ABSTRACT
PURPOSE: This pivotal study aimed to evaluate circulating levels of bone remodeling markers in children and adolescents at the onset of type 1 diabetes (T1D). Additionally, we assessed their correlation with glucose control, residual ß-cell function, and the severity of presentation. METHODS: In this single-center cross-sectional study, we recruited children and adolescents newly diagnosed with T1D at our tertiary-care Diabetes Centre. Anamnestic, anthropometric, clinical, and biochemical data at T1D diagnosis were collected. Basal and stimulated C-peptide levels were assessed, along with the following bone remodeling biomarkers: osteocalcin (OC), alkaline phosphatase (ALP), parathormone (PTH), 25-OH Vitamin D (25OH-D), and the C-terminal cross-linked telopeptide of type 1 collagen (CTX). RESULTS: We enrolled 29 individuals newly diagnosed with T1D, with a slight male prevalence (51.7%). The mean age was 8.4 ± 3.7 years. A positive correlation between OC and stimulated C-peptide (R = 0.538; p = 0.026) and between PTH and serum HCO3- (R = 0.544; p = 0.025) was found. No other correlations between bone remodeling biomarkers and clinical variables were detected. CONCLUSION: Our data showed a positive correlation between OC levels and residual ß-cell function in children and adolescents at T1D presentation. Further longitudinal studies evaluating OC levels in pediatric subjects with T1D are needed to better understand the complex interaction between bone and glucose metabolisms.
ABSTRACT
El mesotelioma maligno es un tumor que se presenta en relación 1: 4000 pacientes autopsiados por neoplasias malignas. La localización pericárdica es la menos frecuente, constituyendo menos del 2 por ciento del total de tumores cardíacos. Se presenta un caso en el que el tumor produjo un síndrome de taponamiento cardíaco, sin ser diagnosticado en vida a pesar de efectuarse una biopsia pericárdica subxifoidea. El paciente murió bruscamente, halládose en la autopsia dicho tumor infiltrando la aurícula derecha y haciendo protusión en la cavidad, englobando la arteria coronaria derecha. Esto último podría ser responsable de la muerte. Se comparan los hallazgos clínicos y patológicos con 30 casos extraídos de la literatura reciente (AU)
Subject(s)
Humans , Female , Middle Aged , Mesothelioma/pathology , Pericardium/pathology , Heart Neoplasms/pathology , Lung Neoplasms/secondary , Pleural Neoplasms/pathology , Neoplasm Invasiveness , Fatal OutcomeABSTRACT
Malignant mesothelioma is a tumor which occurs in one out of every 4,000 patients autopsied for malignant neoplasia. Pericardial location is the least frequently encountered, accounting for less than 2
of the total cardiac tumors. We are presenting here a patient in whom the tumor resulted in a syndrome of cardiac tamponade. It could not be diagnosed in the living patient in spite of having performed a subxiphoideal pericardic biopsy. The patient died suddenly, and the tumor was found during autopsy, infiltrating the right atrium and protruding into the cavity, involving the right coronary artery. This latter situation could have been responsible for the patients death. Clinical and pathological findings are compared with those of 30 cases found in recent literature.
ABSTRACT
El mesotelioma maligno es un tumor que se presenta en relación 1: 4000 pacientes autopsiados por neoplasias malignas. La localización pericárdica es la menos frecuente, constituyendo menos del 2 por ciento del total de tumores cardíacos. Se presenta un caso en el que el tumor produjo un síndrome de taponamiento cardíaco, sin ser diagnosticado en vida a pesar de efectuarse una biopsia pericárdica subxifoidea. El paciente murió bruscamente, halládose en la autopsia dicho tumor infiltrando la aurícula derecha y haciendo protusión en la cavidad, englobando la arteria coronaria derecha. Esto último podría ser responsable de la muerte. Se comparan los hallazgos clínicos y patológicos con 30 casos extraídos de la literatura reciente