ABSTRACT
PURPOSE: After a full-thickness total wall excision of a rectal tumor, suturing the defect is generally recommended. Recently, due to various contradictory studies, there is a trend to leave the defects open. Therefore, this study aimed to determine whether leaving the defect open is an adequate management strategy compared with suturing it closed based on postoperative outcomes and recurrences. METHODS: A retrospective review of our prospectively maintained database was conducted. Adult patients who underwent transanal surgery for rectal neoplasm in our institution from 1997 to 2019 were analyzed. Patients were divided into two groups: sutured (group A) or unsutured (group B) rectal defect. The primary outcomes were morbidity (early and late) and recurrence. RESULTS: In total, 404 (239 men) patients were analyzed, 143 (35.4%) from group A and 261 (64.6%) from group B. No differences were observed in tumor size, distance from the anal verge or operation time. The overall incidence of complications was significantly higher in patients from group B, which nearly double the rate of group A. With a mean follow-up of 58 (range, 12-96) months, seven patients presented with a rectal stricture, all of them from group B. CONCLUSIONS: We acknowledge the occasional impossibility of closing the defect in patients who undergo local excision; however, when it is possible, the present data suggest that there may be advantages to suturing the defect closed.
Subject(s)
Digestive System Surgical Procedures , Rectal Neoplasms , Male , Adult , Humans , Rectal Neoplasms/surgery , Rectal Neoplasms/pathology , Rectum/surgery , Anal Canal/surgery , Retrospective Studies , Neoplasm Recurrence, Local/pathology , Treatment Outcome , Postoperative Complications/epidemiology , Postoperative Complications/pathologyABSTRACT
BACKGROUND: The outcomes of bariatric surgery should not be evaluated only for weight loss purposes but from a wider point of view that is closer to the reality of morbidly obese patients. The study of the influence of bariatric surgery over obesity-related diseases in bariatric patients is worthwhile. METHODS: We present a cohort study of 329 patients who underwent either laparoscopic sleeve gastrectomy (LSG: 165 patients) or laparoscopic gastric bypass (LRYGBP: 164). We analyzed complication rate, comorbidities and weight loss evolution. RESULTS: Both groups were comparable in demographic characteristics at baseline. Significant statistical differences were found in length of hospital stay and operative time (both were lower in the LSG group). Bleeding and wound infection were higher in the LRYGBP group, as it happened with intestinal occlusion as a late complication (p < 0.05). After a 5-year follow-up, the percentage of excess weight loss (%EWL) was higher in gastric bypass than sleeve gastrectomy (p = 0.01) but there was no statistical difference in percentage of total weight loss (%TWL) (p = 0.2). The resolution of comorbidities was similar in both groups except for dyslipidemia, which resolution was significantly higher in the gastric bypass group (p = 0.005). Metabolic syndrome (MeTS) resolution was similar in both groups. CONCLUSIONS: Sleeve gastrectomy and gastric bypass achieve similar outcomes in hypertension, type 2 diabetes, obstructive sleep apnea and MeTS resolution even when there is weight regain. Although gastric bypass achieves higher weight loss in morbid obese patients, complication rates are also higher compared to those of sleeve gastrectomy. Thus, the appropriate procedure should be tailored based on patient factors and comorbidities, but also on surgeon comfort level and experience.
Subject(s)
Gastrectomy , Gastric Bypass , Metabolism , Adult , Cohort Studies , Comorbidity , Female , Gastrectomy/adverse effects , Gastric Bypass/adverse effects , Humans , Hypertension/complications , Male , Metabolic Syndrome/complications , Obesity, Morbid/surgery , Postoperative Complications/etiology , Treatment Outcome , Weight LossABSTRACT
Asthma is one of the most prevalent chronic diseases in Spain. Current treatments ensure that the disease is controlled in most cases. However, disease is often uncontrolled in daily clinical practice, mainly owing to underdiagnosis, loss to follow-up, and poor adherence to therapy. In order to improve this situation, we must coordinate all those health professionals who intervene in patient care. Therefore, the Spanish Society of Allergology and Clinical Immunology (SEAIC), the Spanish Society of Primary Care Physicians (SEMERGEN), the Spanish Society of Family and Community Medicine (semFYC), the Spanish Society of General and Family Physicians (SEMG), and the Spanish Society of Pneumology and Thoracic Surgery (SEPAR) have drawn up a consensus document in which they establish criteria for referral and guidelines for the diagnosis, control, and follow-up of patients with asthma. The document aims to facilitate continuing and improved care in this area.
