ABSTRACT
A 1.5 yr old male German shepherd dog was evaluated for recurrent intermittent episodes of fever and lethargy. Clinicopathologic abnormalities were suggestive of a discospondylitis at the seventh and eighth thoracic vertebrae. Blood and urine cultures yielded growth of methicillin-resistant Staphylococcus pseudintermedius (MRSP) that was resistant to all commonly used antibiotics. Extralabel antibiotic susceptibility testing demonstrated susceptibility of both blood and urine isolates to linezolid. The prescribed dose was extrapolated from pharmacokinetic (PK) studies and the isolate's plasma minimum inhibitory concentration (MIC). Linezolid was administered for 23 wk and resulted in successful resolution of bacteremia, bacteriuria, and discospondylitis. When justified, linezolid should be considered to treat methicillin-resistant infections.
Subject(s)
Acetamides/therapeutic use , Anti-Infective Agents/therapeutic use , Dog Diseases/drug therapy , Oxazolidinones/therapeutic use , Spondylitis/veterinary , Staphylococcal Infections/veterinary , Acetamides/administration & dosage , Animals , Anti-Infective Agents/administration & dosage , Dog Diseases/microbiology , Dogs , Fever/veterinary , Linezolid , Male , Methicillin Resistance , Microbial Sensitivity Tests/veterinary , Oxazolidinones/administration & dosage , Spondylitis/diagnosis , Staphylococcal Infections/diagnosis , Staphylococcus/isolation & purification , Thoracic VertebraeABSTRACT
A 4 yr old spayed female Labrador retriever was examined 4 hr after ingesting an overdose of phenylpropanolamine (PPA). Clinical signs included anxiety, piloerection, mucosal ulceration, cardiac arrhythmia, mydriasis, and hyphema. Clinicopathologic abnormalities included elevated creatine kinase (CK) and aspartate aminotransferase (AST), proteinuria, and pigmenturia. Ventricular tachycardia and severe systemic hypertension were documented. Hyphema and retinal detachment were documented oculus uterque (OU). Phenoxybenzamine, sotalol, and esmolol resolved the ventricular tachycardia, and blood pressure was controlled with nitroprusside. All clinicopathologic and cardiac abnormalities resolved within 7 days, and ocular changes resolved within 1 mo. Monitoring of blood pressure and rapid pharmacologic intervention were successful in controlling hypertension secondary to PPA overdose and minimizing retinal damage.
Subject(s)
Dog Diseases/chemically induced , Hypertension/veterinary , Hypertensive Retinopathy/veterinary , Phenylpropanolamine/toxicity , Sympathomimetics/toxicity , Animals , Dog Diseases/therapy , Dogs , Drug Overdose/veterinary , Female , Hypertension/chemically induced , Hypertension/therapy , Hypertensive Retinopathy/chemically induced , Hypertensive Retinopathy/therapy , Phenylpropanolamine/administration & dosage , Retinal Detachment/chemically induced , Retinal Detachment/therapy , Retinal Detachment/veterinary , Sympathomimetics/administration & dosage , Treatment OutcomeABSTRACT
This retrospective study reports the presence and incidence of nasal turbinates in the nasopharynx (nasopharyngeal turbinates) in a population of brachycephalic dogs and cats exhibiting signs of upper respiratory disease. Medical records were reviewed for 53 brachycephalic dogs and 10 brachycephalic cats undergoing upper airway endoscopy. Nasopharyngeal turbinates were identified in 21% of brachycephalic animals, including 21% of dogs and 20% of cats. Pugs accounted for 32% of all dogs in the study population and 82% of dogs with nasopharyngeal turbinates. The presence of nasopharyngeal turbinates may play a role in upper airway obstruction in the brachycephalic airway syndrome.