Age-dependent memory impairment induced by co-exposure to nicotine and a synthetic cannabinoid in mice.

Co-use of marijuana and tobacco products is the second most common drug combination among adolescents. Nicotine (NIC) and cannabinoid use during adolescence induce similar detrimental changes, raising the hypothesis that simultaneous exposure could result in even more severe outcomes. Thus, we investigated whether the co-exposure to NIC and the synthetic cannabinoid WIN 55,212-2 (WIN) in adolescent mice causes behavioral outcomes different from those observed after exposure to a single drug. Male Swiss mice were exposed twice daily to NIC, WIN, or NIC + WIN during adolescence (PND28-47) or adulthood (PND70-89). Drug combination led to a greater reduction in weight gain in adolescent mice, while NIC-induced weight loss was observed in adults. During administration, NIC provoked hypothermia, and WIN produced hyperlocomotion in adolescent and adult mice. Animals exposed to NIC + WIN presented a profile of changes similar to those exposed to NIC. After drug exposure, changes in locomotion, thigmotaxis, social preference, prepulse inhibition, and working and recognition memory were evaluated. Adolescent but not adult mice exposed to NIC showed withdrawal-related hyperlocomotion unaffected by WIN co-administration. An age-specific impairment in object recognition memory was induced only by drug co-exposure during adolescence, which resolved spontaneously before reaching early adulthood. A transient decrease in hippocampal α7 nAChR subunit and CB1 receptor mRNA levels was induced by NIC exposure, which may be involved but is not enough to explain the memory impairment. Our work confirms the potential of NIC and cannabinoids association to aggravate some of the individual drug effects during critical neurodevelopmental periods.

Counselling treatment versus counselling associated with jaw exercises in patients with disc displacement with reduction-a single-blinded, randomized, controlled clinical trial.

OBJECTIVE: To compare effectiveness of counselling program versus counselling program plus jaw exercises to reduce pain and click in patients with temporomandibular joint disc displacement with reduction (DDWR). MATERIALS AND METHODS: Patients were divided into two groups: instructions for temporomandibular disorders (TMD) plus jaw exercises (test, n = 34), only TMD instructions (control, n = 34). Pain was analyzed by palpation (RDC/TMD). It was investigated if the click caused discomfort. Both groups were evaluated at baseline, 24 h, 7 days, and 30 days' post treatment. RESULTS: The click was present in 85.7% (n = 60). In 30-day evaluation, there was a statistically significant difference between groups in the right median temporal muscle (p = 0.041); and there was a statistically significant difference in treatment self-perception (p = 0.002) and click's discomfort (p < 0.001). CONCLUSION: The exercise with recommendations showed better results, resolution of the click, and self-perception of the treatment effectiveness. CLINICAL RELEVANCE: This study presents therapeutic approaches that are easy to perform and that can be monitored remotely. In view of the current stage of the global pandemic, these treatment options become even more valid and useful. CLINICAL TRIAL REGISTER: This clinical trial was registered at Brazilian Clinical Trials Registry (ReBec) under protocol RBR-7t6ycp ( http://www.ensaiosclinicos.gov.br/rg/RBR-7t6ycp/ ), Date of registration: 26/06/2020.

Educational Technology on Urinary Incontinence during Pregnancy: Development and Validation of an Online Course for the Brazilian Population / Tecnologia educacional sobre incontinência urinária gestacional: desenvolvimento e validação de curso on-line para o Brasil / Tecnología educativa sobre incontinencia urinaria durante el embarazo: desarrollo y validación de un curso en línea para Brasil

Objective: To describe the development and validation process of an online course on urinary incontinence during pregnancy in Brazil. Materials and methods: This methodological study followed an online course's literature search, development, and validation steps. A total of 22 specialists participated in the validation step, and the content validity index (CVI) was used. Fifty-one Physical Therapy students (target audience) also participated in the Suitability Assessment of Materials. Results: The synthesis reached in the integrative review provided the basis for the course's theoretical content, which was regarded as suitable by the specialists regarding its content, language, presentation, stimulation/motivation, and cultural adequacy (CVI = 0.99). The target audience considered the course organized, easily understandable, engaging, and motivational, with a positive response index ranging from 84.3 % to 100 %. Conclusions: The Brazilian version of the online course was considered sufficiently adequate in content and interface quality by both specialists and the target audience.