Subject(s)
Asthma , Referral and Consultation , Asthma/diagnosis , Asthma/therapy , Consensus , Humans , Primary Health CareABSTRACT
INTRODUCTION: An important fact when facing new technologies is their cost for the Health Publishes. The purpose of this paper is to compare the costs of performing TEM with harmonic scalpel and classic monopolar scalpel and to analyze complications. METHODS: Operation time, blood loss, and hospital stay were recorded to determine the cost of the TEM procedure. We also recorded early and late complications. Patients were divided in two groups: harmonic scalpel group (UC) and monopolar scalpel group (MS). RESULTS: TEM for curative intention was used in 330 rectal tumors from January 1997 to January 2010. A total of 229 patients met the criteria for this study: UC group (n = 87) and MS group (n = 142). Patients from the UC group developed fewer complications (16%) than patients from the MS group (23%). The difference of mean stay between groups was 1.5 days (95% confidence interval, 0.7; 2.2 days; P < 0.001) in favor of the UC group. CONCLUSIONS: Harmonic scalpel provides a safer, easier, and more precise surgical section through clean, bloodless, and better visualized operative field. The additional cost of UC was compensated with the decrease in the health resources (mainly hospital stay).
Subject(s)
Adenocarcinoma/surgery , Microsurgery/instrumentation , Rectal Neoplasms/surgery , Surgical Instruments , Ultrasonic Therapy/instrumentation , Adult , Aged , Aged, 80 and over , Blood Loss, Surgical/statistics & numerical data , Chi-Square Distribution , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Postoperative Complications , Time Factors , Treatment OutcomeABSTRACT
BACKGROUND: Many techniques have excellent results at 2 years of follow-up but some matters regarding their long-term efficacy have arisen. This is why bariatric surgery results must be analyzed in long-term follow-up. The aim of this study was to extend the analysis over 5 years, evaluating weight loss, morbidity, and mortality of the surgical procedures performed. METHODS: This was a retrospective cohort study of the different procedures for morbid obesity practiced in our Department of Surgery for morbid obesity. The results have been analyzed in terms of weight loss, morbidity improvement, and postoperative morbidity (Bariatric Analysis And Reporting Outcome System). RESULTS: One hundred twenty-five patients were operated on open vertical banded gastroplasty (VBG), 150 patients of open biliopancreatic diversion (BPD) of Scopinaro, 100 patients of open modified BPD (common limb 75 cm; alimentary limb 225 cm), and 115 patients of laparoscopic Roux-en-Y gastric bypass (LRYGBP). Mean follow-up was: VBG 12 years, BPD 7 years, and LRYGBP 4 years. An excellent initial weight loss was observed at the end of the second year of follow-up in all techniques, but from this time an important regain of weight was observed in VBG group and a discrete weight regain in LRYGBP group. Only BPD groups kept excellent weight results so far in time. Mortality was: VBG 1.6%, BPD 1.2%, and LRYGBP 0%. Early postoperative complications were: VBG 25%, BPD 20.4%, and LRYGBP 20%. Late postoperative morbidity was: protein malnutrition 11% in Scopinaro BPD, 3% in Modified BPD group, and no cases reported either in VBG group or LRYGBP group; iron deficiency 20% VBG, 62% Scopinaro BPD, 40% modified BPD, and 30.5% LRYGBP. A 14.5% of VBG group required revision surgery to gastric bypass or to BPD due to 100% weight regain or vomiting. A 3.2% of Scopinaro BPD with severe protein malnutrition required revision surgery to lengthen common limb to 100 cm. A 0.8% of LRYGBP required revision surgery to distal LRYGBP (common limb 75 cm) due to 100% weight regain. CONCLUSIONS: The most complex bariatric procedures increase the effectiveness but unfortunately they also increase morbidity and mortality. LRYGBP is safe and effective for the treatment of morbid obesity. Modified BPD (75-225 cm) can be considered for the treatment of superobesity (body mass index > 50 kg/m(2)), and restrictive procedures such as VBG should only be performed in well-selected patients due to high rates of failure in long-term follow-up.
