ABSTRACT
Thirty-nine volunteer students from 3 health science colleges at Touro University California participated in an exercise designed to promote interprofessional collaboration. In the event, thirteen 3-person multidisciplinary teams of students identified potential medical errors in a series of case-based scenarios. In an immediate postevent survey, 33 of 39 respondents (85%) indicated that the exercise marked the first time that they had worked on clinical problems with students from other health professions. All respondents agreed that interprofessional education was useful and necessary. A 6-month follow-up survey had 24 respondents, 9 of whom (38%) indicated that the experience helped them in interprofessional communications in their clinical rotations. Twenty-two respondents (92%) recalled that all team members were involved in the selection of answers. Respondents reported that team answer selections were made by consensus (12 [50%]), by accepting the opinion of an "expert" on the team (9 [38%]), or by majority vote (3 [13%]). Since this exercise, there has been a surge of interprofessional activities at Touro University California, including steps toward the implementation of campus-wide interprofessional education.
Subject(s)
Interprofessional Relations , Medical Errors/prevention & control , Osteopathic Medicine/education , Patient Care Team/organization & administration , Pharmacy , Physician Assistants/education , California , Clinical Competence , Cooperative Behavior , Health Care Surveys , Health Personnel/education , Humans , Osteopathic Medicine/standards , Patient Care Team/standards , Risk FactorsABSTRACT
OBJECTIVES: To create a valid assessment tool to evaluate the readiness of pharmacy students for advanced pharmacy practice experiences (APPEs). DESIGN: The Triple Jump Examination (TJE) was tailored to the 4-year, 2-plus-2 curriculum of the College. It consisted of (1) a written, case-based, closed-book examination, (2) a written, case-based open-book examination, and (3) an objective structured clinical examination (OSCE). The TJE was administered at the end of each 4 academic semesters. Progression of students to APPEs was dependent on achieving a preset minimum cumulative (weighted average) score in the 4 consecutive TJE examinations. ASSESSMENT: The predictive utility of the examination was demonstrated by a strong correlation between the cumulative TJE scores and the preceptor grades in the first year (P3) of APPEs (r = 0.60, p > 0.0001). Reliability of the TJE was shown by strong correlations among the 4 successive TJE examinations. A survey probing the usefulness of TJE indicated acceptance by both students and faculty members. CONCLUSION: The TJE program is an effective tool for the assessment of pharmacy students' readiness for the experiential years. In addition, the TJE provides guidance for students to achieve preparedness for APPE.
Subject(s)
Clinical Competence , Competency-Based Education/methods , Educational Measurement/methods , Internship, Nonmedical , Students, Pharmacy , Data Collection , Education, Pharmacy/methods , HumansABSTRACT
Alterations in Ca(2+) homeostasis and accumulation of unfolded proteins in the endoplasmic reticulum (ER) lead to an ER stress response. Prolonged ER stress may lead to cell death. Glucose-regulated protein (GRP) 78 (Bip) is an ER lumen protein whose expression is induced during ER stress. GRP78 is involved in polypeptide translocation across the ER membrane, and also acts as an apoptotic regulator by protecting the host cell against ER stress-induced cell death, although the mechanism by which GRP78 exerts its cytoprotective effect is not understood. The present study was carried out to determine whether one of the mechanisms of cell death inhibition by GRP78 involves inhibition of caspase activation. Our studies indicate that treatment of cells with ER stress inducers causes GRP78 to redistribute from the ER lumen with subpopulations existing in the cytosol and as an ER transmembrane protein. GRP78 inhibits cytochrome c-mediated caspase activation in a cell-free system, and expression of GRP78 blocks both caspase activation and caspase-mediated cell death. GRP78 forms a complex with caspase-7 and -12 and prevents release of caspase-12 from the ER. Addition of (d)ATP dissociates this complex and may facilitate movement of caspase-12 into the cytoplasm to set in motion the cytosolic component of the ER stress-induced apoptotic cascade. These results define a novel protective role for GRP78 in preventing ER stress-induced cell death.