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1.
Oral Dis ; 22(6): 573-7, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27128209

ABSTRACT

OBJECTIVE: Recurrent aphtous stomatitis (RAS) is an inflammatory oral mucosal disease. It has been known that inflammatory cascade plays important role in the atherosclerotic process. The aim of the study was to investigate the relationship between subclinical atherosclerotic findings and a systemic inflammatory disease, RAS. METHODS: In total, 32 patients with RAS were matched with 30 control subjects on the basis of age, sex, and major cardiovascular risk factors. Laboratory parameters including lipid profiles were determined for patients and controls. B-mode ultrasonography was used to assess carotid extra-medial thickness (cEMT) and carotid intima-media thickness (cIMT). RESULTS: Both cEMT and cIMT in the RAS group were significantly higher than in the control group (P = 0.002 and 0.013, respectively). There was a significant positive correlation between cIMT and cEMT (r = 0.381, P = 0.034). cIMT was positively correlated with age, triglyceride levels, and systolic blood pressure, while cEMT was positively correlated with age in patients with RAS. CONCLUSIONS: To our knowledge, this is the first reported study to evaluate cEMT and cIMT in patients with RAS. This study presents morphological evidence of subclinical atherosclerosis in patients with RAS. Further studies investigating the relationship between atherosclerosis and RAS are needed.


Subject(s)
Atherosclerosis/complications , Stomatitis, Aphthous/complications , Carotid Arteries/pathology , Humans
2.
Clin Ter ; 165(1): e59-63, 2014.
Article in English | MEDLINE | ID: mdl-24589962

ABSTRACT

AIMS: To determine the prevalence of asthma, asthma-like symptoms and allergic diseases among adults 30-49 years of age in regions of Bolu. MATERIALS AND METHODS: A questionnaire was given to families of students in schools in different areas of Bolu, Turkey. The European Community Respiratory Health Survey (ECRHS) and a questionnaire, including questions about the socioeconomic status and demographic characteristics of the participants, were responded to by 1403 people. RESULTS: The prevalence of symptoms and diseases were as follows: wheezing in the last year 12.0% (n=168), asthma 8.7% (n=121), doctor-diagnosed asthma 3.6% (n=50), currently taking drugs for asthma 1.2% (n=17), allergic rhinitis 16.5% (n=230), and eczema 9.6% (n=134). The risk factors for each symptom or disease were as follows: for wheezing: smoking in the house (odds ratio [OR]=2.43 and 95% Confidence Limits [95%CL]=1.53-3.86), living in a non-concrete building (OR=2.17, 95%CL=1.27-3.69); for asthma: mold in the house (OR=1.70, 95% CL=1.05-2.76), living in a shanty (OR=2.76, 95%CL=1.30-5.85), smoking in the house (OR=1.51, 95%CL=1.02-2.22); for allergic rhinitis: being female (OR=1.55, 95%CL=1.08-2.24), living in a shanty (OR=5.81, 95%CL=2.06-16.39), a monthly income below $300 (OR = 1.74, 95%CL=1.13-2.69). CONCLUSIONS: A high rate of undiagnosed and untreated people with asthma among adults 30-49 years of age is present in Bolu. Especially, while a low socioeconomic level was observed to increase the risk of asthma and allergic rhinitis, risk of wheeze and asthma was found to be elevated by smoking in house.


Subject(s)
Asthma/epidemiology , Eczema/epidemiology , Smoking/epidemiology , Adult , Black Sea , Female , Humans , Male , Middle Aged , Prevalence , Risk Factors , Surveys and Questionnaires , Turkey/epidemiology
5.
Clin Exp Dermatol ; 31(3): 398-400, 2006 May.
Article in English | MEDLINE | ID: mdl-16681587

ABSTRACT

Candida species rarely cause black pigmentation of infected nails and only a few cases have been reported in the literature. We describe a 53-year-old white man who had diffuse melanonychia of the fourth right fingernail due to C. albicans. A progressive dark pigmentation of his nail appeared over 6 months, following paronychial inflammation. The melanonychia was associated with brittleness. There was no onycholysis or hyperkeratosis. Direct examination with potassium hydroxide demonstrated round yeast cells in the specimen. The samples were cultured on Sabouraud glucose agar containing chloramphenicol at 27 degrees C and showed white growth after a few days. The patient was successfully treated with systemic itraconazole.


Subject(s)
Candida albicans , Melanosis/microbiology , Onychomycosis/microbiology , Antifungal Agents/therapeutic use , Candida albicans/isolation & purification , Hand Dermatoses/drug therapy , Hand Dermatoses/microbiology , Humans , Itraconazole/therapeutic use , Male , Onychomycosis/drug therapy , Treatment Outcome
6.
J Eur Acad Dermatol Venereol ; 18(4): 455-8, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15196161

ABSTRACT

BACKGROUND: The treatment of viral warts remains challenging. A variety of treatment modalities have been used with a range of success. Fluorouracil has been shown to be effective in treating warts but the method of its delivery directly onto the affected tissue has been of little efficacy. We evaluated the safety and efficacy of intralesional 5-fluorouracil in the treatment of verrucae. METHODS: Seventy-six patients with a total 315 verrucae were randomized to receive either a 5-fluorouracil, lidocaine and epinephrine (5-FU + LE) mixture or serum saline injection into the paired verrucae in the same patient. The mixture of 5-FU (4 cm(3), 50 mg/mL), lidocaine (1 cm(3), 20 mg/mL) and epinephrine (0.0125 mg/mL) was injected into the base of the wart using a mantoux needle. Each lesion was infiltrated with either of the solutions once a week for up to a maximum of 4 weeks, and the patients were followed up for 6 months. RESULTS: Complete response was noted in an average of 70% of the verrucae treated with the 5-FU + LE mixture and in 29% of those in the placebo group (P < 0.001). No clinically significant systemic and local adverse effects occurred. Pain and burning were noted as an immediate injection pain. Recurrence rates were evaluated and no statistically significant difference between the two groups was found. CONCLUSIONS: The results demonstrate that treatment of verrucae with 5-FU + LE mixture is safe and effective.


Subject(s)
Anesthetics, Local/administration & dosage , Antimetabolites/administration & dosage , Epinephrine/administration & dosage , Fluorouracil/administration & dosage , Lidocaine/administration & dosage , Vasoconstrictor Agents/administration & dosage , Warts/drug therapy , Adolescent , Adult , Drug Combinations , Humans , Injections, Intralesional , Middle Aged , Recurrence , Single-Blind Method
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