Subject(s)
Biliopancreatic Diversion , Gastroplasty , Weight Loss , Adolescent , Adult , Biliopancreatic Diversion/methods , Body Mass Index , Comorbidity , Female , Humans , Male , Middle Aged , Obesity, Morbid/epidemiology , Obesity, Morbid/surgery , Reoperation , Retrospective Studies , Treatment Outcome , Young AdultABSTRACT
INTRODUCCIÓN: Coincidiendo con el auge de la cirugía endoscópica en todo el mundo se observa una tendencia desigual en la realización de dicha cirugía en el seno de unidades de cirugía sin ingreso. MATERIAL Y MÉTODO: Se realiza un estudio estadístico descriptivo de 511 pacientes operados en una cirugía mayor ambulatoria multidisciplinaria mediante técnicas de cirugía endoscópica. Programa estadístico Stat View 5.0.1 para Windows. RESULTADOS: Los 511 pacientes se distribuyeron entre las especialidades de Urología, 48,%%, Cirugía Ortopédica, 46,4%, Cirugía General, 4,1% y Ginecología, 1%. El 72% fueron varones y la edad media fue de 52 años. Las técnicas endoscópicas suponen un 4,9% de toda la cirugía realizada en la unidad habiéndose producido oscilaciones que fueron del 2,5% al 9,8%. Las artroscopias de rodilla y las exéresis de tumores vesicales superficiales fueron las técnicas más utilizadas. El porcentaje de ingresos no deseados fue del 2,3% y el de complicaciones, siempre menores, del 14,9%. CONCLUSIONES: En nuestra unidad el porcentaje de cirugía endoscópica es bajo y estable en los últimos años. Las características de la lista de espera, la falta de impulso en la promoción de la cirugía ambulatoria y tal vez la falta de entusiasmo en los profesionales, son las causas que determinan la situación actual (AU)
BACKGROUND: As endoscopic surgery increases worldwide its development is controversial in ambulatory surgical units. MATERIAL AND METHODS: A descriptive study was carried out including 511 patients operated on with endoscopic procedures in a multidisciplinary ambulatory surgical unit. Statistical analysis was performed using the Stat View 5.0.1 program. RESULTS: Patients belonged to different surgical specialities, Urology 48.5 per cent, Orthopaedic Surgery 46.4 per cent, General Surgery 4.1 per cent and Gynaecology 1 per cent. A 32 per cent of patients were male and the mean age was 52 years. Endoscopic surgical procedures were 4.9 per cent of the total number of procedures performed in the unit, varying from 2.5 per cent to 9.8 per cent over the period of time studied. Knee arthroscopies and bladder superficial tumour excisions were the most frequent procedures. A 2.3 per cent of unexpected hospital admissions were registered and 14.9 per cent of patients suffered minor complications. CONCLUSION: The study shows a low and stable percentage of endoscopic ambulatory surgery. The characteristics of the waiting list, the low promotion of ambulatory surgery and the lack of enthusiasm between surgeons are the causes of the present situation (AU)
Subject(s)
Male , Female , Middle Aged , Humans , Endoscopy/methods , Ambulatory Surgical Procedures/methods , Ambulatory Surgical Procedures/standards , Minimally Invasive Surgical Procedures/methods , Ambulatory Care/methods , Endosonography/methods , Arthroscopy/methodsSubject(s)
Intestinal Polyps/diagnosis , Rectal Neoplasms/diagnosis , Sigmoid Neoplasms/diagnosis , Adult , Female , Humans , SyndromeABSTRACT
No disponible
Subject(s)
Female , Adult , Humans , Intestinal Polyposis/pathology , Colitis, Ulcerative/pathology , Colonoscopy , Diagnosis, DifferentialABSTRACT
OBJECTIVE: The endoanal sonography in female patients with faecal incontinence is sometimes difficult and can lead to diagnostic errors. The aim of this study is to evaluate the value of endovaginal sonography in such cases. MATERIAL AND METHOD: Thirty female patients complaining of faecal incontinence are included in the study. Anal endosonography was performed in all of them in a single ambulatory session, pictures were taken from all along the anal and results were analyzed afterward. Vaginal endosonography was then performed using the same equipment. Result from both techniques were compared. RESULTS: Endoanal sonography was performed in all 30 patients. In 17 cases no anomalies were found. In 3 patients a simple internal anal sphincter defect was found. One case showed a lateral lesion in both sphincters. Six cases presented anterior external defect and in the rest 3 cases a clear view of the anterior wall was impossible. Vaginal endosonography shows a clear image of the anal canal in 23 out of 30 patients. In two cases changed the results of anal endosonography. CONCLUSION: In the study of faecal incontinence, despite of its technical limitations, endovaginal ultrasound could be of help when the anterior wall of the anal canal is not properly defined.