Objetivo: descrever o processo de desenvolvimento e validação de um curso on-line sobre incontinência urinária gestacional no Brasil. Materiais e método: trata-se de um estudo metodológico que contemplou as etapas de levantamento bibliográfico, elaboração e validação de um curso on-line. A validação teve a participação de 22 especialistas e foi empregado o índice de validade de conteúdo (IVC). Também participaram 51 estudantes de graduação em Fisioterapia (público-alvo), considerando o Suitability Assessment of Materials. Resultados: a síntese adquirida na revisão integrativa subsidiou o conteúdo teórico do curso, considerado adequado pelos especialistas quanto ao conteúdo, à linguagem, à apresentação, à estimulação/motivação e à adequação cultural (IVC = 0,99), bem como à aparência/interface (IVC = 0,95). O público-alvo considerou o curso organizado, de fácil entendimento, atrativo e motivador, com índice de concordância em repostas positivas a variar de 84,3 % a 100 %. Conclusões: informa-se que a versão brasileira do curso on-line desenvolvido foi considerada suficientemente adequada em termos de conteúdo e qualidade da interface, tanto pelos especialistas quanto pelo público-alvo.

Objetivo: describir el proceso de desarrollo y validación de un curso en línea sobre incontinencia urinaria durante el embarazo en Brasil. Materiales y método: se trata de un estudio metodológico que contempló las etapas de recolección bibliográfica, elaboración y validación de un curso en línea. La validación contó con la participación de 22 expertos y se empleó el índice de validación de contenido (IVC). Además, participaron 51 estudiantes del pregrado en Fisioterapia (público objetivo) en la Evaluación de Idoneidad de los Materiales. Resultados: la síntesis adquirida en la revisión integrativa fundamentó el contenido teórico del curso, considerado adecuado por los expertos en cuanto al contenido, el lenguaje, la presentación, la estimulación/motivación y la adecuación cultural (IVC = 0,99), así como la apariencia/interfaz (IVC = 0,95). El público objetivo consideró el curso organizado, de fácil entendimiento, atractivo y motivador, con un índice de concordancia en respuestas positivas entre 84,3 % y 100 %. Conclusiones: la versión brasileña del curso en línea desarrollado se consideró lo suficientemente adecuada en términos de contenido y calidad de la interfaz, tanto por parte de los expertos como del público objetivo.

Práticas preventivas realizadas pelo enfermeiro da equipe de saúde da família relacionadas as úlceras em membros inferiores no cuidado às pessoas com diabetes mellitus / Preventive practices carried out by the nurse of the family health team related to lower limb ulcers in the care of people with diabetes mellitus

Dentre as Doenças Crônicas não Transmissíveis (DCNT), o Diabetes Mellitus (DM) se destaca por sua constante ascensão e taxas de morbimortalidade e aos altos custos sociais, econômicos e psicológicos. Ainda, quando não controlado o DM, propicia o desenvolvimento de complicações altamente incapacitantes, destacando-se as úlceras ou infecções em membros inferiores o que conhecemos como "pé diabético". O objetivo do estudo foi identificar as ações preventivas para úlceras ou infecções em membros inferiores em pessoas com diabetes mellitus realizadas pelos enfermeiros nas equipes de Saúde da Família. Além disso, realizar um produto tecnológico como elaborar um roteiro de rastreamento para úlceras ou infecções em membros inferiores para as pessoas com diabetes mellitus. Pesquisa de abordagem qualitativa realizada com 24 enfermeiros de equipes de saúde da família (eSF) do município de Passos - Minas Gerais. Foram incluídos no estudo os enfermeiros que atuam diretamente na assistência por mais de seis meses e excluídos aqueles que estivessem em cargo de gestão, de férias ou afastados por algum motivo. As entrevistas foram realizadas nas unidades de saúde por meio de um roteiro de perguntas para identificação de conhecimentos acerca da temática. As entrevistas foram audiogravadas e transcritas e analisadas pela técnica de análise temática e discutidas pela literatura científica. Dos 24 enfermeiros que atuam nas eSF, 12,5% eram do sexo masculino e 87,5% do sexo feminino. Apenas 16,6% dos entrevistados possuíam curso sobre o cuidado para pessoa com DM e apresentaram conhecimento limitado sobre a temática das úlceras ou infecções de membros inferiores. As ações de cuidado voltam-se para o controle glicêmico e avaliação da medicação para atendimento do hiperdia. Em relação as práticas preventivas as orientações realizadas versam sobre os cuidados gerais de higiene, uso de calçados, corte das unhas e tratamento local de feridas. Pouco se realiza na consulta de enfermagem a avaliação clínica para o risco de úlceras ou infecções em membros inferiores. Acerca dos recursos que o município dispõe para o atendimento à pessoa com úlceras ou infecções em membros inferiores evidencia-se que o município não dispõe de uma local de referência para o tratamento da diabetes e que o serviço especializado é bastante demorado e falta recursos humanos e materiais. Portanto, destaca-se a necessidade da promoção da educação continuada e permanente como ferramenta para que possa ter conhecimentos e habilidades, bem como, discutir sobre o processo de trabalho para proporcionar cuidados efetivos com conhecimento baseado em evidências. Além disso, é preciso investimentos para qualificar a consulta de enfermagem à pessoa com DM e as práticas preventivas, especialmente, as voltadas para o risco de desenvolvimento de úlceras ou infecções em membros inferiores. No intuito de colaborar para a melhoria das práticas preventivas e identificação de risco no processo de trabalho dos enfermeiros, foi elaborado um roteiro de rastreamento para úlceras ou infecções em membros inferiores para que os enfermeiros possam utilizar nas consultas às pessoas com DM

