Immediate effect of hallux valgus surgery on the biomechanical behavior of the first ray.

BACKGROUND: The surgical treatment of hallux valgus (HV) deformity has been the subject of countless publications but few focus on the altered windlass mechanism or analyze the biomechanical behavior immediately after surgery. METHODS: Patients treated for HV between January and March 2023 were included. The surgery consisted of a L-reverse first metatarsal osteotomy. To analyze the windlass mechanism we record two different measurements; the isolated first metatarsophalangeal joint (MTPJ) dorsiflexion angle (IDA) and dynamic plantarization of the first metatarsal head when performing first MTPJ dorsiflexion imprinting a mark on a modeling foam. RESULTS: A total of 30 patients diagnosed with symptomatic HV were included. In all patients, a change in the IDA angle was evident, being overall statistically significant. About modeling foam imprinted mark, all measurements, in all planes of space, had a clear tendency to increase, which turned out to be statistically significant (p < 0.001). CONCLUSIONS: An altered windlass mechanism may be successfully recovered immediately after hallux valgus deformity surgery. This could be evinced by an indirect measurement analyzing the imprint of the head of the first metatarsal in a modeling foam and the IDA. LEVELS OF EVIDENCE II: None.

Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance-related lesions in Latin America.

BACKGROUND: Monoclonal gammopathy of renal significance (MGRS)-related lesions are infrequent entities. There are no publications on these disorders in Latin America (LA). The aim of this study was to describe epidemiological and clinical characteristics of these patients in LA. METHODS: We performed a multicentre retrospective study. Patients with diagnosis of MGRS between 2012 and 2018 were included. Epidemiological and clinical data were collected from clinical records. RESULTS: Twenty-seven patients from Chile, Argentina, Ecuador and Uruguay were included. Half debuted with a nephrotic syndrome, and 32% required dialysis. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits was found in 33%, amyloidosis in 26% and monoclonal immunoglobulin deposition disease also in 26%. The immunoglobulin most frequently found in renal biopsies was IgG kappa. In 67% a paraprotein was found. Twenty patients received an anti-plasma cell regimen, and 3 a rituximab-based regimen (IgM-MGRS). Renal response (RR) was achieved in 56%. Early treatment (≤3 months) was associated with higher RR (75% vs 43%). Three patients relapsed within 21.5 months, and 3 progressed: 1 to multiple myeloma, 1 to systemic amyloidosis and another to systemic light-chain deposition disease. Two patients died, both due to infection during induction treatment. CONCLUSION: There was a higher than expected frequency of patients requiring dialysis. The most common MGRS-related lesion was PGNMD. Early treatment was associated with better response. As a rare disease, increasing awareness and promoting early diagnosis are necessary in LA to improve outcomes. SUMMARY AT A GLANCE A collection of 27 cases of MGRS from Latin America with information on epidemiology, clinical characteristics, treatment and outcome of patients diagnosed of MGRS-related renal lesions.

AL amyloidosis in the Chilean public health system: a pending debt: multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group / Amiloidosis AL en el sistema público de Chile: una deuda pendiente: estudio multicéntrico

ABSTRACT Background: Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity. Aim: To characterize patients with AL amyloidosis in Chilean public health centers. Material and Methods: We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal Gammopathies Cooperative Group were asked to search for patients with AL amyloidosis in their databases. Epidemiological, clinical and laboratory characteristics were evaluated. Results: Forty-two patients aged 22 to 84 years were found. Twenty four percent had localized AL amyloidosis; 64% had a lambda light chain clone; 47% were associated with multiple myeloma and 9% with non-Hodgkin lymphoma. The most commonly involved organ was the kidney (76%). Serum free light chains were measured in 31% and an echocardiogram was performed in 74% of patients. Seventeen percent of patients received only palliative care, 17% were treated with bortezomib, 21% with thalidomide, and 40% with melphalan. No patient was transplanted. The mean overall survival (OS) of the group was 19 months. The 5-year OS was 28%. Conclusions: It is important to obtain these realistic, national data to initiate strategies to improve early diagnosis and proper management of this disease.