Subject(s)
Fecal Incontinence/diagnostic imaging , Adult , Aged , Female , Humans , Middle Aged , Ultrasonography/methods , VaginaABSTRACT
Objetivo: el estudio ecográfico endoanal en la mujer con incontinencia fecal presenta en ocasiones dificultades que pueden llevar a errores de diagnóstico sobre todo cuando se valoran las imágenes de la cara anterior. En este trabajo nos hemos propuesto estudiar la eficacia de la ecografía endovaginal en estos casos. Material y método: treinta mujeres afectas de incontinencia fecal se incluyen en el estudio. Todas fueron exploradas en régimen ambulatorio mediante ecografía endoanal, tomando imágenes secuenciales del canal anal y analizando los resultados. Posteriormente, se realizó ecografía endovaginal con el mismo equipo y en la misma sesión. Se compararon los resultados de ambas técnicas. Resultados: en las 30 pacientes se pudo realizar la ecografía endoanal, en 17 enfermas no se hallaron anomalías. En 3 pacientes se apreció defecto único de esfínter anal interno. Una paciente presentaba defecto de ambos esfínteres latero-posterior. En 6 ocasiones se apreció defecto anterior de esfínter anal medio-alto. En otros 3 casos no se logró una buena visión del canal anal anterior. Con la ecografía endovaginal se apreció claramente el canal anal en 23 casos y no se consiguieron imágenes adecuadas en 7 y cambió el criterio de la ecografía endoanal en 2 ocasiones. Conclusión: en el estudio de la incontinencia fecal, la ecografía endovaginal a pesar de presentar limitaciones técnicas puede ser útil en los casos en los que se plantean dudas sobre la integridad de la pared anterior del conducto anal
Objective: the endoanal sonography in female patients with faecal incontinence is sometimes difficult and can lead to diagnostic errors. The aim of this study is to evaluate the value of endovaginal sonography in such cases. Material and method: thirty female patients complaining of faecal incontinence are included in the study. Anal endosonography was performed in all of them in a single ambulatory session, pictures were taken from all along the anal and results were analyzed afterward. Vaginal endosonography was then perfomed using the same equipment. Result from both techniques were compared. Results: endoanal sonography was performed in all 30 patients. In 17 cases no anomalies were found. In 3 patients a simple internal anal sphincter defect was found. One case showed a lateral lesion in both sphincters. Six cases presented anterior external defect and in the rest 3 cases a clear view of the anterior wall was imposible. Vaginal endosonography shows a clear image of the anal canal in 23 out of 30 patients. In two cases changed the results of anal endosonography. Conclusion: in the study of faecal incontinence, despite of its technical limitations, endovaginal ulltrasound could be of help when the anterior wall of the anal canal is not properly defined
Subject(s)
Female , Adult , Aged , Middle Aged , Humans , Fecal Incontinence , Anal Canal/abnormalities , Hemorrhoids/complications , Rectal Prolapse/complications , Rectal Fistula/complications , Anal CanalABSTRACT
OBJECTIVE: The aim of this study is to clinically test the efficacy of a new approach for patients having symptomatic grade III and IV hemorrhoids. MATERIAL AND METHOD: 32 patients (17 females) complaining of grade III or IV hemorrhoids were included in the study. A specially designed proctoscope coupled with a Doppler transducer on its tip was used to identify the hemorrhoidal arteries, which were afterwards suture ligated. Operating time as well as per- and post-operative complications were analyzed. Follow-up was planned following discharge after 1 week, 1 month, 6 months and 1 year. RESULTS: Mean operation time was 27 (range 18-43) minutes, and 5 (range 4-7) arteries were located on average. No patient had severe or moderate postoperative pain, with anal discomfort being the main complaint. Rectal bleeding and tenesmus were the commonest post-operative complications. After one year of follow-up, 19 patients were free of symptoms and 6 of them had significant symptom relief. According to grade, the technique failed in just 3 grade III patients, but in as many as 4 grade IV hemorrhoid cases. CONCLUSIONS: Doppler-guided hemorrhoid artery ligation is an easy-to-perform technique that is well accepted by patients and has good results for grade III hemorrhoids.
