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1.
Scand J Med Sci Sports ; 30(7): 1221-1231, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32201993

ABSTRACT

BACKGROUND: Conflicting and limited high-quality prospective data are available on the associations between cam morphology and hip and groin symptoms and range of motion (ROM). OBJECTIVES: This cross-sectional cohort study investigated associations between cam morphology presence, size and duration and symptoms and ROM. METHODS: Academy male football players (n = 49, 17-24 years) were included. Standardized antero-posterior pelvic and frog-leg lateral radiographs were obtained at baseline, 2.5- and 5-year follow-up. The femoral head-neck junction was quantified by: Visual score. Cam morphology (flattening or prominence), large cam (prominence). Alpha angle. Cam morphology (≥60°), large cam (≥78°). Cam morphology duration was defined as long (first present at baseline) or short (only from 2.5- to 5-year follow-up). Current symptoms at 5-year follow-up were assessed using a hip and groin pain question and by the "Hip and Groin Outcome Score" (HAGOS). HAGOS scores were categorized into: most symptoms (≥2 domains in lowest interquartile range [IQR]), least symptoms (≥2 domains in highest IQR). Hip ROM was measured by goniometry at 5-year follow-up. RESULTS: Large cam morphology based on visual score was associated with hip and groin pain (23.8% vs. 7.1%, OR: 3.17, CI: [1.15-8.70], P = .026), but not with HAGOS scores. Cam morphology presence, size, and duration were associated with limited flexion of around 6° and/or 3° to 6° for internal rotation. CONCLUSION: Cam morphology presence, size, and duration were associated with limited hip flexion and/or internal rotation, but differences might not exceed the minimal clinical important difference. Whether cam morphology results in symptoms is uncertain.


Subject(s)
Groin/physiopathology , Hip Joint/diagnostic imaging , Hip Joint/physiopathology , Musculoskeletal Pain/diagnostic imaging , Musculoskeletal Pain/physiopathology , Soccer , Adolescent , Adult , Athletes , Humans , Male , Pain Measurement , Range of Motion, Articular , Surveys and Questionnaires , Young Adult
2.
Br J Sports Med ; 53(9): 532-538, 2019 May.
Article in English | MEDLINE | ID: mdl-30323059

ABSTRACT

OBJECTIVES: Cam morphology is not completely understood. The aim of this study was threefold: (1) to investigate if cam morphology development is associated with growth plate status; (2) to examine whether cam morphology continues to develop after growth plate closure; and (3) to qualitatively describe cam morphology development over 5-year follow-up. METHODS: Academy male football players (n=49) participated in this prospective 5-year follow-up study (baseline 12-19 years old). Anteroposterior and frog-leg lateral views were obtained at baseline (142 hips), 2.5-year (126 hips) and 5-year follow-up (98 hips). Cam morphology on these time points was defined as: (A) visual scores of the anterior head-neck junction, classified as: (1) normal, (2) flattening, and (3) prominence; and (B) alpha angle ≥60°. Proximal femoral growth plates were classified as open or closed. Cam morphology development was defined as every increase in visual score and/or increase in alpha angle from <60° to ≥60°, between two time points. This resulted in 224 measurements for cam morphology development analysis. RESULTS: Cam morphology development was significantly associated with open growth plates based on visual score (OR: 10.03, 95% CI 3.49 to 28.84, p<0.001) and alpha angle (OR: 2.85, 95% CI 1.18 to 6.88, p=0.020). With both definitions combined, cam developed in 104 of 142 hips during follow-up. Of these 104 hips, cam developed in 86 hips (82.7%) with open growth plate and in 18 hips (17.3%) with a closed growth plate. Cam morphology developed from 12 to 13 years of age until growth plate closure around 18 years. CONCLUSION: Cam morphology of the hip is more likely to develop with an open growth plate.


Subject(s)
Femur/anatomy & histology , Growth Plate/anatomy & histology , Hip Joint/anatomy & histology , Adolescent , Athletes , Child , Femur/diagnostic imaging , Follow-Up Studies , Growth Plate/diagnostic imaging , Hip Joint/diagnostic imaging , Humans , Male , Osteogenesis , Prospective Studies , Soccer
3.
Chiropr Man Therap ; 26: 37, 2018.
Article in English | MEDLINE | ID: mdl-30151119

ABSTRACT

Main text: We aim to summarize the available evidence on the diagnostic accuracy of imaging (index test) compared to surgery (reference test) for identifying lumbar disc herniation (LDH) in adult patients.For this systematic review we searched MEDLINE, EMBASE and CINAHL (June 2017) for studies that assessed the diagnostic accuracy of imaging for LDH in adult patients with low back pain and surgery as the reference standard. Two review authors independently selected studies, extracted data and assessed risk of bias. We calculated summary estimates of sensitivity and specificity using bivariate analysis, generated linked ROC plots in case of direct comparison of diagnostic imaging tests and assessed the quality of evidence using the GRADE-approach.We found 14 studies, all but one done before 1995, including 940 patients. Nine studies investigated Computed Tomography (CT), eight myelography and six Magnetic Resonance Imaging (MRI). The prior probability of LDH varied from 48.6 to 98.7%. The summary estimates for MRI and myelography were comparable with CT (sensitivity: 81.3% (95%CI 72.3-87.7%) and specificity: 77.1% (95%CI 61.9-87.5%)). The quality of evidence was moderate to very low. Conclusions: The diagnostic accuracy of CT, myelography and MRI of today is unknown, as we found no studies evaluating today's more advanced imaging techniques. Concerning the older techniques we found moderate diagnostic accuracy for all CT, myelography and MRI, indicating a large proportion of false positives and negatives.


