitis suppurativa workgroup of the Chilean Society of Dermatology and Venereology (SOCHIDERM), review its definition, epidemiology, pathophysiology, risk factors, comorbidities, psycho-emotional impact, clinical presentation, diagnosis, classifications, ultrasonographic evaluation, and its medical and surgical treatments. Finally, a therapeutic approach algorithm is proposed.
Subject(s)
Humans , Hidradenitis Suppurativa/diagnosis , Hidradenitis Suppurativa/therapy , Algorithms , Chile , Risk Factors , Hidradenitis Suppurativa/classification , Hidradenitis Suppurativa/complications , Diagnosis, DifferentialABSTRACT
A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After 3 days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance. Histology characteristically reveals a dense, neutrophilic infiltrate with leucocitoclasis but without other signs of vasculitis. Lesions may resolve spontaneously or with RA treatment. This case illustrates an uncommon skin manifestation of active rheumatoid arthritis.
Subject(s)
Arthritis, Rheumatoid/pathology , Skin Diseases, Vesiculobullous/pathology , Biopsy , Erythema/pathology , Female , Humans , Middle Aged , Neutrophils/pathology , Skin/pathologyABSTRACT
Eosinophilic annular erythema is a rare, benign, recurrent disease, clinically characterized by persistent, annular, erythematous lesions, revealing histopathologically perivascular infiltrates with abundant eosinophils. This report describes an unusual case of eosinophilic annular erythema in a 3-year-old female, requiring sustained doses of hydroxychloroquine to be adequately controlled.
Subject(s)
Eosinophilia/pathology , Erythema/blood , Erythema/pathology , Skin Diseases, Genetic/blood , Skin Diseases, Genetic/pathology , Biopsy , Child, Preschool , Eosinophils/pathology , Female , Humans , Skin/pathologyABSTRACT
Abstract: Eosinophilic annular erythema is a rare, benign, recurrent disease, clinically characterized by persistent, annular, erythematous lesions, revealing histopathologically perivascular infiltrates with abundant eosinophils. This report describes an unusual case of eosinophilic annular erythema in a 3-year-old female, requiring sustained doses of hydroxychloroquine to be adequately controlled.
Subject(s)
Humans , Female , Child, Preschool , Skin Diseases, Genetic/pathology , Skin Diseases, Genetic/blood , Eosinophilia/pathology , Erythema/pathology , Erythema/blood , Skin/pathology , Biopsy , Eosinophils/pathologyABSTRACT
Abstract: A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After 3 days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance. Histology characteristically reveals a dense, neutrophilic infiltrate with leucocitoclasis but without other signs of vasculitis. Lesions may resolve spontaneously or with RA treatment. This case illustrates an uncommon skin manifestation of active rheumatoid arthritis.
Subject(s)
Humans , Female , Middle Aged , Arthritis, Rheumatoid/pathology , Skin Diseases, Vesiculobullous/pathology , Skin/pathology , Biopsy , Erythema/pathology , Neutrophils/pathologyABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Amyloidosis/diagnosis , Multiple Myeloma/diagnosis , Multiple Myeloma/drug therapy , Skin Diseases, VesiculobullousABSTRACT
Erosive lichen planus is an uncommon variant of lichen planus. Chronic erosions of the soles, accompanied by intense and disabling pain, are some of its most characteristic manifestations. We present the case of a woman who developed oral and plantar erosive lichen planus associated with lichen planus pigmentosus and ungueal lichen planus that were diagnosed after several years. The patient failed to respond to multiple therapies requiring longstanding medication but remained refractory. Knowledge of the treatment options for erosive lichen planus is insufficient. Further research is required to clarify their effectiveness, ideally adopting an evidence-based methodology.
Subject(s)
Foot Dermatoses/drug therapy , Foot Dermatoses/pathology , Lichen Planus/drug therapy , Lichen Planus/pathology , Adrenal Cortex Hormones/therapeutic use , Aged , Dermatologic Agents/therapeutic use , Female , Humans , Treatment FailureABSTRACT
Abstract Erosive lichen planus is an uncommon variant of lichen planus. Chronic erosions of the soles, accompanied by intense and disabling pain, are some of its most characteristic manifestations. We present the case of a woman who developed oral and plantar erosive lichen planus associated with lichen planus pigmentosus and ungueal lichen planus that were diagnosed after several years. The patient failed to respond to multiple therapies requiring longstanding medication but remained refractory. Knowledge of the treatment options for erosive lichen planus is insufficient. Further research is required to clarify their effectiveness, ideally adopting an evidence-based methodology.