Subject(s)
Hemorrhoids/diagnostic imaging , Hemorrhoids/surgery , Ultrasonography, Doppler , Adult , Aged , Female , Humans , Ligation/methods , Male , Middle Aged , Time FactorsABSTRACT
Objetivo: el objetivo de este trabajo es valorar en la clínica laeficacia de una nueva técnica quirúrgica para el tratamiento de lashemorroides de grado III y IV.Material y método: se incluyen en el estudio 32 pacientes(17 mujeres), 27 presentaban hemorroides de grado III y 5 de gradoIV. Para la técnica se utilizó un prostoscopio transparente queincorpora un transductor Doppler en su extremo para localizar lasarterias hemorroidales que se ligan mediante puntos que englobanla mucosa y submucosa. Se analizó el tiempo de intervención y lascomplicaciones intra y postoperatorias, así como las recidivas.Los pacientes fueron controlados al alta, a la semana, mes, 6 mesesy al año de la intervención.Resultados: el tiempo medio de intervención fue de 27 (rango18-43) minutos, localizando de media 5 (rango 4-7) ramas arteriales.No existieron complicaciones intraoperatorias. Ningún paciente presentó dolor severo o moderado en alguno de los controles,refiriendo habitualmente molestias anales discretas. La rectorragiaautolimitada y el tenesmo fueron las complicaciones postoperatoriasmás frecuentes. Tras el seguimiento a 1 año, 19enfermos estaban asintomáticos y en 6 ocasiones los síntomas habíandisminuido significativamente, en el resto la intervención fueineficaz. Agrupados los pacientes por grados, la técnica presentómalos resultados en sólo 3 pacientes con hemorroides grado III,pero en hemorroides grado IV, los resultados fueron malos en 4de los 5 pacientes.Conclusiones: la ligadura de la arteria hemorroidal guiadapor Doppler es una técnica sencilla, bien tolerada, con buenos resultadosen hemorroides grado III
Objective: the aim of this study is to clinically test the efficacyof a new approach for patients having symptomatic grade III andIV hemorrhoids.Material and method: 32 patients (17 females) complainingof grade III or IV hemorrhoids were included in the study. A speciallydesigned proctoscope coupled with a Doppler transducer onits tip was used to identify the hemorrhoidal arteries, which wereafterwards suture ligated. Operating time as well as per- and postoperativecomplications were anlyzed. Follow-up was planned followingdischarge after 1 week, 1 month, 6 months and 1 year.Results: mean operation time was 27 (range 18-43) minutes,and 5 (range 4-7) arteries were located on average. No patienthad severe or moderate postoperative pain, with anal discomfortbeing the main complaint. Rectal bleeding and tenesmus were thecommonest post-operative complications. After one year of follow-up, 19 patients were free of symptoms and 6 of them had significantsymptom relief. According to grade, the technique failedin just 3 grade III patients, but in as many as 4 grade IV hemorrhoidcases.Conclusions: doppler-guided hemorrhoid artery ligation is aneasy-to-perform technique that is well accepted by patients andhas good results for grade III hemorrhoids
Subject(s)
Female , Adult , Humans , Hemorrhoids/complications , Hemorrhoids/etiology , Hemorrhoids/surgery , Ligation/methods , Ligation , Risk Factors , Ultrasonography/methods , UltrasonographyABSTRACT
Chronic sclerosing mediastinitis (CSM) is a rare disease whose etiology varies and which usually develops through mediastinal compression syndromes, generally due to occlusion of the superior vena cava. We report a case of CSM diagnosed after a chance finding of unilateral diaphragm paralysis, a circumstance not previously reported in the literature. We review the clinical, radiological and histological features of CSM.