Among Chronic Noncommunicable Diseases (NCDs), Diabetes Mellitus (DM) stands out for its constant rise and morbidity and mortality rates and the high social, economic and psychological costs. Still, when DM is not controlled, it favors the development of highly disabling complications, especially ulcers or infections in the lower limbs, what we know as "diabetic foot". The objective of the study was to identify preventive actions for ulcers or infections in the lower limbs in people with diabetes mellitus carried out by nurses in the Family Health teams. In addition, making a technological product such as developing a screening script for ulcers or infections in the lower limbs for people with diabetes mellitus. Qualitative research carried out with 24 nurses from family health teams (eSF) in the city of Passos - Minas Gerais. Nurses who work directly in care for more than six months were included in the study, and those who were in management positions, on vacation or on leave for some reason were excluded. The interviews were carried out in the health units through a script of questions to identify knowledge about the theme. The interviews were audio-recorded and transcribed and analyzed using the thematic analysis technique and discussed in the scientific literature. Of the 24 nurses working in the eSF, 12.5% were male and 87.5% were female. Only 16.6% of respondents had taken a course on care for people with DM and had limited knowledge on the subject of ulcers or lower limb infections. Care actions focus on glycemic control and assessment of medication for hyperdia treatment. Regarding preventive practices, the guidelines provided deal with general hygiene care, use of shoes, nail trimming and local treatment of wounds. Little is done in the nursing consultation regarding the clinical assessment of the risk of ulcers or infections in the lower limbs. Regarding the resources that the municipality has for the care of people with ulcers or infections in the lower limbs, it is evident that the municipality does not have a reference place for the treatment of diabetes and that the specialized service is quite time consuming and lacks human resources and materials. Therefore, there is a need to promote continuing and permanent education as a tool to acquire knowledge and skills, as well as to discuss the work process to provide effective care with evidence-based knowledge. In addition, investments are needed to qualify the nursing consultation for people with DM and preventive practices, especially those aimed at the risk of developing ulcers or infections in the lower limbs In order to contribute to the improvement of preventive practices and risk identification in the work process of nurses, a screening script for ulcers or infections in the lower limbs was elaborated so that nurses can use it in consultations with people with DM

Development of a Clinical Data Model Addressing the Nursing Focus "Anxiety": A Consensus Development Study.

Anxiety disorders are among the most prevalent mental disorders worldwide. However, anxiety is not exclusive to anxiety disorders. In fact, the nursing discipline approaches anxiety as a human response to health conditions/life processes. Health information systems should primarily contribute to improving the quality of care, patient safety, and the effectiveness of care delivery. Nevertheless, nursing information systems still fail to incorporate evidence-based clinical data models addressing the nursing focus "anxiety." Thus, this study aimed to obtain consensus on the data to be included in a clinical data model addressing the nursing focus "anxiety," its organization, and its interrelationships by using a brainstorming session and a modified e-Delphi technique with a panel of nurse experts from across Portugal. Eight experts participated in the brainstorming session. A total of 59 and 54 participants completed the survey in e-Delphi rounds 1 and 2, respectively. Consensus was achieved to all data presented to the participants, and these data were later included in the clinical data model. This evidence-based clinical data model, grounded on a nursing theory and with standardized nursing language, will substantially contribute to nursing documentation and, consequently, to nursing care targeted at patients with anxiety.

Protective and Vulnerability Factors of Municipal Workers' Mental Health: A Cross-Sectional Study.

Work is fundamental to an individual's mental health; however, an unfavourable work environment can lead to mental health problems. Despite existing studies addressing workers' mental health, it is essential to understand the reality of specific contexts to design effective tailored interventions. Thus, this study aimed to examine the influence of potential protective and vulnerability factors on municipal workers' depressive symptoms, anxiety and stress levels, and burnout. A cross-sectional study was conducted with data collection performed between July and December 2021 using online self-report measures. The sample comprised 115 municipal workers. The findings revealed that psychological vulnerability is a significant vulnerability factor for the presence of mental health symptoms. In addition, job satisfaction was found to be a significant protective factor for depressive symptoms, anxiety, and burnout of the municipal workers. The results of this study enhance the understanding of factors that influence worker mental health, which may facilitate the proper planning of specific interventions to promote mental health in the workplace.