Subject(s)
Intervertebral Disc Displacement/diagnostic imaging , Low Back Pain/diagnostic imaging , Magnetic Resonance Imaging/standards , Myelography/standards , Sciatica/diagnostic imaging , Tomography Scanners, X-Ray Computed/standards , Humans , Intervertebral Disc Displacement/diagnosis , Low Back Pain/diagnosis , Lumbosacral Region/diagnostic imaging , Randomized Controlled Trials as Topic , Sciatica/diagnosis
4.
Am J Sports Med ; 42(4): 798-806, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24585362

ABSTRACT

BACKGROUND: A cam deformity is a major risk factor for hip osteoarthritis, and its formation is thought to be influenced by high-impact sporting activities during growth. PURPOSE: To (1) prospectively study whether a cam deformity can evolve over time in adolescents and whether its formation only occurs during skeletal maturation and (2) examine whether clinical or radiographic features can predict the formation of a cam deformity. STUDY DESIGN: Cohort study (prognosis); Level of evidence, 2. METHODS: Preprofessional soccer players (N = 63; mean age, 14.43 years; range, 12-19 years) participated both at baseline and follow-up (mean follow-up, 2.4 ± 0.06 years). At both time points, standardized anteroposterior and frog-leg lateral radiographs were obtained. For each hip, the α angle was measured, and the anterosuperior head-neck junction was classified by a 3-point visual system as normal, flattened, or having a prominence. Differences between baseline and follow-up values for the α angle and the prevalence of each visual hip classification were calculated. Additionally, the amount of internal hip rotation, growth plate extension into the neck, and neck shaft angle were determined. RESULTS: Overall, there was a significant increase in the prevalence of a cam deformity during follow-up. In boys aged 12 and 13 years at baseline, the prevalence of a flattened head-neck junction increased significantly during follow-up (13.6% to 50.0%; P = .002). In all hips with an open growth plate at baseline, the prevalence of a prominence increased from 2.1% to 17.7% (P = .002). After closure of the proximal femoral growth plate, there was no significant increase in the prevalence or increase in severity of a cam deformity. The α angle increased significantly from 59.4° at baseline to 61.3° at follow-up (P = .018). The amount of growth plate extension was significantly associated with the α angle and hip classification (P = .001). A small neck shaft angle and limited internal rotation were associated with cam deformities and could also significantly predict the formation of cam deformities (α angle >60°) at follow-up. CONCLUSION: In youth soccer players, cam deformities gradually develop during skeletal maturation and are probably stable from the time of growth plate closure. The formation of a cam deformity might be prevented by adjusting athletic activities during a small period of skeletal growth, which will have a major effect on the prevalence of hip osteoarthritis.


Subject(s)
Femoracetabular Impingement/etiology , Osteoarthritis, Hip/etiology , Soccer/physiology , Adolescent , Adolescent Development , Child , Disease Progression , Femoracetabular Impingement/diagnostic imaging , Femoracetabular Impingement/pathology , Follow-Up Studies , Growth Plate/diagnostic imaging , Growth Plate/pathology , Humans , Male , Osteoarthritis, Hip/diagnostic imaging , Prevalence , Prognosis , Prospective Studies , Radiography , Risk Factors , Rotation , Young Adult
5.
Am J Sports Med ; 40(5): 1099-106, 2012 May.
Article in English | MEDLINE | ID: mdl-22415206

ABSTRACT

BACKGROUND: Cam impingement is a well-recognized cause of hip pain and might cause osteoarthritis of the hip. Clinically, cam impingement is mostly observed in young, active male patients, but only a few studies have focused on the manifestation of cam-type deformities during skeletal development. PURPOSE: To determine the age of onset and prevalence of cam-type deformities in young male soccer players versus controls. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: In this study, 89 elite preprofessional soccer players and 92 controls aged 12 to 19 years were included. In the soccer players, range of motion and impingement tests were performed. Both an anteroposterior (AP) pelvic radiograph and a frog-leg lateral radiograph of the hip were obtained according to a standardized protocol. Controls with both an AP pelvic and a frog-leg lateral radiograph and no hip disorders were obtained from radiology databases. The α angle was automatically determined in all radiographs, using a threshold value of 60° to define a cam-type deformity. Further, all radiographs were scored using a 3-point scoring system. The anterosuperior head-neck junction was classified as (1) normal, (2) flattened, or (3) having a prominence. Differences in prevalence were tested using logistic regression. Differences in range of motion were calculated using generalized estimating equations. RESULTS: An α angle >60° was already found at the age of 12 years in some soccer players and controls. A cam-type deformity defined by α angle tended to be more prevalent in soccer players (26%) than in controls (17%; P = .31). In 13% of soccer players, a prominence was visible on radiographs and was first seen at the age of 13 years. The anterosuperior flattening (56% vs 18%, P = .0001) and prominence (13% vs 0%, P < .03) were more prevalent in soccer players than in controls. CONCLUSION: Cam-type deformities were recognizable and present from the age of 13 years and were more prevalent in soccer players than in their nonathletic peers. Cam-type deformity develops during adolescence and is likely to be influenced by high-impact sports practice.