Subject(s)
Mediastinitis/complications , Respiratory Paralysis/etiology , Chronic Disease , Female , Humans , Middle AgedABSTRACT
Primary ciliary dyskinesia (PCD) is a genetic disorder characterized by the inability of ciliated structures to beat effectively. Clinical course includes recurrent sinus and ear infections, chronic or recurrent bronchitis and infertility in men. Although several phenotypes have been described, lung function deterioration secondary to bronchiectasis becomes severe only rarely. That upper airway tract infections go unnoticed has not been reported. We report a case of PCD characterized by immotile sperm, severe obstructive respiratory disorder that required a sequential double lung transplant with the absence of recurrent sinus and ear infections.
Subject(s)
Ciliary Motility Disorders/genetics , Adult , Humans , Male , PhenotypeABSTRACT
La discinesia ciliar primaria (DCP) es un trastorno genético caracterizado por una incapacidad del batido ciliar, que cursa clínicamente con sinusitis y otitis de repetición, bronquitis crónica o recurrente e infertilidad en el varón. Aunque se han descrito diversas variantes fenotípicas, no es frecuente que el deterioro de la función pulmonar, secundario a la presencia de bronquiectasias, llegue a ser muy grave. Tampoco es conocido que las infecciones de las vías respiratorias altas pasen desapercibidas. Presentamos un caso de DCP caracterizado por inmotilidad espermática, grave trastorno ventilatorio obstructivo, que requirió un trasplante bipulmonar secuencial, y ausencia objetiva de sinusitis u otitis recurrentes (AU)
Subject(s)
Adult , Male , Humans , Phenotype , Ciliary Motility DisordersABSTRACT
OBJECTIVES: To determine the epidemiology of community-acquired pneumonia referred to the hospital and to characterize the diagnostic and therapeutic approach adopted by physicians. METHOD: Retrospective epidemiological and descriptive clinical study based on case histories consistent with a diagnosis of community-acquired pneumonia (Fang et al. Medicine, 1990; 69:307-16) of patients referred to hospitals in Soria (Spain) over a period of one year. The patients were grouped by severity and the presence of risk factors for unusual etiology. Initial approaches were compared to those advocated by various sources. RESULTS: Three hundred eight cases of community-acquired pneumonia were diagnosed, and 82% of the patients were admitted. Mean age was 68 +/- 26 years (43% over 80 years of age). Men accounted for 56%. Two hundred seventeen patients (70%) were classified as seriously ill, 203 (66%) had risk factors for unusual etiology, and 166 (54%) were classified in both categories. Mortality among admitted patients was 13%. Etiological diagnoses did not correspond to the guidelines of the Spanish Society of Pneumology and Chest Surgery (SEPAR), with microbial identification achieved in 5%. Empirical treatment followed SEPAR guidelines in 45% of the cases. The Mensa guidelines were followed in 23% and the Sanford guidelines in 20%. CONCLUSIONS: The incidence of community-acquired pneumonia in this population is 3.2 cases per 1,000 inhabitants/year. The population is mainly elderly and comorbidity is common, although mortality is low. We believe common criteria should be adopted for managing community-acquired pneumonia and that empirical treatment should be directed toward germs identified in each setting, based on appropriate etiological investigation.
Subject(s)
Hospitalization , Pneumonia/epidemiology , Referral and Consultation , Adolescent , Adult , Aged , Aged, 80 and over , Chi-Square Distribution , Child , Community-Acquired Infections/diagnosis , Community-Acquired Infections/epidemiology , Community-Acquired Infections/therapy , Female , Hospitalization/statistics & numerical data , Humans , Incidence , Male , Middle Aged , Pneumonia/diagnosis , Pneumonia/therapy , Referral and Consultation/statistics & numerical data , Retrospective Studies , Risk Factors , Spain/epidemiologyABSTRACT
OBJECTIVE: Make a epidemiological and descriptive analysis of the tuberculosis patients care, researching problems which may be the etiology of the increase of illness. DESIGN: Descriptive observing retrospective study. SETTING: Soria County. PATIENTS: 186 cases with positive Mycobacterium tuberculosis culture, since January 1, 1983 until December 31, 1993. RESULTS: The 65.4% of patients were hospitalized to make the diagnostic and/or to begin treatment. We found delayed diagnostics much as 5.5 years. The mean was 120.9 +/- 244.7 days until the diagnostic was performed, 1991 y 1992 were the highest delayed time to diagnostic years of the study. The diagnostic and control of the 99.5% of patients was done at hospital. Only a 64% of patients could be considered as healthy at the onset of his control. CONCLUSIONS: Most of physicians consider the tuberculosis as a hospital illness, so there are delayed diagnostic and therapeutics and worse control of evolution, therapy compliance and contacts study.