La amiloidosis AL es una entidad poco frecuente y subdiagnosticada. Mientras todo el mundo discute sobre las nuevas herramientas diagnósticas y terapéuticas, en Chile y en América Latina en general, estamos lejos de esa realidad. El objetivo del presente estudio fue caracterizar a los pacientes con amiloidosis AL en centros del sistema público de nuestro país. Se realizó un estudio retrospectivo, multicéntrico, descriptivo. Los centros públicos del grupo cooperativo hematológico chileno buscaron en sus bases de datos pacientes diagnosticados con amiloidosis AL. Se evaluaron las características epidemiológicas, clínicas y de laboratorio. La edad media fue de 65 años. A 24% de los pacientes se les diagnosticó amiloidosis AL localizada; 64% tuvo paraproteína con cadena ligera lambda; 47% se asoció con mieloma múltiple y 9% con linfoma no Hodgkin. El órgano afectado con mayor frecuencia fue el riñón (76%). Las cadenas ligeras libres de suero se realizaron en 31% y ecocardiograma en 74%. El 17% recibió solo cuidados paliativos, 17% recibió tratamiento con bortezomib, 21% con talidomida y 40% con melfalán. Ningún paciente fue trasplantado. La media de sobrevida global (SG) del grupo fue de 19 meses. La SG a 5 años fue de 28%. Es importante reportar estos resultados nacionales para iniciar estrategias que mejoren tanto el diagnóstico temprano como el tratamiento de esta patología. Por lo tanto, mejorar la sospecha diagnóstica es crucial.

Tendencias y perfil de publicación de los cirujanos plásticos de los 22 países miembros de la FILACP, revisión de los últimos 20 años / Publishing trends and profile of plastic surgeons from the 22 countries members of the FILACP, revision of the last 20 years

Introducción y Objetivo: La publicación científica es una actividad académica fundamental, constituyendo una fuente de conocimiento y actualización. El objetivo de este trabajo es conocer el perfil y la tendencia de publicación de los cirujanos plásticos de las 22 naciones que componen la Federación Ibero Latinoamericana de Cirugía Plástica (FILACP) durante los últimos 20 años. Material y Método: Revisión en Pubmed, Lilacs, Scielo, Central (Cochrane) y Tripdatabase, desde el 1 de enero de 1998 al 1 de enero del 2018 bajo los términos: (Cirugía Plástica OR Plastic Surgery) AND: Chile, Argentina, Bolivia, Perú, Colombia, Brasil, Venezuela, Ecuador, Uruguay, Paraguay, Panamá, Costa Rica, Nicaragua, Guatemala, Honduras, El Salvador, México, República Dominicana, Cuba, Puerto Rico, España y Portugal, cada país por separado. Consideramos todos los trabajos que incluyeran entre sus autores al menos un cirujano plástico de su respectivo país y analizamos: pertenencia a su Sociedad Nacional de Cirugía Plástica (SNCP), participación de residentes, centro o campo clínico, tema, grupo etario objetivo, año de publicación y revista. Resultados: Revisamos 6387 publicaciones; 3000 artículos cumplieron criterios de inclusión. Los países con mayor número de publicaciones fueron Brasil (998), España (989) y México (310), seguidos de Portugal (167), Argentina (162), Chile (125) y Colombia (95). En global, el 89.3% de los autores eran miembros de su respectiva SNCP. Predominó como temática lo reconstructivo (47.6%), los estudios en adultos (73.2%) y los centros universitarios (58.2%). Las principales revistas de publicación corresponden a Cirugía Plástica Ibero-Latinoamericana y Plastic and Reconstructive Surgery. Conclusiones: Existe un aumento sostenido en la publicación científica por parte de los cirujanos plásticos de los países de la FILACP, en especial en la última década. Llama la atención la poca participación de residentes (8.4%), lo cual creemos corresponde a un reporte insuficiente de su calidad de residentes entre los autores