Subject(s)
Femoracetabular Impingement/etiology , Hip Joint/pathology , Soccer , Adolescent , Adolescent Development , Child , Child Development , Cross-Sectional Studies , Femoracetabular Impingement/diagnostic imaging , Femoracetabular Impingement/pathology , Femoracetabular Impingement/physiopathology , Hip Joint/diagnostic imaging , Hip Joint/physiopathology , Humans , Linear Models , Logistic Models , Male , Radiography , Range of Motion, Articular , Soccer/physiology , Young Adult
6.
Skeletal Radiol ; 41(2): 193-202, 2012 Feb.
Article in English | MEDLINE | ID: mdl-21533651

ABSTRACT

OBJECTIVE: To evaluate the additional value of a 45° oblique MRI scan plane for assessing the anterior and posterior distal tibiofibular syndesmotic ligaments in patients with an acute ankle fracture. MATERIALS AND METHODS: Prospectively, data were collected for 44 consecutive patients with an acute ankle fracture who underwent a radiograph (AP, lateral, and mortise view) as well as an MRI in both the standard three orthogonal planes and in an additional 45° oblique plane. The fractures on the radiographs were classified according to Lauge-Hansen (LH). The anterior (ATIFL) and posterior (PTIFL) distal tibiofibular ligaments, as well as the presence of a bony avulsion in both the axial and oblique planes was evaluated on MRI. MRI findings regarding syndesmotic injury in the axial and oblique planes were compared to syndesmotic injury predicted by LH. Kappa and the agreement score were calculated to determine the interobserver agreement. The Wilcoxon signed rank test and McNemar's test were used to compare the two scan planes. RESULTS: The interobserver agreement (κ) and agreement score [AS (%)] regarding injury of the ATIFL and PTIFL and the presence of a fibular or tibial avulsion fracture were good to excellent in both the axial and oblique image planes (κ 0.61-0.92, AS 84-95%). For both ligaments the oblique image plane indicated significantly less injury than the axial plane (p < 0.001). There was no significant difference in detection of an avulsion fracture in the axial or oblique plane, neither anteriorly (p = 0.50) nor posteriorly (p = 1.00). With syndesmotic injury as predicted by LH as comparison, the specificity in the oblique MR plane increased for both anterior (to 86% from 7%) and posterior (to 86% from 48%) syndesmotic injury when compared to the axial plane. CONCLUSION: Our results show the additional value of an 45° oblique MR image plane for detection of injury of the anterior and posterior distal tibiofibular syndesmoses in acute ankle fractures. Findings of syndesmotic injury in the oblique MRI plane were closer to the diagnosis as assumed by the Lauge-Hansen classification than in the axial plane. With more accurate information, the surgeon can better decide when to stabilize syndesmotic injury in acute ankle fractures.


Subject(s)
Ankle Injuries/pathology , Fractures, Bone/pathology , Joint Instability/pathology , Ligaments, Articular/injuries , Ligaments, Articular/pathology , Magnetic Resonance Imaging/methods , Acute Disease , Adolescent , Adult , Aged , Female , Fibula/injuries , Fibula/pathology , Humans , Male , Middle Aged , Observer Variation , Reproducibility of Results , Sensitivity and Specificity , Tibia/injuries , Tibia/pathology , Young Adult
7.
Eur Spine J ; 21(2): 228-39, 2012 Feb.
Article in English | MEDLINE | ID: mdl-21915747

ABSTRACT

AIM: In low back pain if serious pathology is suspected diagnostic imaging could be performed. One of the imaging techniques available for this purpose is computed tomography (CT), however, insight in the diagnostic performance of CT is unclear. METHOD: Diagnostic systematic review. Studies assessing the diagnostic accuracy of CT in adult patients suggested having low back pain caused by specific pathology were selected. Two review authors independently selected studies for inclusion, extracted data and assessed risk of bias. Pooled summary estimates of sensitivity and specificity with 95% CI were calculated. RESULTS: Seven studies were included, all describing the diagnostic accuracy of CT in identifying lumbar disc herniation. Six studies used surgical findings as the reference standard and were considered sufficiently homogenous to carry out a meta-analysis. The pooled summary estimate of sensitivity was 77.4% and specificity was 73.7%. CONCLUSIONS: We found no studies evaluating the accuracy of CT for pathologies such as vertebral cancer, infection and fractures and this remains unclear. Our results should be interpreted with some caution. Sensitivity and specificity, regarding the detection of lumbar disc herniation, showed that a substantial part of the patients is still classified as false-negative and false-positive. In future, the diagnostic performance of CT must be assessed in high quality prospective cohort studies with an unselected population of patients with low back pain.