Análise de custo-efetividade do uso de inibidores da via de sinalização mTOR x micofenolato em receptores de transplante renal sem profilaxia para citomegalovírus s / Cost-effectiveness analysis of the use of mTOR signaling pathway inhibitors x mycophenolate in kidney transplantation recipients without cytomegalovirus prophylaxis

Objetivo: Avaliar a relação de custo-efetividade dos regimes imunossupressores utilizados em pacientes receptores de transplante renal, no Hospital Santa Casa de Misericórdia de Juiz de Fora, MG, basiliximabe, micofenolato de sódio, tacrolimo e prednisona (Grupo 1 = 93 pacientes), comparados com a associação de timoglobulina, everolimo, tacrolimo e prednisona (Grupo 2 = 91 pacientes). Métodos: Para a análise farmacoeconômica, foi utilizado o modelo de Árvore de Decisão, desenvolvido no software Treeage Suite 2011. Foi considerada uma coorte real de pacientes submetidos ao transplante renal entre janeiro de 2013 e março de 2017, os quais foram acompanhados por um período de um ano, sendo mensurados os benefícios clínicos, bem como os custos associados, na perspectiva do Sistema Único de Saúde. O método de custeio utilizado foi o botton-up. Foram adotados os limiares de custo-efetividade (LCEs) equivalentes a 1 PIB per capita e 1 a 3 PIB, considerando o ano de 2017. Resultados: No que diz respeito à sobrevida, a RCEI foi de cerca de R$ 214.234,12 para 1 ano de vida ganho. Em relação aos eventos adversos, a RCEI foi de cerca de R$ 43.682,98 para 1 ano sem incidência de eventos adversos. Conclusões: Ao avaliar a sobrevida e a incidência de eventos adversos, timoglobulina+everolimo não é considerado custo-efetivo em relação ao esquema contendo basiliximabe+micofenolato de sódio diante do LCE de 1 PIB per capita. No entanto, ao adotarmos o LCE até 3 PIB per capita, o regime contendo moglobulina+everolimo é custo-efetivo, ultrapassando cerca de 38% do PIB per capita.

Objective: Evaluate the cost-effectiveness of immunosuppressive regimens used in kidney transplant recipients at the Santa Casa de Misericórdia, Hospital in Juiz de Fora, MG, compared with basiliximab, mycophenolate sodium, tacrolimus and prednisone (Group 1 = 93 patients) with the association of thymoglobulin, everolimus, tacrolimus and prednisone (Group 2 = 91 patients). Methods: For the pharmacoeconomic analysis, the Decision Tree model was used, developed in the TreeAge Suite 2011 software. A real cohort of patients undergoing kidney transplantation between January 2013 and March 2017 was considered, they were followed up for a period of 1 year, where the clinical benefits were measured, as well as the associated costs, from the perspective

Análise do impacto das ações judiciais em um setor de referência de um hospital de grande porte de Juiz de Fora / Analysis of the impact of legal actions on a reference sector of a large hospital in Juiz de Fora

Objetivo: Avaliar o impacto das ações judiciais no setor de ortopedia da Santa Casa de Juiz de Fora/MG. Métodos: Foi realizada análise dos prontuários dos pacientes que passaram por cirurgia no setor de ortopedia da Santa Casa de Juiz de Fora no ano de 2016. E, logo após, os pacientes advindos de ação judicial foram identificados, dividindo-se, assim, a amostra em dois grupos. As variáveis analisadas foram: sexo e idade do paciente; tempo de internação, desfecho e custos, os quais foram desmembrados em diárias, honorários, procedimentos e materiais e medicamentos. Resultados: Os resultados demonstraram que os pacientes que realizaram cirurgias por via judicial são, em sua maioria, idosos, com leve predominância do sexo masculino. A maior das demandas é para a garantia de cirurgias do sistema osteomuscular de membros inferiores, representando 65,9% das cirurgias realizadas por ação judicial em 2016, que também são as cirurgias mais demandadas por via convencional. O custo direto das cirurgias por processos judiciais foi estimado em R$ 2.340.301,68. As diárias apresentaram o maior custo, sendo responsáveis por 90,7% de todo o custo estimado. Conclusão: A judicialização neste estudo expõe deficiências do Sistema Único de Saúde quanto à oferta de serviços, uma vez que todas as cirurgias demandadas por meio de ação judicial já são contempladas pelo sistema público de saúde. Assim, os aspectos judiciais da saúde, tais como a individualidade e os prazos para cumprimento, prevalecem sobre o coletivo e os que esperam nas filas.