Background and Objective: Scientific publication is a fundamental academic activity, constituting a source of update and knowledge. The objective of this article was to find out about the publishing profile and trend of plastic surgeons from the 22 countries that conform the Ibero Latin American Federation of Plastic Surgery (FILACP) during the last 20 years. Methods: Literature Review in Pubmed, Lilacs, Scielo, Central (Cochrane) and Tripdatabase, from January 1, 1998 to January 1, 2018 under the terms: (Plastic Surgery OR Cirugía Plástica) AND: Chile, Argentina, Bolivia, Peru, Colombia, Brazil, Venezuela, Ecuador, Uruguay, Paraguay, Panama, Costa Rica, Nicaragua, Guatemala, Honduras, El Salvador, Mexico, Dominican Republic, Cuba, Puerto Rico, Spain and Portugal, each country separately. Articles with at least one plastic surgeon from the respective country between the authors were included and analyzed by: membership of their National Plastic Surgery Society, resident participation, center, subject, objective age group, year of publication and journal. Results: 6387 publications were reviewed; 3000 articles met inclusion criteria. The countries with the highest number of publications were Brazil (998), Spain (989) and Mexico (310), followed by Portugal (167), Argentina (162), Chile (125) and Colombia (95). Overall, 89.3% of the authors were members of their corresponding National Plastic Surgery Societies. Reconstructive themed papers predominated (47.6%), as well as studies in Adults (73.2%) and Academic centers (58.2%). The main publication journals were Cirugía Plástica Ibero-Latinoamericana and Plastic and Reconstructive Surgery. Conclusions: There is a sustained increase in scientific publication by plastic surgeons from the countries of the FILACP, especially in the last deca- de. The low participation of residents draws attention (8.4%), however we believe it corresponds to an insufficient report about their role as residents among the authors

AL amyloidosis in the Chilean public health system: a pending debt. Multicenter study of the Chilean Monoclonal Gammopathies Cooperative Group.

BACKGROUND: Immunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed entity. AIM: To characterize patients with AL amyloidosis in Chilean public health centers. MATERIAL AND METHODS: We conducted a retrospective, multicenter study. Public centers of the Chilean Monoclonal Gammopathies Cooperative Group were asked to search for patients with AL amyloidosis in their databases. Epidemiological, clinical and laboratory characteristics were evaluated. RESULTS: Forty-two patients aged 22 to 84 years were found. Twenty four percent had localized AL amyloidosis; 64% had a lambda light chain clone; 47% were associated with multiple myeloma and 9% with non-Hodgkin lymphoma. The most commonly involved organ was the kidney (76%). Serum free light chains were measured in 31% and an echocardiogram was performed in 74% of patients. Seventeen percent of patients received only palliative care, 17% were treated with bortezomib, 21% with thalidomide, and 40% with melphalan. No patient was transplanted. The mean overall survival (OS) of the group was 19 months. The 5-year OS was 28%. CONCLUSIONS: It is important to obtain these realistic, national data to initiate strategies to improve early diagnosis and proper management of this disease.

[Toxic epidermal necrolysis during a hemophagocytic syndrome secondary to Hodgkin lymphoma. Report of one case]. / Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin. Caso clínico.

Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemophagocytosis. The concomitance of these diseases is extremely uncommon. We report a 38 years old female, who during the course of a HFS secondary to Hodgkin Lymphoma (HL), presented a TEN secondary to antibiotics. She was admitted due to a consumptive syndrome, lymphadenopathy, visceromegaly and severe pancytopenia. Laboratory and bone marrow tests confirmed HFS. Due to constant fever, imipenem was indicated. On the third day she started with pain and skin rash. She evolved with positive Nikolsky sign. Cutaneous biopsy was concordant with extensive TEN, which was managed with intravenous immunoglobulin and dexamethasone. A complete response and normalization of the blood count were achieved. Finally, the lymph node biopsy showed HL of mixed cellularity type, which was managed with 8 cycles of ABVD chemotherapy, achieving complete remission.

Necrolisis epidérmica tóxica en el curso de un síndrome hemofagocítico secundario a linfoma de Hodgkin: caso clínico / Toxic epidermal necrolysis during a hemophagocytic syndrome secondary to Hodgkin lymphoma: report of one case

Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemophagocytosis. The concomitance of these diseases is extremely uncommon. We report a 38 years old female, who during the course of a HFS secondary to Hodgkin Lymphoma (HL), presented a TEN secondary to antibiotics. She was admitted due to a consumptive syndrome, lymphadenopathy, visceromegaly and severe pancytopenia. Laboratory and bone marrow tests confirmed HFS. Due to constant fever, imipenem was indicated. On the third day she started with pain and skin rash. She evolved with positive Nikolsky sign. Cutaneous biopsy was concordant with extensive TEN, which was managed with intravenous immunoglobulin and dexamethasone. A complete response and normalization of the blood count were achieved. Finally, the lymph node biopsy showed HL of mixed cellularity type, which was managed with 8 cycles of ABVD chemotherapy, achieving complete remission.