Subject(s)
Low Back Pain/diagnostic imaging , Lumbar Vertebrae/diagnostic imaging , Sciatica/diagnostic imaging , Spinal Diseases/diagnostic imaging , Tomography, X-Ray Computed , Humans
8.
Eur Spine J ; 21(2): 220-7, 2012 Feb.
Article in English | MEDLINE | ID: mdl-21922287

ABSTRACT

PURPOSE: In about 5% of all cases LBP is associated with serious underlying pathology requiring diagnostic confirmation and directed treatment. Magnetic resonance imaging (MRI) is often used for this diagnostic purpose yet its role remains controversial. Consequently, this review aimed to summarize the available evidence on the diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients. METHODS: MEDLINE, EMBASE and CINAHL were searched (until December 2009) for observational studies assessing the diagnostic accuracy of MRI compared to a reference test for the identification of lumbar spinal pathology. Two reviewers independently selected studies for inclusion, extracted data and assessed methodological quality. Pooled summary estimates of sensitivity and specificity with 95% confidence intervals were calculated for homogenous subsets of studies. RESULTS: Eight studies were included in this review. Strata were defined for separate pathologies i.e. lumbar disc herniation (HNP) and spinal stenosis. Five studies comparing MRI to findings at the surgery for identifying HNP were included in a meta-analysis. Pooled analysis resulted in a summary estimate of sensitivity of 75% (95% CI 65-83%) and specificity of 77% (95% CI 61-88%). For spinal stenosis pooling was not possible. CONCLUSIONS: The results suggest that a considerable proportion of patients may be classified incorrectly by MRI for HNP and spinal stenosis. However, the evidence for the diagnostic accuracy of MRI found by this review is not conclusive, since the results could be distorted due to the limited number of studies and large heterogeneity.


Subject(s)
Low Back Pain/pathology , Lumbar Vertebrae/pathology , Magnetic Resonance Imaging , Sciatica/pathology , Spinal Diseases/diagnosis , Humans
9.
Skeletal Radiol ; 40(1): 75-83, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20549205

ABSTRACT

OBJECTIVE: The optimal MRI scan planes of collateral ligaments of the ankle have been described extensively, with the exception of the syndesmotic ligaments. We assessed the optimal scan plane for depicting the distal tibiofibular syndesmosis. MATERIALS AND METHODS: In order to determine the optimal oblique caudal-cranial and lateral-medial MRI scan plane, two fresh frozen cadaveric ankles were used. The angle of the scan plane that demonstrated the anterior and posterior distal tibiofibular ligament uninterrupted in their full length was determined. In a prospective study this oblique scan plane was then used in addition to the axial and coronal planes, for MRI scans of both ankles in 21 healthy volunteers. Two observers independently evaluated the anterior tibiofibular ligament (ATIFL) and posterior tibiofibular ligament (PTIFL) regarding the continuity of the individual fascicles, thickness and wavy contour of the ligaments in both the axial and the oblique plane. Kappa was calculated to determine the interobserver agreement. McNemar's test was used to statistically quantify the significance of the two scan planes. RESULTS: In the axial plane the ATIFL was in 31% (13/42) partly and in 69% (29/42) completely discontinuous; in the oblique plane the ATIFL was continuous in 88% (37/42) and partly discontinuous in 12% (5/42). Compared with the axial plane, the oblique plane demonstrated significantly less discontinuity (p<0.001), but not significantly less thickening (p=1.00) or less wavy contour (p=0.06) of the ATIFL. In the axial scan plane the PTIFL was continuous in 76% (32/42), partially discontinuous in 19% (8/42) and completely discontinuous in 5% (2/42); in the oblique plane the PTIFL was continuous in 100% (42/42). Compared with the axial plane, the oblique plane demonstrated significantly less discontinuity (p=0.002), but not significantly less thickening (p=1.00) or less wavy contour (p=0.50) of the PTIFL. The interobserver agreement score and kappa (κ) regarding the continuity for the ATIFL in the axial and oblique planes was 91% (κ=0.79) and 91% (κ=0.55) respectively; for the PTIFL it was 86% (κ=0.65) and 100% (κ = not defined). CONCLUSION: The ATIFL and PTIFL are routinuely scanned in the orthogonal planes. The advantage of MRI scanning in an oblique image plane of about 45 degrees permits a better evaluation of the ligaments compared with the axial plane, particularly a better interpretation of ligament continuity, thickening and wavy contour. This may lead to a reduction in false-positive results, especially regarding partial or complete ligament ruptures. This can be of considerable aid in therapeutic management.


