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1.
Am J Dermatopathol ; 43(9): 659-661, 2021 Sep 01.
Article in English | MEDLINE | ID: mdl-33606372

ABSTRACT

ABSTRACT: Although not a diagnostic criterion for basal cell nevus syndrome (BCNS, OMIM#109400), cutaneous cysts, particularly epidermoid cysts, are common in this condition. Cutaneous keratocysts, on the other hand, are extremely rare in general and have been identified in only 5 patients with BCNS. Here, we describe a BCNS patient with a cutaneous keratocyst that demonstrated D2-40 (podoplanin) immunoreactivity, which has been detected in odontogenic keratocysts but not cutaneous keratocysts. This finding suggests that cutaneous keratocysts may be developmentally homologous to odontogenic keratocysts and may behave similarly in terms of invasion and growth pattern.


Subject(s)
Basal Cell Nevus Syndrome/metabolism , Epidermal Cyst/metabolism , Membrane Glycoproteins/metabolism , Skin Neoplasms/metabolism , Antibodies, Monoclonal, Murine-Derived , Basal Cell Nevus Syndrome/pathology , Child , Female , Humans , Odontogenic Cysts/metabolism , Skin Neoplasms/pathology
2.
Altern Ther Health Med ; 27(4): 41-49, 2021 Jul.
Article in English | MEDLINE | ID: mdl-33245705

ABSTRACT

BACKGROUND: Vitamins and their derivatives are used extensively in the field of dermatology to treat a range of conditions, both benign and malignant. Additionally, over the past decade, vitamin supplements have been heavily advertised for improving overall health. Due to the widespread use of vitamins and their derivatives for dermatologic conditions, a comprehensive review of the evidence is needed. OBJECTIVE: Here we review several of the well-established uses of vitamins A, B, C, and D in the management of dermatologic conditions ranging from acne vulgaris to malignant melanoma. Additionally, we examine the dermatologic consequences of both deficiency and excess of vitamins A, B, C, and D. Finally, we delve into newer applications for these vitamins and evaluate the evidence behind them. CONCLUSION: Vitamins, in both topical and oral forms, play a key role in treating many dermatologic conditions. Some of the newer applications of vitamins, such as the use of vitamin B3 for non-melanoma skin cancer prevention, vitamin B6 for prevention of chemotherapy-induced alopecia, and vitamin C as an adjuvant treatment for malignant melanoma, appear promising. Further data is needed to validate these findings. Additionally, many people use vitamin B7 for hair, skin, and nail health. There is evidence that supports vitamin B7 supplementation in patients with uncombable hair syndrome, brittle nail syndrome, and seborrheic dermatitis. Some studies Some studies have also demonstrated a benefit in healthy individuals, although other studies have shown a neutral effect. Further randomized controlled trials are needed. Likewise, the use of vitamin D for the treatment of atopic dermatitis has conflicting results and requires further investigation. New research continues to emerge regarding vitamin supplementation, and it is an important topic for dermatologists.


Subject(s)
Dermatologists , Vitamins , Ascorbic Acid , Dietary Supplements , Humans , Vitamin A/therapeutic use , Vitamin D , Vitamins/therapeutic use
4.
Article in English | MEDLINE | ID: mdl-31233172

ABSTRACT

Hyperbaric oxygen therapy (HBOT) is used in the management of a wide array of disease states, including acute thermal burn injuries, carbon monoxide poisoning, and decompression sickness, to name a few. Although HBOT is approved by the Undersea and Hyperbaric Medical Society for the treatment of only 14 conditions, it has been used "off-label" in the management of a variety of dermatological diseases. This review investigates the utilization of HBOT in dermatology and appraises the evidence behind its use. We focus on the role of HBOT in treating necrotizing soft tissue infections, compromised grafts and flaps, hidradenitis suppurativa, and pyoderma gangrenosum.


Subject(s)
Hidradenitis Suppurativa/therapy , Hyperbaric Oxygenation/methods , Pyoderma Gangrenosum/therapy , Soft Tissue Infections/therapy , Fasciitis, Necrotizing/therapy , Humans
7.
Int J Dermatol ; 58(8): 865-870, 2019 Aug.
Article in English | MEDLINE | ID: mdl-30479009

ABSTRACT

Electrochemotherapy (ECT) is a treatment modality that combines low-dose chemotherapy with electroporation, thereby enhancing cytotoxicity. ECT was first utilized in the treatment of metastatic head and neck cancer. Today it is used as a local treatment for the cutaneous and subcutaneous metastases of a variety of cancers, including melanoma. In addition, recent evidence indicates that ECT in combination with immunotherapy can lead to a systemic tumor response. This review aims to summarize the efficacy of ECT in the treatment of metastatic melanoma, with a specific focus on the combination of ECT with immunotherapy.


Subject(s)
Antineoplastic Agents, Immunological/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Electrochemotherapy/methods , Melanoma/drug therapy , Skin Neoplasms/drug therapy , Antineoplastic Agents, Immunological/adverse effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Clinical Trials as Topic , Electrochemotherapy/adverse effects , Humans , Melanoma/pathology , Skin Neoplasms/pathology , Treatment Outcome
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