Objective: Evaluate the impact of legal actions in the orthopedic sector of Santa Casa de Juiz de Fora/MG. Methods: An analysis was carried out of the medical records of patients who underwent surgery in the orthopedic sector of Santa Casa de Juiz de Fora in the year 2016. Soon afterwards, patients from a judicial action were identified, thus dividing the sample into two groups. The analyzed variables were: sex and age of the patient; time of hospitalization, outcome and costs, which were broken down into: daily, fees, procedures and materials and medicines. Results: The results showed that patients who underwent surgeries by judicial means are mostly elderly, with a slight predominance of males. The largest of the demands is to guarantee osteomuscular lower limb surgeries, accounting for 65.9% of surgeries performed by lawsuit in 2016, which are also the most commonly performed surgeries. The direct cost of surgeries for legal proceedings was estimated at R$ 2,340,301.68. The daily costs were those that presented the highest cost, accounting for 90.7% of the estimated cost. Conclusion: The judicialization in this study exposes deficiencies of the Unified Health System regarding the offer of services, once all the surgeries demanded by lawsuit are already contemplated by the public health system. Thus, the judicial aspects of health, such as: individuality and deadlines for compliance prevail over the collective and those waiting in the queues.

Pioneering evaluation of GaN transistors in geostationary satellites.

In this paper, we present the results of a 6-year experiment in space that studied the effects of radiation in Gallium Nitride (GaN) electronics in geostationary orbit. Four GaN transistors in a Colpitts oscillator configuration were flown in the Component Technology Test-Bed aboard the Alphasat telecommunication satellite. A heuristic analysis was performed by observing the variation in the power output of the oscillators with the total ionizing dose gathered during the mission. The total ionizing dose was measured with a Radiation Sensing Field Effect Transistors (RadFET) placed close to the GaN devices. The experiment showed that GaN is a robust technology that can be used in the space radiation environment of a geostationary orbit. The work presented here starts with a brief introduction of the subject, the motivation, and the main goal. This is followed by the description of the experimental setup, including the details of the oscillator design and simulations, as well as the implementation of the test-bed and the Components Technology Test-Bed. Finally, the results obtained during the 6 years of experience in space are discussed.

Mental Health Literacy: It Is Now Time to Put Knowledge into Practice.

The term 'mental health literacy' was first introduced in 1997, and it was defined as 'knowledge and beliefs about mental disorders which aid their recognition, management or prevention' [...].

Impact of the presence of partially erupted third molars on the local radiographic bone condition.

The decision on retaining or prophylactically removing asymptomatic lower third molars is still discussed in the literature. This study aimed to verify the association between asymptomatic lower third molars and local bone conditions through periapical radiographs. Based on sample size calculations, 288 radiographs were required. Dependent variables were alveolar bone crest status and radiolucency between the distal aspect of the third molar crown and the ascending mandibular ramus. Independent variables were sex, age, Pell and Gregory and Winter's classification, angulation and distance between second and third molars, third molar side. Advanced ages (OR 1.15; CI 1.08-1.24; p < 0.001) and greater third molar angulations (OR 1.03; CI 1.01-1.04; p < 0.001) significantly increased the chance of radiographic alterations in the bone crest between second and third molars. Radiolucency distal to third molars was solely impacted by patient's age (OR 1.05; CI 1.01-1.11; p = 0.036). Older patients and lower third molars with greater angulations about adjacent second molar should be evaluated for third molar removal because of the increased chance of alveolar bone crest alterations. Older patients should also be monitored for wider radiolucent pericoronal spaces distal to lower third molars and its consequences.

Prevalência de infecções hospitalares e assistência odontológica: um estudo transversal / Prevalence of hospital infections and dental care: a cross-sectional study

Objetivo:Realizar uma comparação entre a prevalência de infecções hospitalares pelo período de 13 meses entre dois grupos: pacientes internados sem assistência odontológica e com assistência odontológica. Métodos:O estudo é considerado do tipo transversal descritivo, através de dados referentes às taxas de infecções hospitalares obtidas em dois grupos, sem e com acompanhamento odontológico, considerando mais especificamente os setores: Centro de Terapia Intensiva (CTI) e Clínica Neurológica. Foram incluídos na amostra pacientes com idade superior a 16 anos, de ambos os gêneros e que apresentaram diagnóstico de infecção hospitalar após o período de 48 horas de internação ou 48 horas após a alta. Resultados:Entre março de 2016 à março de 2017, observou-se uma prevalência de infecção hospitalarde 3.14% em pacientes sem assistência odontológica e no período de março de 2017 à março de 2018, a prevalência foi de 2.85% nos pacientes que tiveram assistência odontológica. Conclusão: O CTI foi o setor de maior ocorrência das infecções. A assistência odontológica não se mostrou associada com as ocorrências de infecções.