Subject(s)
Fibula/diagnostic imaging , Ligaments, Articular/diagnostic imaging , Magnetic Resonance Imaging/methods , Tibia/diagnostic imaging , Humans , Observer Variation , Radiography
10.
Spine (Phila Pa 1976) ; 35(5): 531-6, 2010 Mar 01.
Article in English | MEDLINE | ID: mdl-20147869

ABSTRACT

STUDY DESIGN: Cross-sectional open population based study (nested in a prospective cohort study). OBJECTIVE: To explore the association of the different individual radiographic features, including osteophytes and disc space narrowing, with self-reported low back pain (LBP). Different definitions of lumbar disc degeneration with self-reported LBP and disability were considered in a large open population sample. Furthermore, in order to disentangle the discrepancies in reported strength of the associations, we characterized the frequency of the different individual radiographic features of lumbar disc degeneration and definitions of lumbar disc degeneration, as well as their association with LBP status, by age, gender, and vertebral level. SUMMARY OF BACKGROUND DATA: Currently within the literature, there have been no studies that have explored different definitions of lumbar disc degeneration and their association with LBP within one study sample. METHODS: The intervertebral disc spaces (L1/2 to L5-S1) were evaluated for the presence and severity of anterior osteophytes and disc space narrowing using a semiquantitative score (grade 0-3). Logistic regression was used to determine the association between these individual radiographic features of lumbar disc degeneration and different definitions of lumbar disc degeneration for LBP. RESULTS: Lumbar radiographs were scored for 1204 men, and 1615 women. Osteophytes were the most frequent radiographic feature observed, with men having the greatest frequency. Disc space narrowing was more frequent in women than men. Both radiographic features increased in frequency with age.Disc space narrowing appeared more strongly associated with LBP than osteophytes, especially in men (odds ratio [OR] = 1.9; 95% confidence interval [CI]: 1.4-2.8). Disc space narrowing at 2 or more levels appeared more strongly associated with LBP than disc space narrowing at only 1 level (OR = 2.4; 95% CI: 1.6-3.4). After excluding level L5-S1, the strength of almost all associations increased. CONCLUSION: We are the first to report different possible lumbar disc degeneration definitions and their associations with LBP. Disc space narrowing at 2 or more levels appeared more strongly associated with LBP than other radiographic features, especially after excluding level L5-S1.


Subject(s)
Intervertebral Disc Degeneration/complications , Intervertebral Disc Degeneration/diagnostic imaging , Low Back Pain/complications , Low Back Pain/diagnostic imaging , Lumbar Vertebrae/diagnostic imaging , Age Factors , Aged , Cohort Studies , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Odds Ratio , Osteophyte/diagnostic imaging , Radiography , Regression Analysis , Severity of Illness Index , Sex Factors
11.
J Foot Ankle Surg ; 48(2): 156-62, 2009.
Article in English | MEDLINE | ID: mdl-19232967

ABSTRACT

UNLABELLED: Comparing different types of calcaneal fractures, associated treatment options, and outcome data is currently hampered by the lack of consensus regarding fracture classification. A systematic search for articles dealing with calcaneal fracture was performed, and the prevalence of use of each classification system determined. Twelve observers classified 30 intra-articular calcaneal fractures according to the 3 most prevalent classification systems; interobserver reliability (kappa [kappa] statistic) and the correlation of the system with the choice of treatment and clinical outcomes were calculated. Forty-nine conventional and 15 computerized tomographic scan classification systems were identified. The most prevalent systems were the Essex-Lopresti, Zwipp, Crosby, and Sanders classifications; and none of these showed a direct correlation with treatment, although each of these systems showed positive correlations with outcome. Moderate interobserver agreement and variability were found for the Crosby and Sanders classifications (overall kappa = 0.48), whereas interobserver reliability among radiologists was poor for the Essex-Lopresti classification (overall kappa = 0.26). Four classifications systems showed positive correlations with outcome, but no correlation with choice of treatment. The Sanders and Crosby classifications displayed comparable, moderate interobserver variability among surgeons and radiologists, and both of these systems are likely to be useful for classification of intra-articular calcaneal fractures. LEVEL OF CLINICAL EVIDENCE: 5.


Subject(s)
Calcaneus/injuries , Fractures, Bone/classification , Fractures, Bone/diagnostic imaging , Fractures, Bone/surgery , Humans , Prognosis , Radiography
12.
Eur Radiol ; 19(2): 409-18, 2009 Feb.
Article in English | MEDLINE | ID: mdl-18795300

ABSTRACT

The aim of this study was to assess the costs and effectiveness of selective short magnetic resonance imaging (MRI) in patients with acute knee injury. A model was developed to evaluate the selective use of MRI in patients with acute knee injury and no fracture on radiography based on the results of a trial in which 208 patients were randomized between radiography only and radiography plus MRI. We analyzed medical (diagnostic and therapeutic) costs, quality of life, duration of diagnostic workup, number of additional diagnostic examinations, time absent from work, and time to convalescence during a 6-month follow-up period. Quality of life was lowest (EuroQol at 6 weeks 0.61 (95% CI 0.54-0.67)); duration of diagnostic workup, absence from work, and time to convalescence were longest; and the number of diagnostic examinations was largest with radiography only. These outcomes were more favorable for both MRI strategies (EuroQol at 6 weeks 0.72 (95% CI 0.67-0.77) for both). Mean total costs were 2,593 euros (95% CI 1,815-3,372) with radiography only, 2,116 euros (95% CI 1,488-2,743) with radiography plus MRI, and 1,973 euros (95% CI 1,401-2,543) with selective MRI. The results suggest that selective use of a short MRI examination saves costs and potentially increases effectiveness in patients with acute knee injury without a fracture on radiography.


