[Effects of metabolic triad (25% polarizing solution, mildronat, preductal MR) in acute myocardial infarction].

The aim of the work was to study the effect of metabolic triad with different mechanisms of acting--high-dose Glucose-Insulin-Potassium--25% polarizing solution (25% glucose, 50 IU soluble insulin and 4% 144 ml KCL-GIK), mildronat, preductal MR on the functional condition of heart during the acute myocardial infarction. 20 patients from the main group and 20 from the control one have been under the study. Patients with diabetes and heavy forms of heart failure (killip class>2) were not included in the study. Evaluation of the functional condition of heart was based on ECG and echocardiography data received before and after the treatment. It was determined that the frequency of the rhythm disorder decreases in the conditions of metabolic triad as well as during the thrombolitic reperfusion. Average period of time for normalization of S-T segment elevation made up 5.4+/-1.8 days and 7.3+/-1.2 days in case of the control group. The received data make it relevant to include the complex metabolic triad for preventive purpose during the complications followed after the acute myocardial infarction.

[Effect of a combination of teveten and prestarium in patients with chronic heart failure].

The safety and efficiency of the therapy with the angiotenzin-II receptor blocker--teveten were compared with the ACE inhibitor prestarium and their combination in patients with NYHA functional classes II-III of the chronic heart failure (CHF), who were on conventional therapy with diuretics and cardiac glycosides. The special attention was given to the influence of a combination of teveten and prestarium on morphofunctional performance of the myocardium and vessels, the neurohumoral status, quality of life and survival in patients with left ventricular dysfunction. Our study confirmed that Prestarium or Teveten monotheraphy gives approximately identical result, while their combination have better influence on the quality of life and hemodynamic parameters. The combined use of teveten and the ACE inhibitor prestarium is the most optimal treatment regimen in patients with moderate and severe CHF.

[Dynamics of blood antioxidative activity in relation to ECG changes and the course of acute myocardial infarct]. / Dinamika antiokislitel'noi aktivnosti krovi v zavisimosti ot izmeneniia EKG i kharaktera techeniia ostrogo infarkta miokarda.

Blood serum antioxidation activity (AOA) was studied by the biophysical method of inhibited electrochemiluminescence in 500 patients with acute myocardial infarction. The degree of increased AOA depends on the size of the affected area. AOA intensity is greater in macrofocal than in microfocal myocardial infarction. It was established that in non-complicated myocardial infarction AOA is characterized by smooth dynamics with normalization of the values on the 3d week. Rapid AOA dynamics are encountered in II or III degree chronic congestive circulatory insufficiency. Protracted dynamics of antioxidation activity (longer than 3 weeks) is evidence of a recurrent character of the disease.