Aim: To make a comparison between the prevalence of hospital infections over a period of 13 months between two groups: patients hospitalized without dental care and with dental care. Methods:This was a descriptive cross-sectional study, through data regarding the rates of hospital infections obtained in two groups: with and without dental care, considering more specifically the sectors: Intensive care unit (ICU) and neruological clinic. Patients over 16 years-old, of both genders and who were diagnosed withhospital infection after 48 hours of hospitalization or 48 hours after discharge, were included in the sample. Results: Between March 2016 and March 2017, a prevalence of hospital infection was observed of 3. 14% in patients without dental care and from March 2017 to March 2018, the prevalence was 2. 85% in patients who had dental care. Conclusion: The ICU was the sector with the highest occurrence of infections. Dental care was not associated with the occurrence of infections.

A source of very energetic oxygen located in Jupiter's inner radiation belts.

Jupiter hosts the most hazardous radiation belts of our solar system that, besides electrons and protons, trap an undetermined mix of heavy ions. The details of this mix are critical to resolve because they can reveal the role of Jupiter's moons relative to other less explored energetic ion sources. Here, we show that with increasing energy and in the vicinity of Jupiter's moon Amalthea, the belts' ion composition transitions from sulfur- to oxygen-dominated due to a local source of ≳50 MeV/nucleon oxygen. Contrary to Earth's and Saturn's radiation belts, where their most energetic ions are supplied through atmospheric and ring interactions with externally accelerated cosmic rays, Jupiter's magnetosphere powers this oxygen source internally. The underlying source mechanism, involving either Jovian ring spallation by magnetospheric sulfur or stochastic oxygen heating by low-frequency plasma waves, puts Jupiter's ion radiation belt in the same league with that of astrophysical particle accelerators.

Análise retrospectiva das atividades desenvolvidas pelo grupo PET Odontologia no Vale / Retrospective analysis of activities developed by the PET Dentistrygroup in the Valley

O Programa de Educação Tutorial(PET) visa fortalecer o modelo de indissociabilidade de ensino, pesquisa e extensão,contribuindo para processo de ensino e aprendizagem nas instituições de ensino superior brasileiras. O grupo PET Odontologia no Vale foi fundado em 2009 na Universidade Federal dos Vales do Jequitinhonha e Mucuri(UFVJM). Desde então, o grupo atua no desenvolvimento de atividades que abrangem a integração dialógica, com ações voltadas à formação acadêmica de excelência e às necessidades de saúde da comunidade, considerando a realidade social, cultural e econômica do Vale do Jequitinhonha. O presente artigo teve por objetivo reportar as atividades desenvolvidas pelo grupo PET Odontologia no Vale no período de 2013 a 2020. Foram documentadas 93 atividades, que compreenderam 49 ações de ensino, 35 de extensão e 9 de pesquisa. Destas, 79 foram plenamente desenvolvidas e 14 foram parcialmente desenvolvidas. Referente ao público-alvo, 71 (76,34%) foram destinadas à comunidade acadêmica da UFVJM e 15 ações (16,13%) à comunidade externa. Esses resultados apontam a importância do PET Odontologia no Vale e seus valores no contexto em que o grupo se insere (AU).

The Tutorial Education Program (PET) aims to strengthen the model of inseparable teaching, research, and extension, contributing to the teaching and learning process in the Brazilian higher education institutions. The PET Dentistry in the Valley group was founded in 2009 at the Federal University of the Vales do Jequitinhonha e Mucuri (UFVJM). Since then, the group has been active in the development of activities that cover dialogic integration, with actions aimed at excellent academic training and community health needs, considering the social, cultural, and economic realities of the Jequitinhonha Valley. This article aimed to report the activities developed by the PET Dentistry in the Valley group from 2013 to 2020. Ninety-three activities were documented,comprising 49 teaching actions, 35 extensions, and 9 research. Of these, 79 have been fully developed and 14 have been partially developed. Regarding the target audience, 71 (76.34%) were aimed at the academic community at UFVJM and 15 actions (16.13%) atthe external community. These results show the importance of PET Dentistry in the Valley and its values in the context in which the group is inserted (AU).

Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis.