Subject(s)
Knee Injuries/diagnostic imaging , Knee Injuries/diagnosis , Knee Injuries/pathology , Magnetic Resonance Imaging/economics , Magnetic Resonance Imaging/methods , Radiography/economics , Radiography/methods , Adult , Cost-Benefit Analysis , Female , Humans , Knee/diagnostic imaging , Knee/pathology , Knee Injuries/economics , Male , Models, Theoretical , Time Factors , Treatment Outcome , Wounds and Injuries/economics
13.
Ann Intern Med ; 148(4): 268-77, 2008 Feb 19.
Article in English | MEDLINE | ID: mdl-18283204

ABSTRACT

BACKGROUND: The effectiveness of glucosamine sulfate as a symptom and disease modifier for osteoarthritis is still under debate. OBJECTIVE: To assess whether glucosamine sulfate has an effect on the symptoms and structural progression of hip osteoarthritis during 2 years of treatment. DESIGN: Randomized, controlled trial. SETTING: Primary care in the Netherlands. PATIENTS: 222 patients with hip osteoarthritis who were recruited by their general practitioner. Patients were eligible if they met the American College of Rheumatology clinical criteria for hip osteoarthritis. INTERVENTION: 2 years of treatment with 1500 mg of oral glucosamine sulfate or placebo once daily. MEASUREMENTS: Primary outcome measures were Western Ontario and McMaster Universities (WOMAC) pain and function subscales over 24 months and joint space narrowing after 24 months. The main secondary outcome measures were WOMAC pain, function, and stiffness after 3, 12, and 24 months. RESULTS: At baseline, both groups were similar in demographic and clinical variables. Overall, WOMAC pain did not differ (mean difference [glucosamine sulfate minus placebo], -1.54 [95% CI, -5.43 to 2.36]), nor did WOMAC function (mean difference, -2.01 [CI, -5.38 to 1.36]). Joint space narrowing also did not differ after 24 months (mean difference, -0.029 [CI, -0.122 to 0.064]). Only 1 of the sensitivity analyses, based on extreme assumptions regarding missing assessments due to total hip replacement, provided results consistent with a glucosamine effect. LIMITATIONS: Twenty patients had total hip replacement during the trial. Half of the patients had a Kellgren and Lawrence score of 1. CONCLUSION: Glucosamine sulfate was no better than placebo in reducing symptoms and progression of hip osteoarthritis. International Standard Randomised Controlled Trial Number: ISRCTN54513166.


Subject(s)
Glucosamine/therapeutic use , Osteoarthritis, Hip/drug therapy , Administration, Oral , Aged , Arthroplasty, Replacement, Hip , Disease Progression , Double-Blind Method , Glucosamine/adverse effects , Hip Joint/pathology , Humans , Middle Aged , Osteoarthritis, Hip/pathology , Osteoarthritis, Hip/physiopathology , Pain/prevention & control , Sensitivity and Specificity
14.
Radiology ; 246(2): 420-5, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18227539

ABSTRACT

PURPOSE: To help guide future outcomes research regarding the use of magnetic resonance (MR) imaging in patients with acute knee trauma in an emergency department setting, with use of prospective data from a randomized clinical trial and value of information analysis. MATERIALS AND METHODS: A total of 189 patients (123 male, 66 female; mean age, 33.4 years) were randomly assigned to undergo radiography alone (n = 93) or radiography and MR imaging (n = 96). Institutional review board approval and informed consent (parental consent for minors) were obtained. During 6 months of follow-up, data on quality of life and 39 cost parameters were collected. Value-of-information analysis was used to estimate the expected benefit of future research to eliminate the decision uncertainty that remained after trial completion. In addition, the parameters that were responsible for most of the decision uncertainty were identified, the expected benefits of various study designs were evaluated, and the optimal sample size was estimated. RESULTS: Only three parameters were responsible for most of the decision uncertainty: number of quality-adjusted life-years, cost of an overnight hospital stay, and friction costs. A study in which data on these three parameters are gathered would have an optimal sample size of 3500 patients per arm and would be expected to result in a societal benefit of euro 5.6 million or 70 quality-adjusted life-years. CONCLUSION: The optimal study design for use of MR imaging to evaluate acute knee trauma involves a trial in which there are 3500 patients per trial arm, and data on the number of quality-adjusted life-years, cost of an overnight hospital stay, and friction costs are collected.


Subject(s)
Decision Support Techniques , Health Care Costs/statistics & numerical data , Knee Injuries/diagnosis , Knee Injuries/economics , Magnetic Resonance Imaging/economics , Magnetic Resonance Imaging/statistics & numerical data , Outcome Assessment, Health Care/methods , Quality of Life , Adolescent , Adult , Aged , Child , Cost Savings , Cost-Benefit Analysis , Female , Humans , Male , Middle Aged , United Kingdom/epidemiology
15.
Arch Orthop Trauma Surg ; 128(10): 1099-106, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18094984

