Clinical and Translational Science Personas: Expansion and use cases.

Twelve evidence-based profiles of roles across the Clinical and Translational Science (CTS) workforce and two patient profiles were developed by CTS Personas collaborators in 2019 as part of the CTSA Program National Center for Data to Health (CD2H). Based on feedback received from the community, CTS Personas team members collaborated to produce five additional Personas to broaden representation of the CTS workforce and enhance the existing portfolio. This paper presents the rationale and methodology used in the latest CTS Personas initiative. This work also includes an implementation scenario incorporating multiple Personas. Using the new National Institutes of Health's (NIH) Data Management and Sharing Policy as an example, we demonstrate how administrators, researchers, support staff, and all CTS collaborators can use the Personas to respond to this new policy while considering the needs of service providers and users, CTS employees with short- and long-term needs, and interdisciplinary perspectives.

Bridging the gap: A library-based collaboration to enhance data skills for clinical researchers.

Introduction: Enterprise data warehouses (EDWs) serve as foundational infrastructure in a modern learning health system, housing clinical and other system-wide data and making it available for research, strategic, and quality improvement purposes. Building on a longstanding partnership between Northwestern University's Galter Health Sciences Library and the Northwestern Medicine Enterprise Data Warehouse (NMEDW), an end-to-end clinical research data management (cRDM) program was created to enhance clinical data workforce capacity and further expand related library-based services for the campus. Methods: The training program covers topics such as clinical database architecture, clinical coding standards, and translation of research questions into queries for proper data extraction. Here we describe this program, including partners and motivations, technical and social components, integration of FAIR principles into clinical data research workflows, and the long-term implications for this work to serve as a blueprint of best practice workflows for clinical research to support library and EDW partnerships at other institutions. Results: This training program has enhanced the partnership between our institution's health sciences library and clinical data warehouse to provide support services for researchers, resulting in more efficient training workflows. Through instruction on best practices for preserving and sharing outputs, researchers are given the tools to improve the reproducibility and reusability of their work, which has positive effects for the researchers as well as for the university. All training resources have been made publicly available so that those who support this critical need at other institutions can build on our efforts. Conclusions: Library-based partnerships to support training and consultation offer an important vehicle for clinical data science capacity building in learning health systems. The cRDM program launched by Galter Library and the NMEDW is an example of this type of partnership and builds on a strong foundation of past collaboration, expanding the scope of clinical data support services and training on campus.

Ten simple rules for maximizing the recommendations of the NIH data management and sharing plan.

The National Institutes of Health (NIH) Policy for Data Management and Sharing (DMS Policy) recognizes the NIH's role as a key steward of United States biomedical research and information and seeks to enhance that stewardship through systematic recommendations for the preservation and sharing of research data generated by funded projects. The policy is effective as of January 2023. The recommendations include a requirement for the submission of a Data Management and Sharing Plan (DMSP) with funding applications, and while no strict template was provided, the NIH has released supplemental draft guidance on elements to consider when developing a plan. This article provides 10 key recommendations for creating a DMSP that is both maximally compliant and effective.

Intervención psicomotriz para el desarrollo de la identidad de madres adolescentes del proyecto "segunda oportunidad" del Gobierno Municipal de La Paz / Psychomotor intervention for the development of the identity of adolescent mothers of the "second chance" project of the Municipal Government of La Paz

El objetivo del presente trabajo es comprender forma de ser y estar de las madres adolescentes desde una mirada sicomotriz, para así entender el fenómeno de la maternidad en la adolescencia tomando en cuenta el punto de vista de cada una y a su vez desde una perspectiva colectiva, y de esta forma plantear una intervención desde la psicomotricidad.

Personas for the translational workforce.

Twelve evidence-based profiles of roles across the translational workforce and two patients were made available through clinical and translational science (CTS) Personas, a project of the Clinical and Translational Science Awards (CTSA) Program National Center for Data to Health (CD2H). The persona profiles were designed and researched to demonstrate the key responsibilities, motivators, goals, software use, pain points, and professional development needs of those working across the spectrum of translation, from basic science to clinical research to public health. The project's goal was to provide reliable documents that could be used to inform CTSA software development projects, educational resources, and communication initiatives. This paper presents the initiative to create personas for the translational workforce, including the methodology, engagement strategy, and lessons learned. Challenges faced and successes achieved by the project may serve as a roadmap for others searching for best practices in the creation of Persona profiles.

Translational Personas and Hospital Library Services.

Academic health centers, CTSA hubs, and hospital libraries experience similar funding challenges and charges to do more with less. In recent years academic health center and hospital librarians have risen to these challenges by examining their service models, and beyond that, examining their patron base and users' needs. To meet the needs of employees, patients, and those who assist patients, hospital librarians can employ the CTS Personas, a project of the Clinical and Translational Science Awards (CTSA) Program National Center for Data to Health. The Persona profiles, which outline the motivations, goals, pain points, wants, and needs of twelve employees and two patients in translational science, provide vital information and insights that can inform everything from designing software tools and educational services, to advertising these services, to designing impactful and collaborative library spaces.

Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.

Schizophrenia is a chronic, often progressive, disorder. Understanding the underlying neurobiology present in the early stages of the illness is as a pivotal step in designing targeted interventions aimed at arresting disease progression. The aim of our study was to examine neurometabolic changes in the dopamine rich associative striatum in medication-naïve first episode psychosis (FEP). We quantified neurometabolites in 14 FEP and 18 healthy controls (HC) matched on key demographic characteristics. Spectra from the voxel in the left associative striatum were acquired using a PRESS sequence (TR/TE = 2000/80 ms; 512 averages). MRS data were quantified in the time domain with AMARES in jMRUI. Choline was significantly elevated in FEP compared to HC. No significant alterations in other metabolites were observed. We did not observe correlations between metabolite levels and clinical characteristics in FEP. Here, we demonstrated elevated choline and a disruption of the relationship between N-acetyl-aspartate and Glx (glutamate + glutamine) in medication-naïve FEP patients in the left striatum indicating possible mitochondrial, membrane and glial dysfunction as an underlying pathological phenomenon. In addition, striatal choline shows promise as a biomarker for FEP that may have utility in clinical trials investigating target engagement in experimental regimens.

Transcolonic Migration of Retained Epicardial Pacing Wires.

Temporary epicardial pacing wires are associated with rare complications. Most of these occur in the chest. Even rarer are complications that occur within the abdomen. We report a case of migrating epicardial pacing wires entering the abdomen and penetrating the transverse colon found incidentally on colonoscopy in an asymptomatic patient.

Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus.

INTRODUCTION: Aspirin (ASA) irreversibly inhibits platelet cyclooxygenase-1 (COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on platelet activation, thromboxane generation, oxidative stress and anti-oxidant biomarkers was studied in type 2 diabetes mellitus (DM). MATERIAL AND METHODS: Baseline and post-ASA samples (100/325 mg x 7 days) were obtained from 75 DM patients and 86 healthy controls for urinary 11-dehydro-thromboxane B2 (11 dhTxB2), 8-iso-prostaglandin-F2α (8-isoPGF2α) and serum sP-Selectin, nitrite (NO(2)(-)), nitrate (NO(3)(-)) and paraoxonase 1 (PON1) activity. RESULTS: Compared to baseline controls, baseline DM had higher mean levels of 11 dhTxB2 (3,665 ± 2,465 vs 2,450 ± 1,572 pg/mg creatinine, p=0.002), 8-isoPGF2α (1,457 ± 543 vs 1,009 ± 412 pg/mg creatinine, p<0.0001), NO(2)(-) (11.8 ± 7.3 vs 4.8 ± 5.3 µM, p<0.0001), NO(3)(-) (50.4 ± 39.3 vs 20.9 ± 16.7 µM, p<0.0001) and sP-Selectin (120.8 ± 56.7 vs 93.0 ± 26.1 ng/mL, p=0.02), and the same held for post-ASA levels (p<0.0001). ASA demonstrated no effect on 8-isoPGF2α, NO(2)(-), NO(3)(-), sP-Selectin or PON1 activity in either DM or controls. Post ASA inhibition of urinary 11 dhTxB2 was 71.5% in DM and 75.1% in controls. There were twice as many ASA poor responders in DM than in controls (14.8% and 8.4%) based on systemic thromboxane reduction. Urinary 8-isoPGF2α excretion was greater in DM ASA poor responders than good responders (p<0.009). CONCLUSIONS: This suggests that oxidative stress may maintain platelet function irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources.

Aplicación de hoja de registro de enfermeria en la atención a pacientes con diagnóstico de intoxicación por órganofosforados en la unidad de urgencias del Hospital de Clínicas primer semestre 2005 / Program for tertiary prevention through the physical exercise for older-adults applied in the Unit of Physiotherapy of the Found of Health of Regional Private Banking La Paz

Los oranofosforados son compuestos químicos empleados principalmente para eliminar plagas (insectos, roedores, etc. ). Estas substancias se acompañan de diferente grado de toxicidad afectando al hombre asi como a los animales, deben usarse cuidadosamente adoptanto las debidas precauciones para poder limitar el número y la gravedad de las intoxicaciones, que aumentan a medida que los productos son más numerosos. En la actualidad y en nuestro medio, la venta es llibre e indiscriminada, sin tomar en cuenta los riesgos que ocasionan su mal manejo y utilización, que debido a su alta toxicidad cada día aumenta el numero de víctimas fatales...