BACKGROUND: Prevalence of Grade C molar incisor periodontitis (C/MIP) in females (F) and males (M) is controversial, although some studies suggest higher prevalence in females. The objective of this study was to evaluate differences in clinical parameters, and levels of cyto/chemokines in gingival crevicular fluid (GCF) and peripheral blood response. METHODS: GCF and blood were collected from 79 C/MIP African-American participants (53F and 26 M) and healthy controls (58F and 38 M), aged 5 to 23. Blood was stimulated with ultrapure LPS from Escherichia coli (Ec) and Porphyromonas gingivalis (Pg) and we quantified levels of 14 cyto/chemokines. Clinical parameters were collected before and 12 months following treatment RESULTS: No clinical parameters or age differences were found between males and females, although age was negatively correlated with response to treatment. GCF levels of TNFα, IFNγ, MIP1α, and MCP1 from diseased and sites and healthy sites IFNγ levels were higher in M (P < 0.05). C/MIP females presented higher Pg and Ec LPS induced levels of Eotaxin, IFNγ, and GMCSF (P < 0.05), whereas healthy males presented higher Ec LPS induced levels of Eotaxin and IFNγ (P < 0.05). Inflammatory profiles were also different among genders in disease (P = 0.004). CONCLUSIONS: Although males seemed to present few elevated inflammatory markers in the GCF in disease and in health, females presented an elevated systemic inflammatory response to LPS in disease, which indicates a possible differential susceptibility to inflammation. Future studies need to determine if sex hormones have a role in the peripheral host response and in the pathogenesis of C/MIP.

Developing nursing clinical data models addressing delusion and hallucination with Meleis transitions theory as the theoretical reference model: A focus group study.

PURPOSE: To build the final clinical data models regarding the nursing focuses "Delusion" and "Hallucination" with Meleis transitions theory as the theoretical reference model. DESIGN AND METHODS: A qualitative descriptive design was adopted, using two focus groups. FINDINGS: The clinical data models obtained by this study recognize a perspective centered on the client's transition, which emphasizes the role of nursing in relation to a client suffering from delusion and hallucination. IMPLICATIONS FOR NURSING PRACTICE: These clinical data models may contribute towards improving nursing clinical decision-making and nursing care quality regarding these areas.

Relação entre tratamento protético, autoestima e qualidade de vida em pacientes idosos em tratamento hemodialítico / Relationship between prosthetic treatment, self-esteem and quality of life in elderly patients undergoing hemodialysis

Fundamento: O estado de saúde bucal pode ter influência física e psicológica sobre a vida dos indivíduos. Pode afetar simultaneamente o prazer na vida devido a interferência nas condições bucais, na fala, mastigação, sabor e deglutição, nos domínios sociais, sobre a aparência e autoconfiança dos indivíduos. Objetivo:Verificar se o tratamento protético odontológico é capaz de gerar melhoria na qualidade de vida e na autoestima de pacientes idosos submetidos a hemodiálise. Materiais e Métodos: Realizou-se um estudo intervencional com 26 pacientes submetidos à hemodiálise na cidade de Diamantina, Brasil. Os pacientes foram divididos em dois grupos de acordo com a realização do tratamento; com e sem tratamento. O grupo tratamento recebeu ajustes ou confecção de uma nova prótese odontológica, já o grupo sem tratamento recebeu apenas avaliação clínica e orientações sobre higiene bucal. A qualidade de vida foi avaliada através do instrumento Medical Outcomes Study 36-Item Short Form Health Questionnaire (SF-36) e Oral Health Impact Profile (OHIP) na sua versão 14. Já para a autoestima utilizou-se a Escala de Autoestima de Rosenberg. Resultados: A média de idade foi 69,08 anos (±05,90) e o índice CPO-D médio foi de 29,65 (±01,35). Houve significância estatística na dimensão aspecto emocional do SF-36 nos dois grupos. O grupo que recebeu tratamento apresentou significância na incapacidade física do OHIP-14 e melhora da autoestima. Conclusão: O tratamento protético odontológico gerou melhoria na qualidadede vida e impactou na autoestima de pacientes idosos submetidos à hemodiálise, sendo o impacto maior nos pacientes que realizaram tratamento protético

Background: Oral health status can have a physical and psychological influence on individuals' lives. It can simultaneously affect the pleasure in life due to interference in oral conditions, speech, chewing, taste and swallowing, in social domains, on the appearance and self-confidence of individuals. Objective:To verify whether dental prosthetic treatment is able to improve the quality of life and self-esteem of elderly patients undergoing hemodialysis. Materials and Methods: An interventional study was carried out with 26 patients undergoing hemodialysis in the city of Diamantina, Brazil. Patients were divided into two groups according to treatment completion; with and without treatment. The treatment group received adjustments or made a new dental prosthesis, while the group without treatment received only clinical evaluation and guidance on oral hygiene. Quality of life was assessed using the instrument Medical Outcomes Study 36-Item Short Form Health Questionnaire (SF-36) and Oral Health Impact Profile (OHIP) in its version 14. For self-esteem, the Rosenberg Self-Esteem Scale was used. Results:The mean age was 69.08 years (±05.90) and the mean DMFT index was 29.65 (±01.35). There was statistical significance in the emotional aspect dimension of the SF-36 in both groups. The group that received treatment showed significance in the physical disability of the OHIP-14 and improvement in self-esteem. Conclusion:Dental prosthetic treatment improved the quality of life and impacted the self-esteem of elderly patients undergoing hemodialysis, with the greatest impact on patients who underwent prosthetic treatment.