Subject(s)
Aged , Female , Humans , Foot Dermatoses/drug therapy , Foot Dermatoses/pathology , Lichen Planus/drug therapy , Lichen Planus/pathology , Adrenal Cortex Hormones/therapeutic use , Dermatologic Agents/therapeutic use , Treatment FailureSubject(s)
Carcinoma, Renal Cell/secondary , Kidney Neoplasms/pathology , Nose Neoplasms/secondary , Skin Neoplasms/secondary , Aged , Angiogenesis Inhibitors/therapeutic use , Biomarkers, Tumor/analysis , Biopsy , Carcinoma, Renal Cell/chemistry , Carcinoma, Renal Cell/therapy , Fatal Outcome , Humans , Immunohistochemistry , Indazoles , Kidney Neoplasms/chemistry , Kidney Neoplasms/therapy , Male , Neoplasm Recurrence, Local , Nose Neoplasms/chemistry , Nose Neoplasms/therapy , Pyrimidines/therapeutic use , Skin Neoplasms/chemistry , Skin Neoplasms/therapy , Sulfonamides/therapeutic use , Time Factors , Treatment OutcomeABSTRACT
Postirradiation pseudosclerodermatous panniculitis presents as an erythematous indurated plaque, on a previously irradiated area. Histopathologically, thick and sclerotic septa and inflammatory infiltrate with foamy histiocytes and adiponecrosis are seen. To date, 12 cases have been reported worldwide. Hereby, we report the case of a 68-year-old woman who developed an indurated painful erythematous plaque on her right leg after radiotherapy for a soft tissue sarcoma, with a septal panniculitis and lobular adiponecrosis on histopathological examination. This is the 13th case reported and the second of extrathoracic location.
Subject(s)
Leg Dermatoses/pathology , Panniculitis/pathology , Radiodermatitis/pathology , Skin/radiation effects , Aged , Female , Humans , Leg Dermatoses/etiology , Liposarcoma/radiotherapy , Panniculitis/etiology , Radiodermatitis/etiology , Radiotherapy, Adjuvant/adverse effects , Sclerosis , Skin/pathology , Soft Tissue Neoplasms/radiotherapyABSTRACT
Skin necrosis must be considered as a syndrome, because it is a clinical manifestation of different diseases. An early diagnosis is very important to choose the appropriate treatment. Therefore, its causes should be suspected and confirmed quickly. We report eleven patients with skin necrosis seen at our Department, caused by different etiologies: Warfarin-induced skin necrosis, loxoscelism, diabetic microangiopathy, ecthyma gangrenosum, disseminated intravascular coagulation, necrotizing vasculitis, paraneoplastic extensive necrotizing vasculitis, livedoid vasculopathy, necrotizing fasciitis, necrosis secondary to the use of vasoactive drugs and necrosis secondary to the use of cocaine. We also report the results of our literature review on the subject.
Subject(s)
Skin Diseases/pathology , Skin/pathology , Adult , Aged , Female , Humans , Male , Middle Aged , Necrosis/etiology , Skin Diseases/etiologyABSTRACT
BACKGROUND: Scleromyxedema is a rare generalized form of lichen myxedematosus, a chronic cutaneous mucinosis of unknown etiology usually associated with a monoclonal gammopathy and underlying systemic disorders. It is characterized by the presence of lichenoid papules and diffuse indurations of the skin. Histologically, mucin deposits are observed in the dermis as variable degrees of fibrosis. Numerous treatment modalities have been reported as producing partial or inconsistent responses associated with significant adverse effects. METHODS: We report an unusual case of scleromyxedema not associated with monoclonal gammopathy in a young patient who was treated with thalidomide. RESULTS: Patient remained stable with maintenance of injuries despite treatment with thalidomide. CONCLUSIONS: Scleromyxedema is a rare presentation for which a defined therapeutic regimen remains to be established. Treatment with thalidomide has proved to be effective in the management of these patients. We suggest that these patients should be followed up with periodic protein electrophoresis with immunofixation for a monoclonal component in blood and urine. As the therapeutic approach to scleromyxedema remains challenging and treatment is based on symptomatic presentation, further clinical studies to substantiate an effective therapeutic regimen with a positive long-term safety and risk profile are required.
Subject(s)
Immunosuppressive Agents/therapeutic use , Scleromyxedema/blood , Scleromyxedema/drug therapy , Thalidomide/therapeutic use , Adolescent , Humans , Male , Paraproteinemias/blood , Scleromyxedema/pathologyABSTRACT
Background: Bacillary angiomatosis is an unusual infectious disease, with angioproliferative lesions, typical of immunocompromised patients. It is caused by Bartonella quintana and Bartonella henselae, two infectious agents of the genus Bartonella, which trigger variable clinical manifestations, including cutaneous vascular and purpuric lesions, and regional lymphadenopathy, and even a systemic disease with visceral involvement. We report a 38-year-old HIV positive male presenting with a history of six months of cutaneous growing purple angiomatous lesions, located also in nasal fossae, rhi-nopharynx and larynx. The skin biopsy was compatible with bacillary angiomatosis. Polymerase chain reaction of a tissue sample showed homology with B. quintana strain Toulouse. The patient was treated with azithromycin and ciprofloxacin with a favorable evolution.