ABSTRACT

INTRODUCTION: Extra-articular calcaneal fractures represent 25-40% of all calcaneal fractures and an even higher percentage of up to 60% is seen in children. A disproportionately small part of the literature on calcaneal fractures involves the extra-articular type. The aim of this study was to investigate the incidence of extra-articular calcaneal fractures in a Level 1 trauma centre, define the distribution of the various types of fractures and compare patient demographics between extra- and intra-articular calcaneal fractures. In addition the literature was reviewed for the most common types of extra-articular calcaneal fractures with regard to incidence, treatment and clinical outcome. METHODS: The radiological records between 2003 and 2005 were reviewed for intra- and extra-articular calcaneal fractures. Patient gender-distribution and age were compared. A literature search was conducted for the treatment of extra-articular calcaneal fractures. RESULTS: In this 3-year study period a total of 49 patients with 50 extra-articular calcaneal fractures and 91 patients with 101 intra-articular fractures were identified. The median age for the first group was 32.7 years, and for the second group 40.3 years; P = 0.04. Male predominance was significantly less pronounced for extra-articular (63%) compared with intra-articular fractures (79%; P = 0.04). CONCLUSION: One-third of all calcaneal fractures are extra-articular. Significant differences exist between the intra- and extra-articular groups, in terms of lower age and male-female ratio. The literature study shows inconsistencies in treatment options, but most extra-articular fractures are well manageable conservatively.


Subject(s)
Calcaneus/injuries , Fractures, Bone/epidemiology , Fractures, Bone/surgery , Adult , Calcaneus/diagnostic imaging , Female , Fractures, Bone/diagnostic imaging , Humans , Incidence , Male , Radiography , Treatment Outcome
17.
Semin Ultrasound CT MR ; 28(2): 141-57, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17432768

ABSTRACT

Magnetic resonance imaging (MRI) is a well-established technique for detecting internal derangements of the knee joint with high diagnostic accuracy. It is an effective tool to select patients for targeted therapeutic arthroscopy. In this article, indications for knee MRI and most commonly used MRI techniques are outlined, followed by an overview of the most frequently encountered traumatic knee derangements in daily practice and their appearance and grading system on MRI. Lesions discussed include fractures, osteochondral lesions, bone bruise, cruciate and collateral ligament lesions, and meniscal tears. Finally, common pitfalls and recent developments in knee MRI are addressed.


Subject(s)
Knee Injuries/pathology , Magnetic Resonance Imaging , Cartilage, Articular/injuries , Cartilage, Articular/pathology , Fractures, Cartilage/pathology , Humans , Image Processing, Computer-Assisted , Ligaments, Articular/injuries , Ligaments, Articular/pathology , Magnetic Resonance Imaging/methods , Magnetic Resonance Imaging/trends , Menisci, Tibial/pathology , Posture , Signal Processing, Computer-Assisted , Tibial Meniscus Injuries
18.
J Orthop Sci ; 12(1): 22-7, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17260113

ABSTRACT

BACKGROUND: The outcome after displaced intra-articular calcaneal fractures is influenced by the condition of the surrounding soft tissues. To avoid secondary soft tissue complications after surgical treatment, several less-invasive procedures for reduction and fixation have been introduced. The percutaneous technique according to Forgon and Zadravecz is suitable for all types of displaced intra-articular calcaneal fractures and was therefore introduced in our clinic. The aim of this study was to evaluate the long-term outcome of percutaneous treatment according to Forgon and Zadravecz in patients with displaced intra-articular calcaneal fractures. METHODS: A cohort of patients with displaced intra-articular calcaneal fractures treated with percutaneous surgery was retrospectively defined. Clinical outcome was evaluated by standardized physical examination, radiographs, three published outcome scores, and a visual analogue scale of patient satisfaction. RESULTS: Fifty patients with 61 calcaneal fractures were included. After a mean follow-up period of 35 months, the mean values of the Maryland foot score, the Creighton-Nebraska score, and the American Orthopaedic Foot and Ankle Society score were 79, 76, and 83 points out of 100, respectively. The average visual analogue scale was 7.2 points out of 10. The average range of motion of the ankle joint was 90% of normal and subtalar joint movements were almost 70% compared with the healthy side or normal values. Superficial wound complications occurred in seven cases (11%) and deep infections in two (3%). A secondary arthrodesis of the subtalar joint was performed in five patients and was scheduled in four patients (15%). CONCLUSIONS: Compared with the outcome of historic controls from randomized trials and meta-analyses, this study indicates favorable results for the percutaneous technique compared with the open technique. Despite similar rates of postoperative infection and secondary arthrodesis, the total outcome scores and preserved subtalar motion are overall good to excellent.


Subject(s)
Bone Screws , Calcaneus/injuries , Fracture Fixation, Internal/instrumentation , Fractures, Bone/surgery , Adolescent , Adult , Aged , Arthrodesis/methods , Calcaneus/diagnostic imaging , Calcaneus/surgery , Female , Fluoroscopy , Follow-Up Studies , Fractures, Bone/diagnostic imaging , Humans , Male , Middle Aged , Patient Satisfaction , Reoperation , Retrospective Studies , Surveys and Questionnaires , Time Factors , Trauma Severity Indices , Treatment Outcome
19.
Acta Orthop ; 77(3): 531-40, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16819696

