ABSTRACT
AIM: Aerosols released from the oral cavity help spread the SARS-CoV-2 virus. The use of a mouthwash formulated with an antiviral agent could reduce the viral load in saliva, helping to lower the spread of the virus. The aim of this study was to assess the efficacy of a mouthwash with 0.07% cetylpyridinium chloride (CPC) to reduce the viral load in the saliva of Coronavirus disease 2019 (COVID-19) patients. MATERIALS AND METHODS: In this multi-centre, single-blind, randomized, parallel group clinical trial, 80 COVID-19 patients were enrolled and randomized to two groups, namely test (n = 40) and placebo (n = 40). Saliva samples were collected at baseline and 2 h after rinsing. The samples were analysed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and an enzyme-linked immunosorbent assay test specific for the nucleocapsid (N) protein of SARS-CoV-2. RESULTS: With RT-qPCR, no significant differences were observed between the placebo group and the test group. However, 2 h after a single rinse, N protein concentration in saliva was significantly higher in the test group, indicating an increase in lysed virus. CONCLUSIONS: The use of 0.07% CPC mouthwash induced a significant increase in N protein detection in the saliva of COVID-19 patients. Lysis of the virus in the mouth could help reduce the transmission of SARS-CoV-2. However, more studies are required to prove this.
Subject(s)
COVID-19 , SARS-CoV-2 , Humans , COVID-19/prevention & control , Cetylpyridinium/therapeutic use , Mouthwashes/therapeutic use , Viral Load , Single-Blind MethodABSTRACT
Las heridas de evolución tórpida y compleja suponen un desafío para las enfermeras por su multicausalidad. Asimismo, la diferencia de criterios entre las profesionales podría generar una falta de continuidad en los tratamientos que comprometería su resolución. Por ello, es necesario unificar criterios para su prevención, diagnóstico y tratamiento con el fin de mejorar la continuidad de los cuidados. La curación de estas heridas es un proceso complejo y dinámico que implica la modificación del entorno de la herida según el estado de salud del paciente. El tratamiento local se basa en los principios de cura en ambiente húmedo (CAH) y en la preparación del lecho. El objeto de este artículo es describir los resultados de la aplicación de la propuesta Clean & Close, basada en la aplicación secuencial de dos nuevos apósitos, que, por un lado, estimulan el desbridamiento del tejido necrótico húmedo y el control de la infección (Kytocel: apósito de fibras de Quitosán) y, por otro, estimulan la producción de tejido de granulación y el proceso de angiogénesis, acelerando la cicatrización de las heridas (Trionic(R): apósito bioactivo con carga iónica). Consideramos que pueden ser una alternativa efectiva en el tratamiento de este tipo de heridas
Complex wounds with torpid evolution represent a challenge for nursing professionals due to their multicausality. Differences of criteria among professionals could eventually lead to treatment discontinuities compromising wound healing. It is therefore necessary to unify criteria for complex wound prevention, diagnosis and treatment in order to improve continuity of care. The healing of chronic wounds involves a complex and dynamic process, which requires modulating wound environment depending on the patient's state of health. Local treatment is based on the principles of moist wound healing (MWH) and wound bed preparation. The purpose of this article is to describe the results of the new Clean & Close treatment proposal. It is based on the sequential application of two new dressings which, on the one hand, stimulate the debridement of slough tissue and favor infection control (Kytocel: chitosan fibers dressing), and on the other, stimulate the production of granulation tissue and the process of angiogenesis, accelerating wound healing (Trionic(R): bioactive ionic dressing). We consider that the Clean & Close proposal can be an effective alternative treatment for these types of complex, chronic, hard-to-heal wounds