Simulating Large-scale Models of Brain Neuronal Circuits using Google Cloud Platform.

Biophysically detailed modeling provides an unmatched method to integrate data from many disparate experimental studies, and manipulate and explore with high precision the resultin brain circuit simulation. We developed a detailed model of the brain motor cortex circuits, simulating over 10,000 biophysically detailed neurons and 30 million synaptic connections. Optimization and evaluation of the cortical model parameters and responses was achieved via parameter exploration using grid search parameter sweeps and evolutionary algorithms. This involves running tens of thousands of simulations requiring significant computational resources. This paper describes our experience in setting up and using Google Compute Platform (GCP) with Slurm to run these large-scale simulations. We describe the best practices and solutions to the issues that arose during the process, and present preliminary results from running simulations on GCP.

Using Google Street View to examine associations between built environment characteristics and U.S. health outcomes.

Neighborhood attributes have been shown to influence health, but advances in neighborhood research has been constrained by the lack of neighborhood data for many geographical areas and few neighborhood studies examine features of nonmetropolitan locations. We leveraged a massive source of Google Street View (GSV) images and computer vision to automatically characterize national neighborhood built environments. Using road network data and Google Street View API, from December 15, 2017-May 14, 2018 we retrieved over 16 million GSV images of street intersections across the United States. Computer vision was applied to label each image. We implemented regression models to estimate associations between built environments and county health outcomes, controlling for county-level demographics, economics, and population density. At the county level, greater presence of highways was related to lower chronic diseases and premature mortality. Areas characterized by street view images as 'rural' (having limited infrastructure) had higher obesity, diabetes, fair/poor self-rated health, premature mortality, physical distress, physical inactivity and teen birth rates but lower rates of excessive drinking. Analyses at the census tract level for 500 cities revealed similar adverse associations as was seen at the county level for neighborhood indicators of less urban development. Possible mechanisms include the greater abundance of services and facilities found in more developed areas with roads, enabling access to places and resources for promoting health. GSV images represents an underutilized resource for building national data on neighborhoods and examining the influence of built environments on community health outcomes across the United States.