ABSTRACT

BACKGROUND: Syndesmotic injuries of the ankle without fractures can result from external rotation, abduction and dorsiflexion injuries. Kinematic studies of these trauma mechanisms have not been performed. We attempted to describe the kinematics of the tibiofibular joint in cadaveric specimens using radiostereometry after sequential ligament sectioning, and resulting from different trauma mechanisms and axial loading, in order to put forward treatment guidelines for the different types of syndesmotic injuries. METHODS: We assessed the kinematics of the distal tibiofibular joint in fresh-frozen cadaveric specimens using radiostereometry in the intact situation, and after alternating and sequential sectioning of the distal tibiofibular and anterior deltoid ligaments. To assess which of the known trauma mechanisms would create the largest displacements at the syndesmosis, the ankle was brought into the following positions under an axial load that was comparable to body weight (750 N): neutral, dorsiflexion, external rotation, abduction, and a combination of external rotation and abduction. RESULTS: In the neutral position, the largest displacements of the fibula consisted of external rotation and posterior translation. Loading of the ankle with 750 N did not apparently increase or decrease the displacements of the fibula, but gave a larger variety of displacements. In every position, sectioning of a ligament resulted in some fibular displacement. Sectioning of the anterior tibiofibular ligament (ATiFL) invariably resulted in external rotation of the fibula. Additional sectioning of the anterior part of the deltoid ligament (AD) gave a larger variety of displacements. In general, sectioning of the posterior tibiofibular ligament (PTiFL) gave the smallest displacements. Combined sectioning of the ATiFL and the PTiFL resulted in a larger variety of displacements in the neutral position. Sectioning of the AD together with the ATiFL and PTiFL resulted in tibiofibular displacements in the neutral situation exceeding the maximum values found in the intact situation, the most important being fibular external rotation. INTERPRETATION: Sectioning of the ATiFL results in mechanical instability of the syndesmosis. Of all trauma mechanisms, external rotation of the ankle resulted in the largest and most consistent displacements of the fibula relative to the tibia found at the syndesmosis. Based on our findings and the current literature, we recommend that patients with isolated PTiFL or AD injuries should be treated functionally when no other injuries are present. Patients with acute complete ATiFL ruptures, or combined ATiFL and AD ruptures should be treated with immobilization in a plaster. Patients with combined ruptures of the ATiFL, AD and PTiFL need to be treated with a syndesmotic screw.


Subject(s)
Ankle Injuries/physiopathology , Fibula/physiopathology , Ligaments, Articular/physiopathology , Tibia/physiopathology , Aged , Aged, 80 and over , Ankle Injuries/surgery , Biomechanical Phenomena , Bone Screws , Cadaver , Humans , Joint Dislocations/physiopathology , Joint Instability/physiopathology , Models, Biological , Range of Motion, Articular/physiology , Rotation , Weight-Bearing/physiology
20.
Radiology ; 236(3): 958-67, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16118171

ABSTRACT

PURPOSE: To assess prospectively if a short imaging examination performed with low-field-strength dedicated magnetic resonance (MR) imaging in addition to radiography is effective and cost saving compared with the current diagnostic imaging strategy (radiography alone) in patients with recent acute traumatic injury of the wrist, knee, or ankle. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. Patients with recent trauma of the wrist, knee, or ankle were randomized across two diagnostic strategies: radiography alone (reference group) or radiography followed by a short MR imaging examination (intervention group). Measures of effectiveness included the number of additional diagnostic procedures, time to last diagnostic procedure, and number of days absent from work. Measures of effectiveness were analyzed by using an exact Wilcoxon-Mann-Whitney test. Time to convalescence and quality of life were analyzed by using a t test. Cost analysis was performed from a societal perspective and analyzed by using a t test. RESULTS: Five hundred patients (207 women, 293 men; mean age, 34.8 years) with acute injury of the wrist, knee, or ankle were randomized. In the intervention group, quality of life for patients with knee injuries was significantly higher during the first 6 weeks, and time to completion of diagnostic work-up was significantly shorter (mean, 3.5 days for intervention group vs 17.3 days for reference group). The number of additional diagnostic procedures was significantly lower in the intervention group versus the reference group (nine vs 35, respectively) for patients with knee injuries. Patients with knee injuries showed the largest difference in costs (intervention group, 1820 [$1966]; reference group, 2231 [$2409]) owing to a reduction in productivity loss. Costs were higher in patients with wrist injuries and almost equal in patients with ankle injuries. All cost differences, however, were not significant. CONCLUSION: Compared with radiography, MR imaging in patients with acute wrist or ankle injuries is neither cost saving nor effective in expediting diagnostic work-up or improving quality of life. In patients with knee injuries, a short MR imaging examination shortens the time to completion of diagnostic work-up, reduces the number of additional diagnostic procedures, improves quality of life in the first 6 weeks, and may reduce costs associated with lost productivity.


Subject(s)
Ankle Injuries/diagnosis , Cost-Benefit Analysis , Knee Injuries/diagnosis , Magnetic Resonance Imaging/economics , Wrist Injuries/diagnosis , Adult , Ankle Injuries/diagnostic imaging , Chi-Square Distribution , Cost Savings , Costs and Cost Analysis , Female , Humans , Knee Injuries/diagnostic imaging , Male , Prospective Studies , Quality of Life , Radiography , Statistics, Nonparametric , Wrist Injuries/diagnostic imaging
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