Subject(s)
Medical Audit/statistics & numerical data , Primary Health Care/statistics & numerical data , Tuberculosis, Pulmonary/diagnosis , Antitubercular Agents/therapeutic use , Chi-Square Distribution , Confidence Intervals , Drug Therapy, Combination , Follow-Up Studies , Hospitalization , Humans , Retrospective Studies , Spain , Statistics, Nonparametric , Time Factors , Treatment Outcome , Tuberculosis, Pulmonary/drug therapyABSTRACT
The diagnostic criteria, incidence, clinical characteristics and outcome of 397 patients with monoclonal gammopathies of undetermined significance, all of them diagnosed and followed-up at the Haematology Service of the Miguel Servet Hospital, in Zaragoza, between January 1970 and December 1988, were revised. The patients' mean age was 64.7 years (range: 2-89). The M/F ratio was 236/161. The mean concentration of the M component (MC) was 1.17 g/dL (range: 0.20-3.50), this being under 0.50 in 65 cases. IgG was the most frequent MC (71.26%), followed by IgA (14.34%) and IgM (10.82%). Multiple MC was present in 14 cases (3.58). Light chains were passed in urine by 33 patients (8.31%). No associated pathology was found in 213 patients (53.65%) upon MC discovery, while 65 other (16.31%) were carriers of different blood disorders, chronic lymphoproliferative diseases being the commonest (11.57%). In 30 patients (7.30%) the MC was associated to nonhaematological malignancies, and 29 others had an underlying chronic infection. Chronic liver disease was present in 25 cases, and autoimmune disease in 14. Transient monoclonal gammopathy was seen in a small group of patients (6.54%), most of them suffering from acute infectious illness. With regard to the group of patients without any associated pathology, their median follow-up was 37.8 months (range: 18-228). Of them, the MC kept unchanged in 134 cases (62.91%); 47(22.06%) died from any unrelated cause, and 10 others evolved into malignant monoclonal gammopathy. The median clinical course of these last expanded to 60 months (range: 11-124), with an accumulated actuarial risk of 4.5% at 5 years, 15% at 10 years and 26% at 15 years.
Subject(s)
Paraproteinemias , Actuarial Analysis , Adolescent , Adult , Aged , Aged, 80 and over , Autoimmune Diseases/complications , Child , Child, Preschool , Female , Humans , Infections/complications , Liver Diseases/complications , Lymphoproliferative Disorders/complications , Male , Middle Aged , Multiple Myeloma/epidemiology , Neoplasms/complications , Paraproteinemias/epidemiology , Paraproteinemias/etiology , Paraproteinemias/metabolism , Paraproteinemias/pathology , Paraproteins/analysis , Prevalence , Retrospective Studies , RiskSubject(s)
Anemia, Hypochromic , Iron Deficiencies , Adolescent , Age Factors , Aged , Anemia, Hypochromic/diagnosis , Anemia, Hypochromic/drug therapy , Anemia, Hypochromic/etiology , Animals , Child , Child, Preschool , Female , Ferritins/analysis , Gastrointestinal Hemorrhage/complications , Humans , Infant , Infant, Newborn , Iron/therapeutic use , Malabsorption Syndromes/complications , Male , Menorrhagia/complications , Middle Aged , Nutrition Disorders/complications , Pregnancy , Pregnancy Complications, Hematologic , RatsABSTRACT
The clinical histories and thorax X-rays of 91 patients aged between 15 and 25 years who were admitted at the Hospital Royo Villanova, Zaragoza from 1983 to 1987 because of active pulmonary tuberculosis, were reviewed in order to study the radiological presentation of pulmonary tuberculosis in young patients and examine if there were any differences with other age groups. We highlight from the results: 1) The male/female ratio was 1.5/1.2) There were no differences in the radiological presentation between this group and older subjects, 3) The radiological localization of the lesions was the classical one, 4) The mean clinical evolution time before diagnosis was made, was of three months, 5) A longer evolution time was related to a greater lesion extension. We highlight that a prompt X-ray contributes to the early diagnosis of pulmonary tuberculosis in young patients avoiding delays in diagnosis and treatment.