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1.
JACC Case Rep ; 29(5): 102232, 2024 Mar 06.
Article in English | MEDLINE | ID: mdl-38464804

ABSTRACT

Paragangliomas are rare extra-adrenal tumors originating from chromaffin cells. We discovered a large intrapericardial mass confirmed to be a primary cardiac paraganglioma encasing the left main stem coronary artery in a 38-year-old woman who presented with dyspnea and subscapular pain. Genetic predisposition related to succinate dehydrogenase A mutation was identified.

2.
BMJ Case Rep ; 14(1)2021 Jan 28.
Article in English | MEDLINE | ID: mdl-33509881

ABSTRACT

Kikuchi disease is a rare, benign condition of unknown aetiology, which usually involves young women and is characterised by cervical lymphadenopathy and fever. Herein, we are reporting a case of a young Asian woman, who presented with fever and lymphadenopathy raising possibility of either infection or malignancy but after appropriate clinical investigations including lymph node biopsy, it turned out to be Kikuchi disease. She made an uneventful complete recovery with only symptomatic treatment.


Subject(s)
Fever/physiopathology , Histiocytic Necrotizing Lymphadenitis/diagnosis , Lymphadenopathy/pathology , Adult , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antipyretics/therapeutic use , Biopsy , Diagnosis, Differential , Female , Fever/drug therapy , Histiocytic Necrotizing Lymphadenitis/pathology , Histiocytic Necrotizing Lymphadenitis/physiopathology , Histiocytic Necrotizing Lymphadenitis/therapy , Humans , Lupus Erythematosus, Systemic/diagnosis , Lymph Nodes/pathology , Lymphadenopathy/physiopathology , Lymphoma/diagnosis , Neck
3.
Cureus ; 12(9): e10184, 2020 Sep 01.
Article in English | MEDLINE | ID: mdl-32905195

ABSTRACT

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare disorder that classically involves the musculoskeletal system, i.e. bone, joint and skin. The exact pathogenesis of this syndrome is unknown. However, autoimmunity, infections, immune malfunction and genetic factors are attributed to its pathophysiology. Bone and joint involvements are the hallmark of SAPHO syndrome and not necessarily require cutaneous involvement at the time of diagnosis. X-ray of the affected joints could show osteitis with sclerosis. Anterior chest wall involvement particularly ''bullhead appearance'' seen on bone scan is a striking feature of the syndrome. Erythrocyte sedimentation rate (ESR) is usually elevated amongst the majority of patients. Diagnosis of SAPHO is always challenging and often delayed because of a multitude of symptoms. The mainstay of treatment is control of pain and inflammation with both non-steroidal anti-inflammatory drugs (NSAIDs) and rescue courses of systemic steroids. If failed to control symptoms with first-line agents and in those with severe disease, disease-modifying anti-inflammatory drugs (DMARDs) may be needed eventually. Despite a chronic inflammatory condition, it remains stable in the majority of cases. Here in this case report, we reiterate the importance of early recognition, timely diagnosis and prompt treatment initiation.

4.
Cureus ; 12(8): e9719, 2020 Aug 13.
Article in English | MEDLINE | ID: mdl-32821628

ABSTRACT

Shewanella species are opportunistically pathogenic, gram-negative bacilli that are part of marine microflora. Infection caused by Shewanella species in humans is rare and mostly acquired after direct contact with seawater or ingestion of raw seafood. The exact pathogenesis remains unclear. Cutaneous infections are among the most common manifestation with underlying skin diseases and immune-compromised states; however, bacteremia from lungs, abdominal, and biliary sepsis has also been reported. These infections are difficult to diagnose due to limited physicians' experience and scarce microbiological data available. Hence, delayed diagnosis and treatment could be fatal and may result in sepsis with multi-organ failure. Our case report reiterates the fact that careful attention should be devoted to unusual circumstances in history and atypical pathogens on cultures if there is no or minimal clinical improvement after antibiotics.

5.
Eur Heart J Case Rep ; 4(6): 1-5, 2020 Dec.
Article in English | MEDLINE | ID: mdl-33447707

ABSTRACT

BACKGROUND: Acute pericarditis is frequently encountered in clinical practice; however, pericarditis as the first presentation of Graves' disease is rare and mainly limited to case reports in the literature. We hereby report a case in which a young patient presented with pericarditis as the first manifestation of Graves' disease. CASE SUMMARY: A 24-year-old male was admitted to hospital with presenting complaint of left-sided chest pain, gradual in onset, 6/10 in intensity, sharp in character, increased by deep breathing and improved by leaning forward. Patient also gave a history of insomnia, unintentional weight loss despite a good appetite, heat intolerance, and anxiety. On clinical examination, the patient had features of thyrotoxicosis, i.e., tachycardia, high volume pulse, and sweaty palms with fine tremors. There was no associated pericardial rub. Neck examination shows diffuse, non-tender goitre. Electrocardiogram findings were consistent with acute pericarditis. His thyroid function tests demonstrated hyperthyroidism and anti-thyroglobulin antibodies were also significantly elevated. Echocardiogram showed preserved left ventricular systolic function and a small global pericardial effusion without any signs of tamponade. He was diagnosed with Graves' disease revealing itself as pericarditis and was started on ibuprofen, beta-blockers, and carbimazole. Patient had marked clinical and biochemical improvement on 3 monthly follow-ups. DISCUSSION: Thyro-pericarditis is a rare entity, and limited literature is available regarding this combination. The exact aetiology of Graves associated pericarditis is unknown. There is a possibility of interaction of autoantibodies with receptors on pericardium. Diagnosis is based on a detailed history, clinical examination, supplemented by relevant investigations (elevated free T4 and thyroid receptor antibodies, suppressed thyroid stimulating hormone (TSH) and Imaging via ultrasound). Mainstay of treatment includes non-steroidal anti-inflammatory drugs, beta-blockers, and anti-thyroidal medications.

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