Relationship between stress and bruxism in university students: a cross-sectional study

Background: Bruxism is defined as repetitive masticatory muscle activity characterized by clenching or grinding of the teeth and it has been related to psychological factors, such as personality traits, anxiety and stress. Objective: To investigate association between stress and bruxism among university students. Materials and methods:Lipp's Stress Symptoms Inventory for Adults (LSSI) was applied to 253 university students in Diamantina, Brazil. The y were clinically evaluated to verify dental wear. The non-instrumental evaluation of probable bruxism was determined by the patients' reports. Sociodemographic variables and self-reported stress data were collected by usi ng the questionnaire. The chi-square test was used, and significance level of 5% ( p<0.05) was adopted. Results: The prevalence of bruxism was 45.8% and stress, 37.9%. There was no significant association between the presence of stress diagnosed by ISSL and bruxism (p = 0.815). Among the students diagnosed as stressed, 31.6% were in the resistance phase. Self-reported stress was associated with the habit of tooth grinding (p < 0.001). Conclusions: No association was found between stress and bruxism. Nevertheless, the prevalence of bruxism among these students was considered high.

Fundamento: O bruxismo é definido como atividade muscular repetitiva da mastigação caracterizada pelo ranger dos dentes e tem sido relacionado a fatores psicológicos, como traços de personalidade, ansiedade e estresse. Objetivo: Verificar a associação entre estresse e bruxismo em universitários. Materiais e métodos:O Inventário de Sintomas de Stress para Adultos de Lipp (ISSL) foi aplicado a 253 estudantes universitários em Diamantina, Brasil. Eles foram avaliados clinicamente para verificar o desgaste dentário. A avaliação não instrumental de provável bruxismo foi determinada pelos relatos dos pacientes. Variáveis sociodemográficas e dados de estresse autorreferido foram coletados por meio do questionário. Foi utilizado o teste do qui-quadrado e adotado nível de significância de 5% (p <0,05). Resultados: A prevalência de bruxismo foi 45,8% e estresse, 37,9%. Não houve associação significativa entre a presença de estresse diagnosticado pelo ISSL e bruxismo (p = 0,815). Entre os alunos com diagnóstico de estresse, 31,6% encontravam-se na fase de resistência. O estresse autorreferido foi associado ao hábito de ranger os dentes (p <0,001). Conclusões: Não foi encontrada associação entre estresse e bruxismo. Apesar disso, a prevalência de bruxismo entre esses estudantes foi considerada alta.

Percepção da qualidade de vida e autoestima após intervenção odontológica e transplante renal: uma série de casos / Quality of life perception and self-esteem after dental intervention and kidney transplantation: a case series

Contexto: a insuficiência renal crônica dá-se quando os rins deixam de desenvolver suas multitarefas com eficácia, levando o paciente à hemodiálise ou transplante renal e a um progressivo desgaste emocionalObjetivo:avaliar percepção da qualidade de vida relacionada à saúde bucal e autoestima de pacientes submetidos à hemodiálise, após intervenções odontológicas e transplantes renais. Materiais e Métodos: Oitenta e dois pacientes responderam aos questionários SF-36, OHIP-14 e Escala de Autoestima de Rosenberg. Destes, 76 passaram por intervenções odontológicas e responderam aos questionários novamente. Após 3 anos, apenas 33 deram continuidade ao estudo. Doze foram transplantados e 10 responderam aos questionários ao final. Resultados:Apenas a autoestima mostrou melhora, com alterações estatisticamente significativas. Conclusão:Tratamento odontológico e transplante renal melhoraram a autoestima dos pacientes. Houve uma tendência de melhora no aspecto social.

Background: Chronic kidney failure occurs when the kidneys fail to perform their multitasking effectively, leading the patient to hemodialysis or kidney transplantation and progressive emotional exhaustionObjective:to evaluate the perception of quality of life related to oral health and self-esteem of patients undergoing hemodialysis, after dental interventions and kidney transplants. Materials and Methods:Eighty-two patients answered the SF-36, OHIP-14 and Rosenberg Self-Esteem Scale questionnaires. Of these, 76 underwent dental interventions and answered the questionnaires again. After 3 years, only 33 continued the study. Twelve were transplanted and 10 completed the questionnaires. Results:Only self-esteem showed improvement, with statistically significant changes. Conclusion:Dental treatment and kidney transplantation improved patients' self-esteem. There was a trend towards improvement in the social aspect.